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Neural regulation of the endocrine pancreas

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References

  1. Bernard C. Chiens rendus diabetiques.Compt Rend Soc Biol 1849; 1: 60.

    Google Scholar 

  2. Langerhans P.Contributions to Microscopic Anatomy of the Pancreas. Morrison H, trans., Johns Hopkins Press, Baltimore, 1937, 39.

    Google Scholar 

  3. Zunz E, LaBarre J. Contribution a l’etude des variations physiologiques de la secretion interne du pancreas.Arch Int Physiol Biochim 1927; 29: 265–280.

    CAS  Google Scholar 

  4. Kaneto A, Kosaka K, Nakas K. Effects of stimulation of the vagus nerve on insulin secretion.Endocrinology 1967; 80: 530–536.

    Article  PubMed  CAS  Google Scholar 

  5. Sergeyeva MA. Microscopic changes in the islands of Langerhans produced by sympathetic and parasympathetic stimulation in the cat.Anat Rec 1940; 77: 297–317.

    Google Scholar 

  6. Wilenko GG. Uber den Einfluss des Adrenalins auf den respiratorischen Quotienten and die Wirkungaswise des Adrenalins.Biochem Z 1912; 42: 44–58.

    CAS  Google Scholar 

  7. Alquist RP. A study of adrenotropic receptors.Am J Physiol 1947; 153; 586–599.

    Google Scholar 

  8. Bloom SR, Edwards AV. Pancreas endocrine responses to stimulation of the peripheral ends of the vagus, nerve in conscious calves.J Physiol 1981; 315: 31–41.

    PubMed  CAS  Google Scholar 

  9. Brunicardi FC, Yamada T, Andersen DK. Splanchnic neural regulation of somatostatin secretion in the isolated perfused human pancreas.Ann Surg 1994; 219: 258–266.

    PubMed  CAS  Google Scholar 

  10. Honey RN, Schwartz JA, Mathe CJ, Weir GC. Insulin, glucagon and somatostatin secretion from isolated, perfused rat and chicken pancreas-duodenum.Am J Physiol 1980; 238: E150–156.

    PubMed  CAS  Google Scholar 

  11. Kirchgessner AL, Gershon MD. Innervation of the pancreas by neurons in the gut.J Neurosci 1990; 10(5): 1626–1642.

    PubMed  CAS  Google Scholar 

  12. Porte D Jr, Graber AL, Kuzuya T, Williams RH. The effect of epinephrine on immunoreactive insulin levels in man.J Clin Invest 1966; 45: 228–236.

    PubMed  CAS  Google Scholar 

  13. Porte D Jr, Williams RH. Inhibition of insulin release by norepinephrine in man.Science 1966; 152: 1248–1250.

    PubMed  CAS  Google Scholar 

  14. Robertson RP, Porte D Jr. Adrenergic modulation of basal insulin secretion in man.Diabetes 1973; 22: 1–8.

    PubMed  CAS  Google Scholar 

  15. Rohner-Jeanrenaud F, Bobbioni E, Ionescu E, Sauter JG, Jeanrenaud B. Central nervous system regulation of insulin secretion, inAdvances in Metabolic Disorders, vol. 10., Szabo AJ, ed., Academic, New York, 1983; pp. 193–257.

    Google Scholar 

  16. Samols E, Weir GC. Adrenergic modulation of pancreatic A, B, and D cells.J Clin Invest 1966; 45: 228–236.

    Google Scholar 

  17. Coupland RE. The innervation of the pancreas of the rat, cat and rabbit as revealed by the cholinesterase technique.J Anat 1958; 92: 143–149.

    PubMed  CAS  Google Scholar 

  18. Miller RE. Pancreatic neuroendocrinology: Peripheral neural mechanisms in the regulation of the islets of Langerhans.Endocrinol Rev 1981; 4: 471–494.

    Google Scholar 

  19. Kaneto A, Sato H, Kaneko T, Yanihara C, Yanihara N, Kosaka K. Stimulation of somatostatin, pancreatic polypeptide, glucagon and insulin secretion by acetylcholine infused intrapancreatically in dogs.Biomed Res 1981; 2: 57–66.

    CAS  Google Scholar 

  20. Van der Zee EA, Buwalda B, Strubbe JH, Strosberg AD, Luiten PG. Immunocytochemical localization of muscarinic acetylcholine receptors in the rat endocrine pancreas.Cell Tissus Res 1992; 269: 99–106.

    Google Scholar 

  21. Stagner JI, Samols E. Modulation of insulin secretion by pancreatic ganglionic nicotinic receptors.Diabetes 1986; 35: 849–854.

    PubMed  CAS  Google Scholar 

  22. Holst JJ, Fahrenkrug J, Knuhtsen S, Jensen SL, Nielsen OV, Lundberg JM, Hokfelt T. VIP and PHI in the pig pancreas: Coexistence, corelease, and cooperative effects.Am J Physiol 1987; 252: G182–189.

    PubMed  CAS  Google Scholar 

  23. Holst JJ, Fahrenkrug J, Knuhtsen S, Jensen SL, Poulsen SS, Nielsen OV. Vasoactive intestinal polypeptide (VIP) in the pig pancreas: Role of VIPergic nerves in the control of fluid and bicarbonate secretion.Regul Pept 1984; 8: 245–259.

    PubMed  CAS  Google Scholar 

  24. Knuhtsen S, Holst JJ, Baldissera FGA, Skak-Nielsen OV. Gastrin-releasing peptide in the porcine pancreas.Gastroenterology 1987; 92: 1153–1158.

    PubMed  CAS  Google Scholar 

  25. Knuhtsen S, Holst JJ, Schwartz TW, Jensen SL, Nielsen OV. The effect of gastrin-releasing peptide on the endocrine pancreas.Regul Pept 1987; 17: 269–276.

    PubMed  CAS  Google Scholar 

  26. Ahren B, Bottcher G, Kowalyk S, Dunning BE, Sundler F, Taborsky GJ Jr. Galanin is co-localized with noradrenaline and neuropeptide Y in dog pancreas and celiac ganglion.Cell Tissue Res 1990; 261: 49–58.

    PubMed  CAS  Google Scholar 

  27. Dunning BE, Havel PJ, Veith RC, Taborsky GJ Jr. Pancreatic and extrapancreatic galanin release during sympathetic neural activation.Am J Physiol 1990; 258: E436–444.

    PubMed  CAS  Google Scholar 

  28. Dunning BE, Ahren B, Veith RC, Taborsky GJ Jr. Nonadrenergic sympathetic neural influences on basal pancreatic hormone secretion.Am J Physiol 1988; 255: E785–792.

    PubMed  CAS  Google Scholar 

  29. Dunning BE, Taborsky GJ Jr. Neural control of islet function by norepinephrine and sympathetic neuropeptides.Adv Exp Med Biol 1991; 291: 107–127.

    PubMed  CAS  Google Scholar 

  30. Malaisse WJ, Malaisse-Lagae JF, Wright PH. Insulin secretion by the pancreas in vitro.Fed Proc 1966; 25: 442.

    Google Scholar 

  31. Malaisse WJ, Malaisse-Lagae JF, Wright PH, Ashmore J. Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.Endocrinology 1967; 80: 975–978.

    PubMed  CAS  Google Scholar 

  32. Woods SC, Porte D Jr. Neural control of the endocrine pancreas.Physiol Rev 1974; 54(3): 596–619.

    PubMed  CAS  Google Scholar 

  33. Bishop AE, Polak JM, Green IC, Bryant MG, Bloom SR. The location of VIP in the pancreas of man and rat.Diabetologia 1980; 18: 73–78.

    PubMed  CAS  Google Scholar 

  34. De Giorgio R, Sternini C, Brecha NC, Widdison AL, Karanjia ND, Reber HA, Go VL Patterns of innervation of vasoactive intestinal polypeptide, neuropeptide Y, and gastrin-releasing peptide immunoreactive nerves in the feline pancreas.Pancreas 1992; 7(3): 376–384.

    Article  PubMed  Google Scholar 

  35. Hakanson R, Sundler F, Uddman R. Distribution and topography of peripheral VIP nerve fibers: Functional implications, inVasoactive Intestinal Peptide, Said SI, ed. Raven, New York, 1982, pp. 121–144.

    Google Scholar 

  36. Larsson LI, Fahrenkrug J, Holst JJ, Schaffalitzky de Muckadell OB. Innervation of the pancreas by vasoactive intestinal polypeptide (VIP) immunoreactive nerves.Life Sci 1978; 22: 773–780.

    PubMed  CAS  Google Scholar 

  37. Larsson LI, Fahrenkrug J, Schaffalitzky de Muckadell OB. Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons.Proc Natl Acad Sci USA 1976; 73: 5197–5200.

    Google Scholar 

  38. Marongiu L, Perra MT, Pinna AD, Sirigu F, Sirigu P. Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: An immunohistochemical study.Histol & Histopath 1993; 8(1): 127–132.

    CAS  Google Scholar 

  39. Sundler F, Alumets J, Hakanson R, Fahrenkrug J, Schaffalitzky de Muckadell O. Peptidergic (VIP) nerves in the pancreas.Histochemistry 1978; 55: 173–176.

    PubMed  CAS  Google Scholar 

  40. Sundler R, Ekblad E, Grunditz T, Hakanson R, Uddman R. Vasoactive intestinal peptide in the peripheral nervous system.Ann NY Acad Sci 1988; 527: 143–167.

    PubMed  CAS  Google Scholar 

  41. Shimosegawa T, Asakura T, Kashimura J, Yoshida K, Meguro T, Koizumi M, Mochizuki T, Yanaihara N, Toyota T. Neurons containing gastrin releasing peptide-like immunoreactivity in the human pancreas.Pancreas 1993; 8(4): 402–412.

    Google Scholar 

  42. Ahren B, Sundler F. Localization of calcitonin, gene-related peptide and islet amyloid polypeptide in the rat and mouse pancreas.Cell Tissue Res 1992 Aug; 269 (2): 315–322.

    PubMed  CAS  Google Scholar 

  43. Mulderry PK, Ghatei MA, Bishop AE, Allen YS, Polak JM, Bloom SR. Distribution and chromatographic characterization of CGRP-like immunoreactivity in the brain and gut of the rat.Regul Pept 1985; 12: 133–143.

    PubMed  CAS  Google Scholar 

  44. Pettersson M, Ahren B, Bottcher G, Sundler F. Calcitonin gene-related peptide: Occurrence in pancreatic islets in the mouse and in the rat and inhibition of insulin secretion in the mouse.Endocrinology 1986; 119: 865–869.

    PubMed  CAS  Google Scholar 

  45. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.Nature 1983; 304: 129–135.

    PubMed  CAS  Google Scholar 

  46. Sternini C, Brecha N. Immunocytochemical identification of islet cells and nerve fibers containing calcitonin generelated peptide immuno-reactivity in the, rat pancreas.Gastroenterology 1986; 90: 1155–1163.

    PubMed  CAS  Google Scholar 

  47. Sternini C, Card JP. Ultrastructural characterization of calcitonin gene-related peptide-containing fibers and islet cells in the rat pancreas.Pancreas 1991; 6(4): 375–384.

    PubMed  CAS  Google Scholar 

  48. Sternini C, De Giorgio R, Anderson K, Watt PC, Brunicardi FC, Widdison AL, Wong H, Reber HA Walsh JH, Go VL. Species differences in the immunoreactive patterns of calcitonin gene-related peptide in the pancreas.Cell Tissue Res 1992 269(3): 447–458.

    PubMed  CAS  Google Scholar 

  49. Su HC, Bishop AE, Power RF, Hamada Y, Polak JM. Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas.J Neurosci 1987; 7: 2674–2687.

    PubMed  CAS  Google Scholar 

  50. Ahren B, AríRajab A, Bottcher G, Sundler F, Dunning BE. Presence of galanin in human pancreatic nerves and inhibition of insulin secretion from isolated human islets.Cell Tissue Res 1991 May; 264 (2): 263–267.

    PubMed  CAS  Google Scholar 

  51. Ekblad E, Wahlestedt C, Ekelund M, et al. Neuropeptide Y in the gut and pancreas: Distribution and possible vasomotor function.Front Horm Res 1984; 12: 85–90.

    Google Scholar 

  52. Epstein S, Berelowitz M. The lack of adrenergic effects of somatostatin-like immunoreactivity in normal man.Neuropeptides 1981; 2: 53–58.

    CAS  Google Scholar 

  53. Gilon P, Tappaz M, Remacle C. Localization of GAD-like immunoreactivity in the pancreas and stomach of the rat and mouse.Histochemistry 1991; 96(4): 355–365.

    PubMed  CAS  Google Scholar 

  54. Dunning BE, Ahren B, Veith RC, Bottcher G, Sundler F, Taborsky GJ. Galanin: a novel pancreatic neuropeptide.Am J Physiol 1986; 251: E127–133.

    PubMed  CAS  Google Scholar 

  55. Havel PJ, Taborsky GJ Jr. The contribution of the autonomic nervous system to changes of glucagon and insulin secretion during hypoglycemic stress.Endocr Rev 1989; 10(3): 332–350.

    PubMed  CAS  Google Scholar 

  56. Lindskog S, Ahren B, Dunning BE, Sundler F. Galanin-immunoreactive nerves in the mouse and rat pancreas.Cell Tiss Res 1991; 264(2): 363–368.

    CAS  Google Scholar 

  57. McDonald TJ, Brooks BD, Rokaeus A, Tinner B, Staines WA. Pancreatic galanin: Molecular forms and anatomical locations.Pancreas 1992; 7(6): 624–635.

    PubMed  CAS  Google Scholar 

  58. Messell T, Harling H, Bottcher G, Johnsen AH, Holst JJ. Galanin in the porcine pancreas.Regul Pept 1990; 28: 161–176.

    PubMed  CAS  Google Scholar 

  59. Larsson LI. New aspects on the neural, paracrine and endocrine regulation of islet function.Front Horm Res 1980; 7: 14–29.

    CAS  Google Scholar 

  60. De Giorgio R, Parodi JE, Brech NC, Brunicardi FC, Becker JM, Go VL, Sternini C. Nitric oxide producing neurons in the monkey and human digestive system.J Comp Neurol 1994; 342(4): 619–627.

    PubMed  Google Scholar 

  61. Ekblad E, Alm P, Sundler F. Distribution, origin and projections of nitric oxide synthase-containing neurons in gut and pancreas.Neuroscience 1994; 63: 233–248.

    PubMed  CAS  Google Scholar 

  62. Liu HP, Leong SK, Tay SS. Localization of NADPH-diaphorase positive neurons in the pancreas of the mouse, rat, chick, kitten and monkey.J fur Hirnforschung 1994; 35(4): 501–510.

    CAS  Google Scholar 

  63. World J, Wiesand M, Mayer B, Greskotter KR, Neuhuber WL. Neuronal and endothelial nitric oxide synthase immunoreactivity and NADPH-diaphorase staining in rat and human pancreas: influence, of fixation.Histochemistry 1994; 102: 353–364.

    Google Scholar 

  64. Jansson L, Sandler S. The nitric oxide synthase II inhibitor NG-nitri-l-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas.Endocrinology 1991; 128: 3081–3085.

    PubMed  CAS  Google Scholar 

  65. Moldovan S, Livingston E, Zhang RS, Kleinman R, Guth P, Brunicardi FC. Glucose induced islet hyperemia is mediated by nitric oxide.Am J Surg (in press).

  66. Kuntz A.The Autonomic Nervous System. Lea and Febiger, Philadelphia, 1953, 605.

    Google Scholar 

  67. Bengtsson M, Lofstrom JB. Nerve block in pancreatic pain.Acta Chirurgica Scandinavica 1990; 156,4: 285–291.

    PubMed  CAS  Google Scholar 

  68. Holzer P, Livingston EH, Guth PH. Sensory neurons signal for an increase in rat gastic mucosal blood flow in the face of pending acid injury.Gastroenterology 1991; 101(2): 416–423.

    PubMed  CAS  Google Scholar 

  69. Watt PC, Livingston EH, DiGiorgio R, Sternini CH, Zinner MJ, Brunicardi FC. Afferent sensory denervation alters first phase insulin secretion in isolated perfused rat pancreas.Dig Dis Sci 1991; 50: 1391.

    Google Scholar 

  70. Anglade P, Michel C, Roze C. Intrinsic nerves of the pancreas after celiac and superior mesenteric ganglionectomy in rats: A morphologic study of acetylcholinesterase activity and catecholamine histofluorescence.Pancreas 1987; 2: 568–577.

    PubMed  CAS  Google Scholar 

  71. Koevary SB, Azmitia EC, McEvoy RC. Rat pancreatic serotonergic nerves: Morphologic, pharmacologic and physiologic studies.Brain Res 1983; 265: 328–332.

    PubMed  CAS  Google Scholar 

  72. Koevary SB, McEvoy RC, Azmitia EC. Specific uptake of tritiated serotonin in the adult rat pancreas: Evidence for the presence of serotonergic fibers.Am J Anat 1980; 159: 361–368.

    PubMed  CAS  Google Scholar 

  73. Nunez EA, Gershon P, Gershon MD. Serotonin and seasonal variation in the pancreatic structure of bats: Possible evidence for serotonin axons in the gland.Am J Anat 1980; 159: 361–368.

    Google Scholar 

  74. Furness JB, Costa M.The Enteric Nervous System. Churchill Livingston, New York, 1982; p. 290.

    Google Scholar 

  75. Gershon MD, Mawe GM, Branchek TA. 5-Hydroxytryptaminergic neurotransmission in the gut, inCardiovascular Pharmacology of 5-hydroxytryptamine: Prospective Therapeutic Applications, Saxena PR, Wallis DI, Wouter W, Vevan P, eds., Kluwer Academic, Netherlands, 1990; pp. 191–210.

    Google Scholar 

  76. Kleinman R, Gingerich R, Wong H, Walsh J, Lloyd K, Ohning G, De Goorgio R, Sternini C, Brunicardi FC. The use of the Fab fragment for immunoneutralization of somatostatin in the isolated perfused pancreas.Am J Surg 1994; 167: 114–119.

    PubMed  CAS  Google Scholar 

  77. Kleinman R, Watt P, Ohning G, Wong H, Walsh J, Brunicardi FC. The regulatory role of intraislet somatostatin on insulin secretion in the isolated perfused human pancreas.Pancreas 1993; 9, 2: 172–178.

    Article  Google Scholar 

  78. Samols E, Stagner JI. Intraislet and islet-acinar portal systems and their significance, inComprehensive Endocrinology: The Endocrine Pancreas, Samols E, ed., Raven, New York, 1991; pp. 93–124.

    Google Scholar 

  79. Greenberg GR, McDonald TJ. Effect of galanin and vagal integrity on insulin release in dogs.Pancreas 1988; 3: 122–127.

    PubMed  CAS  Google Scholar 

  80. Greenberg GR, McDonald TJ, Dupre J. Galanin: nonvagal, non-cholinergic inhibition of canine insulin secretion.Gastroenterology 1986; (Abstr.) 90: 1437.

    Google Scholar 

  81. Holst JJ, Bersani M, Hvidberg A, Knige U, Christiansen E, Madsbad S, Harling H, Kofod H. On the effects of human galanin in man.Diabetologia 1993; 36: 653–657.

    PubMed  CAS  Google Scholar 

  82. Ahren B, Taborsky GJ Jr. The mechanism of vagal nerve stimulation of glucagon and insulin secretion in the dog.Endocrinology 1986; 118: 1551–1557.

    PubMed  CAS  Google Scholar 

  83. Bergman RN, Miller RE. Direct enhancement of insulin secretion by vagal stimulation of the isolated pancreas.Am J Physiol 1973; 225: 481–486.

    PubMed  CAS  Google Scholar 

  84. Brunicardi FC, Sun YS, Druck P, Goulet RJ, Elahi D, Andersen DK. Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreas.Am J Surg 1987; 153: 34–40.

    PubMed  CAS  Google Scholar 

  85. Floyd JC Jr, Fajans SS, Pek S. Physiologic regulation of plasma levels of PP in man, inGut Hormones, Bloom, SR, ed., Churchill Livingstone, Edinburgh, 1978; pp. 247–253.

    Google Scholar 

  86. Glaser B, Vinik I, Valtyason G, Zoghlin G. Truncal vagotomy abolishes the somatostatin response to insulin-induced hypoglycemia in man.J Clin Endocrinol Metab 1981; 52: 823–825.

    PubMed  CAS  Google Scholar 

  87. Havel PJ, Parry SJ, Curry DL, Stern JS, Akpan JO, Gingerich RL. Autonomic nervous system mediation of the pancreatic polypeptide response to insulin-induced hypoglycemia in conscious rats.Endocrinology 1992; 130: 2225–2229.

    PubMed  CAS  Google Scholar 

  88. Havel PJ, Taborsky GJ Jr. The contribution of the autonomic nervous system to increased glucagon secretion during hypoglycemic stress: Update 1994.Endocr Rev 1994; 2(1): 201–204.

    Google Scholar 

  89. Henquin JC, Nenquin M. The muscarinic receptor subtype in mouse pancreatic B-cells.FEBS Lett 1988; 236: 89–92.

    PubMed  CAS  Google Scholar 

  90. Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV. Autonomic nervous control of pancreatic somatostatin secretion.Am J Physiol 1983; 245: E542–548.

    PubMed  CAS  Google Scholar 

  91. Johnson CD, Chayvialle JA, Devaux MA, Sarles H. Neural pathways for the release of gastrin, cholecystokinin, and pancreatic polypeptide after a meal in dogs: role of gastric and splanchnic nerves.Dig Dis Sci 1986; 31: 1361–1369.

    PubMed  CAS  Google Scholar 

  92. Kimura H, Katagiri K, Ohno T, Harada N, Imanishi H, Iwasaki M, Ito M, Takeuchi T. Effect of acetylcholine and new cholinergic derivatives on amylase output, insulin, glucagon and somatostatin secretion from the perfused isolated rat pancreas.Horm Metab Res 1982; 14: 356–360.

    Article  PubMed  CAS  Google Scholar 

  93. Ahren B, Veith RC, Paquette TL, Taborsky GJ Jr. Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 2) effects on basal release of somatostatin and pancreatic polypeptide.Endocrinology 1987; 121: 332–339.

    PubMed  CAS  Google Scholar 

  94. Ahren B, Vieth RC, Taborsky GJ Jr. Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1) effects on basal release of insulin and glucagon.Endocrinology 1987; 121: 323–331.

    PubMed  CAS  Google Scholar 

  95. Anderson PO, Holst JJ, Jarhult J. Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats.Acta Physiol Scand 1982; 116: 403–409.

    Google Scholar 

  96. Bloom SR, Edwards AV. The release of pancreatic glucagon and inhibition of insulin in response to stimulation of the sympathetic innervation.J Physiol (Lond) 1975; 253: 157–173.

    CAS  Google Scholar 

  97. Bloom SR, Edwards AV, Hardy RN. The role of the autonomic nervous system in the control of glucagon, insulin, and pancreatic polypeptide release from the pancreas.J Physiol (Lond) 1978; 280: 9.

    CAS  Google Scholar 

  98. Britton SW: Studies on the conditions of activity in endocrine glands. The nervous control of insulin secretion.Am J Physiol 1925; 24: 291–308.

    Google Scholar 

  99. deJong AJL, Klamer M, Jansen JBMJ, Lamers CBHW. Effect of atropine and somatostatin on bombesin-stimulated plasma gastrin, cholecystokinin and pancreatic polypeptide in man.Regul Pept 1987; 17: 285–293.

    CAS  Google Scholar 

  100. Girardier L, Seydoux J, Campfield LA. Control of A and B cells in vivo by sympathetic nervous input and selective hyper or hypoglycemia in dog pancreas.J de Physiol 1976; Paris, 72: 801–814.

    CAS  Google Scholar 

  101. Greenburg GR, Chan B, Nordgren SR, Alleyne J. Effect of vagal blockade on food- and hormone-stimulated release of pancreatic polypeptide and motilin in dogs.Dig Dis Sci 1985; 30: 946–953.

    Google Scholar 

  102. Hedo JA, Villanueva ML, Marco J. Stimulation of pancreatic polypeptide and glucagon secretion by 2-deoxy-d-glucose in man: evidence for cholinergic mediation.J Clin Endocrinol Metab 1978; 47: 366–371.

    PubMed  CAS  Google Scholar 

  103. Itoh M, Gerich JE. Adrenergic modulation of pancreatic somatostatin, insulin and glucagon secretion: Evidence for differential sensitivity of islet A, B, and D cells.Metabolism 1982; 31: 715–720.

    PubMed  CAS  Google Scholar 

  104. Kaneto A, Kajinuma H, Kosaka K. Effect of splanchnic nerve stimulation of glucagon and insulin output in the dog.Endocrinology 1975; 96: 143–150.

    PubMed  CAS  Google Scholar 

  105. Kaneto A, Miki E, Kosaka K. Effects of vagal stimulation on glucagon and insulin secretion.Endocrinology 1974; 95: 1005–1010.

    PubMed  CAS  Google Scholar 

  106. Karydakis P, Safioleas M, Papastratis G, Chalkiadakis GE, Simopoulous C, Livanou T, Miras C. Secretion of gastric acid, gastrin, and cyclic nucleotides in relation to the action of the vagus nerve.J de Chirurgie 1985; 122: 21–25.

    CAS  Google Scholar 

  107. Knigge U, Holst JJ, Knuhtsen S, Petersen B, Krarup T, Holst-Pedersen J, Christiansen PM. Gastrin-releasing peptide: Pharmacokinetics and effects on gastoenteropancreatic hormones and gastric secretion in normal men.J Clin Endocrinol 1984; 59: 310–315.

    CAS  Google Scholar 

  108. Krarup T, Schwartz TW, Hilsted J, Madsbad S, Overlaege O, Sestoft L. Impaired response of pancreatic polypeptide to hypoglycemia: An early sign of autonomic neuropathy in diabetics.Br Med J 1979; 2: 1544–1546.

    PubMed  CAS  Google Scholar 

  109. Larson GM, Sullivan HW, O’Dorisoo TM. Surgical sympathectomy increases pancreatic polypeptide response to food.Surgery 1985; 98: 236–242.

    PubMed  CAS  Google Scholar 

  110. Lindskog S, Ahren B. Galanin. Effects on basal and stimulated insulin and glucagon secretion in the mouse.Acta Physiol Scand 1987; 129: 305–309.

    PubMed  CAS  Google Scholar 

  111. Lindskog S, Ahren B. Galanin and pancreastatin inhibit stimulated insulin and glucagon secretion in the mouse: Comparison of effects.Horm Res 1988; 29: 237–240.

    PubMed  CAS  Google Scholar 

  112. Lovgren NA, Poulsen J, Schwartz TW. Impaired pancreatic innervation after selective gastric vagotomy.Scand J Gastroenterol 1981; 16: 811–816.

    Article  PubMed  CAS  Google Scholar 

  113. Lucey MR, Wass JAH, Fairclough P, Webb J, Webb S, Medbak S, Rees LH. Autonomic regulation of postprandial plasma somatostatin, gastrin and insulin.Gut 1985; 26: 683–688.

    PubMed  CAS  Google Scholar 

  114. Marliss EB, Girardier L, Seydoux J, Wollheim CB, Kanazawa Y, Orci L, Renold AE, Porte D Jr. Glucagon release induced by pancreatic nerve stimulation in the dog.J Clin Invest 1973; 52: 1246–1259.

    PubMed  CAS  Google Scholar 

  115. McDonald TJ, Dupre J, Greenberg GR, Tepperman F, Brooks B, Tatemoto K, Mutt V. The effect of galanin on canine plasma glucose and gastropancreatic hormone responses to oral nutrients and intravenous arginine.Endocrinology 1986; 119: 2340–2345.

    PubMed  CAS  Google Scholar 

  116. McDonald TJ, Dupre J, Tatemoto K, Greenberg GR, Radziuk J, Mutt V. Galanin inhibits insulin secretion and induces hyperglycemia in dogs.Diabetes 1985; 34: 192–196.

    PubMed  CAS  Google Scholar 

  117. Miller RE, Horton ES. Neural release of glucagon is inhibited by hyperglycemia and enhanced by phentolamine.Diabetes 1979; 28: 762–768.

    PubMed  CAS  Google Scholar 

  118. Palmer JP, Werner PL, Hollander B, Ensinck JW. Evaluation of the control of glucagon secretion by the parasympathetic nervous system in man.Metabolism 1979; 28: 549–552.

    PubMed  CAS  Google Scholar 

  119. Porte D Jr, Robertson RP. Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.Fed Proc 1973; 32: 1792–1796.

    PubMed  CAS  Google Scholar 

  120. Rizza R, Go V, Cryer P, Verdonk C, Gerich J. Stimulation of human pancreatic polypeptide secretion by hypoglycemia is independent of adrenergic mechanisms.J Clin Endocrinol Metab 1982; 55: 1234.

    PubMed  CAS  Google Scholar 

  121. Roy MW, Jones MS, Miller RE. Pancreatic somatostatin secretion is suppressed by splanchnic nerve stimulation.Diabetologia 1981; 20: 102–105.

    PubMed  CAS  Google Scholar 

  122. Roy MW, Lee KC, Jones MS, Miller RE. Neural control of pancreatic insulin and somatostatin secretion.Endocrinology 1984; 115: 770–775.

    PubMed  CAS  Google Scholar 

  123. Sakaguchi T, Tamaguchi K. Effects of vagal stimulation, vagotomy and adrenalectomy on release of insulin in the rat.J Endocrinol 1980; 85: 131–136.

    PubMed  CAS  Google Scholar 

  124. Sive AA, Vinik AI, Levitt N, Van Tonder S. Adrenergic modulation of human pancreatic polypeptide (hpp) release.Gastroenterology 1980; 79: 665–672.

    PubMed  CAS  Google Scholar 

  125. Svensson AM, Ostenson CG, Sandler S, Efendic S, Jannson L. Inhibition of nitric oxide synthase by NG-nitro-l-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats.Endocrinology 1994; 135: 849–853.

    PubMed  CAS  Google Scholar 

  126. Taborsky GJ Jr, Paquette TL, Pfeifer MA, Gingerich RL. Pentobarbital suppresses basal and reflexive pancreatic polypeptide release in dogs.Am J Physiol 1985; 249: E577.

    PubMed  CAS  Google Scholar 

  127. Tanaka Y, Seymour NE, Trachtenberg J, et al. Potentiation of carbachol-stimulated pancreatic polypeptide release by gastric inhibitory polypeptide and cholecystokinin (Abstr). Proceedings of the Twenty-First Annual Meeting Association of Academic Surgery, Orlando, FL, 50, 1987.

  128. Taylor IL, Feldman M, Richardson CT, Walsh JH. Gastric and cephalic stimulation of human pancreatic polypeptide release.Gastroenterology 1978; 78: 432–437.

    Google Scholar 

  129. Uvnas-Wallensten K, Roovete A, Johansson C, Efendic S. Decreased release of somatostatin into the portal vein following electrical stimulation in the cat.Acta Physiol Scand 1980; 109: 393–399.

    PubMed  CAS  Google Scholar 

  130. Wasada T, Dobbs RE, Harris V, Unger RH. Effect of 2-deoxy-d-glucose on plasma somatostatin levels in conscious dogs.Endocrinology 1981; 108: 1222–1227.

    PubMed  CAS  Google Scholar 

  131. Adrian TE, Bloom SR, Hermansen K, Iverson, J. Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas.Diabetologia 1978; 14: 413–417.

    PubMed  CAS  Google Scholar 

  132. Brunicardi FC, Druck P, Seymour NE, Sun YS, Gingerich RL, Elahi D, Andersen DK. Splanchnic neural regulation of pancreatic polypeptide release in the isolated perfused human pancreas.Am J Surg 1989; 157: 50–57.

    PubMed  CAS  Google Scholar 

  133. Brunicardi FC, Druck P, Seymour NE, Sun YS, Elahi D, Andersen DK. Selective neurohormonal interactions in islet cell secretion in the isolated perfused human pancreas,J Surg Res 1990; 48: 273–278.

    PubMed  CAS  Google Scholar 

  134. Brunicardi FC, Druck P, Sun YS, Elahi D, Gingerich RL, Andersen DK. Regulation of pancreatic polypeptide secretion in the isolated perfused human pancreas.Am J Surg 1988; 155: 63–69.

    PubMed  CAS  Google Scholar 

  135. Brunicardi FC, Goulet RJ, Sun YS, Berlin SA, Elahi D, Andersen DK. Neural and hormonal regulation of insulin and glucagon secretion in the isolated perfused human pancreas.Surg Forum 1984; 35: 214–217.

    CAS  Google Scholar 

  136. Hazelwood RL, Turner SD, Kimmel JR, Pollock HG. Spectrum of effects of a new polypeptide (third hormone?) isolated from the chicken pancreas.Gen Comp Endocrinol 1973; 21: 485–497.

    PubMed  CAS  Google Scholar 

  137. Hermansen K. Secretion of somatostatin from the normal and diabetic pancreas. Studies in vitro.Diabetologia 1980; 19: 492–504.

    PubMed  CAS  Google Scholar 

  138. Hermansen K. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas.Acta Endocrinol 1988; 119: 91–98.

    PubMed  CAS  Google Scholar 

  139. Hermansen K, Christensen SE, Orskov H. Characterization of somatostatin release from the pancreas. The role of calcium and acetylcholine.Diabetologia 1979; 16: 261–266.

    PubMed  CAS  Google Scholar 

  140. Holst JJ, Gronholt R, Schaffalitzky de Muckadell OB, Fahrenkrug J. Nervous control of pancreatic endocrine secretion in pigs: 1. Insulin and glucagon responses to electric stimulation of the vagus nerves.Acta Physiol Scand 1981; 111: 1–7.

    PubMed  CAS  Google Scholar 

  141. Holst JJ, Gronholt R, Schaffalitzky de Muckadell OB, Fahrenkrug J. Nervous control of pancreatic endocrine secretion in pigs: 2. The effect of pharmacologic blocking agent on the response to vagal stimulation.Acta Physiol Scand 1981; 111: 9–14.

    PubMed  CAS  Google Scholar 

  142. Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF. Effect of vagus, gastric inhibitory polypeptide and HCl on gastrin and somatostatin release from perfused pig antrum.Am J Physiol 1983; 244: G515–522.

    PubMed  CAS  Google Scholar 

  143. Holst JJ, Jensen SL, Nielsen OV, Schwartz TW. Oxygen supply, oxygen consumption, and endocrine and exocrine secretion of the isolated perfused porcine pancreas.Acta Physiol Scand 1980; 109: 7–13.

    PubMed  CAS  Google Scholar 

  144. Holst JJ, Jensen SL, Schaffalitzky de Muckadell OB, Fahrenkrug J. Secretin and vasoactive intestinal polypeptide in the control of the endocrine pancreas.Front Hormone Res 1980; 7: 119–131.

    CAS  Google Scholar 

  145. Holst JJ, Schwartz TW, Knuhtsen S, Jensen SL, Nielsen OV. Autonomic nervous control of the endocrine secretion from the isolated, perfused pig pancreas.J Auton Nerv Syst 1986; 17: 71–84.

    PubMed  CAS  Google Scholar 

  146. Honey RN, Weir GE. Acetylcholine stimulates insulin, glucagon and somatostatin release in the perfused chicken pancreas.Endocrinology 1980; 107: 1065–1068.

    PubMed  CAS  Google Scholar 

  147. Iversen J. Effect of acetylcholine on the secretion of glucagon and insulin from the isolated perfused canine pancreas.Diabetes 1973; 22: 381–387.

    PubMed  CAS  Google Scholar 

  148. Iversen J. Adrenergic receptors and the secretion of glucagon and insulin from the isolated, perfused canine pancreas.J Clin Invest 1973; 52: 2102–2116.

    PubMed  CAS  Google Scholar 

  149. Jensen SL, Fahrenkrug J, Holst JJ, Nielsen OV, Schaffalitzky de Muckadell OB. Secretory effects of VIP on isolated perfused porcine pancreas.Am J Physiol 1978; 235: E387–391.

    PubMed  CAS  Google Scholar 

  150. Kurose T, Tsuda K, Ishida H, Tsuji K, Okamoto Y, Tsuura Y, Kato S, Usami M, Imura H, Seino Y. Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro.Diabetologia 1992; 35(11): 1035–1041.

    PubMed  CAS  Google Scholar 

  151. Kwok YN, Verchere CB, McIntosh CHS, Brown JC. Effect of galanin on endocrine secretions from the isolated perfused rat stomach and pancreas.Eur J Pharmacol 1988; 146: 49–54.

    Google Scholar 

  152. McCullough AJ, Marshall JB, Bingham CP, Rice VI, Manning LD, Kalhan SC. Carbachol modulates GIP-mediated insulin release from rat pancreatic lobules in vitro.Am J Physiol 1985; 248: E299.

    PubMed  CAS  Google Scholar 

  153. Miralles P, Peiro E, Silvestre RA, Villaneuva ML, Marco J. Effects of galanin on islet cell secretory responses to VIP, GIP, CCK-8 and glucagon by the perfused rat pancreas.Metabolism 1988; 37: 766–770.

    PubMed  CAS  Google Scholar 

  154. Samols E, Stagner JI, Weir GC. Autonomic function and control of pancreatic somatostatin.Diabetologia 1981; 20: 338–392.

    Google Scholar 

  155. Samols E, Weir GC. Adrenergic modulation of pancreatic A, B, and D cells. Alpha-adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas.J Clin Invest 1979; 63: 230–238.

    PubMed  CAS  Google Scholar 

  156. Silvestre RA, Monge L, Miralles P, Moreno P, Villaneuva ML, Marco J. Effect of galanin, a new intestinal peptide, on pancreatic hormone secretion by the perfused rat pancreas.Diabetologia 1986; 29: 594A.

    Google Scholar 

  157. Sorenson RL, Elde RP, Seybold V. Effect of norepinephrine on insulin, glucagon and somatostatin secretion in isolated perfused rat islet.Diabetes 1979; 28: 899–904.

    PubMed  CAS  Google Scholar 

  158. Uvnas-Wallensten K, Nilsson G. A quantitative study of insulin release induced by vagal stimulation in anesthetized cats.Acta Physiol Scand 1978; 102: 137–142.

    PubMed  CAS  Google Scholar 

  159. Kerlavage AR, Fraser CM, Venter JC. Muscarinic cholinergic receptor structure; molecular biological support for subtypes.Trends Pharmacol Sci 1987; 8: 426–431.

    CAS  Google Scholar 

  160. Sergeyeva MA. Numerical changes of A- and B-cells of the islands of Langerhans produced by sympathetic and parasympathetic stimulation in the cat pancreas.Rev Can Biol 1943; 2: 495–500.

    Google Scholar 

  161. Porte D Jr. Sympathetic regulation of insulin secretion and its relation to diabetes mellitus.Arch Intern Med 1969; 123: 252–260.

    PubMed  CAS  Google Scholar 

  162. Wong KK, Symchowicz S, Staub MS, Tabachnick IIA. The in vitro effect of catecholamines, diazoxide and theophylline on insulin release.Life Sci 1967; 6: 2285–2291.

    PubMed  CAS  Google Scholar 

  163. Malaisse WJ. Hormonal and environmental modification of islet activity, inHandbook of Physiology. Endocrine Pancreas, American Physiology Society Washington, DC. 1972; sect. 7, vol. I, pp. 237–260.

    Google Scholar 

  164. Marre M, Bobbioni E, Sheppard M, Kronheim S, Miller J, Assan R. The nervous control of rat somatostatin, glucagon and insulin secretions.Diabete et Metabolisme 1982; 8: 179–186.

    PubMed  CAS  Google Scholar 

  165. Esterhuizen AC, Spriggs TLB, Lever JD. Nature of islet-cell innervation in the cat pancreas.Diabetes 1968; 17: 33–36.

    PubMed  CAS  Google Scholar 

  166. Kurose T, Seino Y, Nishi S, Tsuji K, Taminato T, Tsuda K, Imura H. Mechanism of sympathetic neural regulation of insulin, somatostatin and glucagon secretion.Am J Physiol 1990; 258: E220–227.

    PubMed  CAS  Google Scholar 

  167. Ahren B, Lundquist I. Secretin potentiates cholinergically induced glucagon secretion in the mouse.Acta Physiol Scand 1986; 128: 575–578.

    PubMed  CAS  Google Scholar 

  168. McIntyre N, Holdsworth CD, Turner DS. New interpretation of oral glucose tolerance.Lancet 1964; 2: 672,673.

    Google Scholar 

  169. Unger RH, Eisentraut AM. Entero-insular axis.Arch Intern Med 1969; 123: 261–266.

    PubMed  CAS  Google Scholar 

  170. Silvestre RA, Miralles P, Monge L, Moreno P, Villaneuva ML, Marco J. Effects of galanin on hormone secretion from the in situ perfused rat pancreas and on glucose production in rat hepatocytes in vitro.Endocrinology 1987; 121: 378–383.

    PubMed  CAS  Google Scholar 

  171. Takeda Y, Yanaihara C, Hashimoto Y, Yamamoto Y, Takeda R, Tatemoto K, Mutt V, Yanaihara N. Galanin effect on insulin and C-peptide release.Can J Physiol Pharmacol (Abstr) 1986; 95: 1356.

    Google Scholar 

  172. Schult FR, Pipeleers DG. Differences in adrenergic recognition by pancreatic A and B-cells.Science 1986; 232: 875.

    Google Scholar 

  173. Bauer FE, Ginsberg L, Venetikou M, Adrian TE, Bloom SR. Galanin: a possible diabetogenic peptide.Can J Physiol Pharmacol 1986; 96: 157–161.

    Google Scholar 

  174. Bauer FE, Venetikou M, Burrin JM, Ginsberg L, Mackay DJ, Bloom SR. Growth hormone release in man induced by galanin, a new hypothalamic peptide.Lancet 1986; ii: 192–194.

    Google Scholar 

  175. Floyd JC Jr. Human pancreatic polypeptide, inClinics in Endocrinology and Metabolism, vol. 8, Buchana DK, ed., WB Saunders, Philadelphia, 1977, pp. 379–394.

    Google Scholar 

  176. Lin TM, Chance RE. Spectrum gastrointestinal action of a new bovine pancreas polypeptide.Gastroenterology 1972; 62: 852.

    Google Scholar 

  177. Stefan Y, Orci L, Malaisse-Legae F, Perrelet A, Patel Y, Unger RH. Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans.Diabetes 1982; 31: 694–700.

    PubMed  CAS  Google Scholar 

  178. Ahren B, Paquette TL, Taborsky GJ Jr. Effect and mechanism of vagal nerve stimulation on somatostatin secretion in dogs.Am J Physiol 1986; 250: E212–217.

    PubMed  CAS  Google Scholar 

  179. Schwartz TW, Holst JJ, Fahrenkrug J, Kuhl C, Jensen SL, Nielsen OV, Schaffalitzky de Muckadell OB. Vagal, cholinergic regulation of the secretion of pancreatic polypeptide.J Clin Invest 1978; 61: 781–789.

    PubMed  CAS  Google Scholar 

  180. Stern N, Sowers JR, Taylor IL, Golub M. Dopaminergic modulation of meal-stimulated and circardian secretion of pancreatic polypeptide in man.J Clin Endocrinol Metab 1983; 56: 300–304.

    PubMed  CAS  Google Scholar 

  181. Thompson DA, Penicaud L, Welle SL, Jacobs LS. Pharmacological evidence for opioid and adrenergic mechanisms controlling growth hormone, prolactin, pancreatic polypeptide, and catecholamine levels in humans.Metabolism 1985; 34: 383–390.

    PubMed  CAS  Google Scholar 

  182. Adrian TE, Bloom SR, Besterman HS, Bryant MG. PP: physiology and pathology, inGut Hormones, Bloom SR, ed., Churchill Livingstone, Edinburgh, 1978; pp. 254–260.

    Google Scholar 

  183. Lonovics J, Guzman S, Devitt P, Hejtmancik KE, Suddith RL, Rayford PL, Thompson JC. Release of pancreatic polypeptide in humans by infusion of cholecystokinin.Gastroenterology 1980; 79: 817–822.

    PubMed  CAS  Google Scholar 

  184. Zawalich WS, Zawalich DK, Rasmussen H. Interactions between cholinergic agonists and enteric factors in the regulation of insulin secretion from isolated perfused rat islets.Acta Endocrinol 1989; 120: 702.

    PubMed  CAS  Google Scholar 

  185. Elahi D, McAllon-Dyke M, Clark B, et al. Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans.Am J Surg 1993; 165: 15–22.

    PubMed  CAS  Google Scholar 

  186. Watt PC, Ricordi C, Zeng Y, Kleinman R, Gingerich RL, Lloyd KCK, Brunicardi FC. Impaired glucose response following total pancreatectomy and islet cell autotransplantation in dogs.Trans Proc 1992; 24: 3026–3028.

    CAS  Google Scholar 

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  1. Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, 77030, Houston, TX

    F. Charles Brunicardi, David M. Shavelle & Dana K. Andersen

  2. Department of Surgery, UCLA School of Medicine, Los Angeles, CA

    F. Charles Brunicardi, David M. Shavelle & Dana K. Andersen

  3. Department of Surgery, Yale University School of Medicine, New Haven, CT

    F. Charles Brunicardi, David M. Shavelle & Dana K. Andersen

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Brunicardi, F.C., Shavelle, D.M. & Andersen, D.K. Neural regulation of the endocrine pancreas. Int J Pancreatol 18, 177–195 (1995). https://doi.org/10.1007/BF02784941

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