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Mucosal addressin cell adhesion molecule-1 (MAdCAM-1)

Its binding motif for α4β7 and role in experimental colitis

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Abstract

The integrin α4β7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are molecules involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract. These molecules may play a complementary and significant role in animal models of colitis. We have investigated the structural interaction between α4β7 and MAdCAM-1. Site-directed mutagenesis studies of the MAdCAM-1 molecule has led to the identification of the amino acid residue (LDT) in the loop between β strands C and D of the Ig-superfamily-like folds being involved in the adhesive and cell activation functions of MAdC AM-1 with α4β7.

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Authors and Affiliations

  1. Department of Immunology, Genentech, Inc., 460 Point, 94080-4990, San Francisco, CA

    Sherman Fong, Susan Jones, Mark E. Renz, Henry H. Chiu & Leonard G. Presta

  2. Department of Pathology, Genentech, Inc., South San Francisco, CA

    Anne M. Ryan

  3. Department of Bio-Organic Chemistry, Genentech, Inc., South San Francisco, CA

    David Jackson

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  1. Sherman Fong
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Correspondence to Sherman Fong.

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Fong, S., Jones, S., Renz, M.E. et al. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Immunol Res 16, 299–311 (1997). https://doi.org/10.1007/BF02786396

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