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Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1

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Abstract

An equilibrium between positive and negative regulation of immunoreceptor signaling leads to the proper execution of lymphocyte activation. Tyrosine phosphorylation is the initial event in antigen receptor-induced lymphocyte activation. It is generally accepted that protein tyrosine kinases are involved in positive regulation, whereas protein tyrosine phosphatases are important for the negative regulation of tyrosine phosphorylation-dependent processes. However, the interaction between protein tyroine kinases and protein tyrosine phosphatases is complex. This article discusses the role of two protein tyrosine phosphatases, CD45 and SHP-1, in the regulation of immunoreceptor signaling. SHP-1 acts as a negative regulator for several immunoreceptors, including those for T-and B-cell antigen receptors. The major role of CD45 is in the positive regulation of T- and B-cell antigen receptor signaling.

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Authors and Affiliations

  1. School of Medicine, Washington University, 660 South Euclid Avenue, Box 8118, 63110, St.Louis, MO

    Tatiana Ulyanova, Julie Blasioli & Matthew L. Thomas

  2. Department of Pathology, Howard Hughes Medical Institute, St.Louis, MO

    Tatiana Ulyanova

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  1. Tatiana Ulyanova
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  2. Julie Blasioli
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Ulyanova, T., Blasioli, J. & Thomas, M.L. Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1. Immunol Res 16, 101–113 (1997). https://doi.org/10.1007/BF02786326

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