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Age-dependent aluminum accumulation in the human aorta and cerebral artery

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Abstract

The purpose of this study was to determine the extent of aluminum (Al) accumulation in the human aorta and cerebral arteries. The Al contents in the aortae and in the cerebral arteries from 23 human subjects was determined by inductively coupled plasma atomic emission spectrophotometry (ICP-AES). The subjects' age range was 45–99-yr-old; 15 of the subjects were males and 8 were females. Al was detected in twelve aortae and in six cerebral arteries, when the entire specimen was analyzed. Two specimens where Al was found in the cerebral arteries contained no Al in the aorta. No relationship to the subject's sex was found. When related to age, two groups were established. Group L (45–75 yr old) and group H (>75 yr old), which exhibited aortal Al concentrations of 33.3 and 72.7%, respectively. When the aortic wall was dissected into the tunica intima, media, and adventitia, Al was found mainly in the tunica media. In the aorta, significant relationships were found between Al and phosphorus (P) levels (r=0.801,p<0.01) and between Al and calcium (Ca) (r=0.661,p<0.05). We have concluded that Al accumulation is age-dependent and that it occurs both in the aorta and in the cerebral artery. In the aorta, accumulation occurs mainly in the tunica media. Both P and Ca appear to enhance aortal Al accumulation.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, 577, Higashi-Osaka, Osaka, Japan

    Takeshi Minami, Masayo Ichii & Yuko Okazaki

  2. Department of Anatomy, Nara Medical University, Kashihara, Nara, Japan

    Yoshiyuki Tohno, Setsuko Tohno, Masako Utsumi & Masa-oki Yamada

Authors
  1. Takeshi Minami
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  2. Masayo Ichii
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  3. Yoshiyuki Tohno
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  4. Setsuko Tohno
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  5. Masako Utsumi
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  6. Masa-oki Yamada
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  7. Yuko Okazaki
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Minami, T., Ichii, M., Tohno, Y. et al. Age-dependent aluminum accumulation in the human aorta and cerebral artery. Biol Trace Elem Res 55, 199–205 (1996). https://doi.org/10.1007/BF02784181

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  • DOI: https://doi.org/10.1007/BF02784181

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