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Selenium status of patients with Balkan endemic nephropathy

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Abstract

The selenium (Se) contents in common cereals in endemic and nonendemic areas in Serbia are very low. Plasma Se levels of both patients and healthy subjects, were also low, reflecting low Se intakes. Patients with Balkan endemic nephropathy (BEN) had significantly lower (p<0.05) plasma Se levels than healthy individuals, both from regions close to endemic areas, and from Belgrade. Mean plasma Se of BEN patients was slightly but insignificantly higher in samples taken immediately after dialysis than in those taken before, suggesting that very little of the Se present in plasma is dialyzable. Plasma SeGSH-Px activities before and after hemodialysis in both BEN and Nonendemic chronic renal failure (NCRF) patients were not significantly different, but BEN patients had lower enzyme activities than those with NCRF and healthy controls. In BEN patients, a significant correlation between plasma Se and SeGSH-Px activity was found.

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, Faculty of Veterinary Medicine, Bulevar JNA 18, 11000, Belgrade, Yugoslavia

    Momčilo Mihailović & Ivan Jovanović

  2. Department of Biochemistry, College of Veterinary Medicine, Hämeentie 57, SF-00550, Helsinki, Finland

    Paul Lindberg

  3. Center for Haemodialysis, 12000, Požarevac, Yugoslavia

    Duŝan Antić

Authors
  1. Momčilo Mihailović
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  2. Paul Lindberg
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  3. Ivan Jovanović
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  4. Duŝan Antić
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Additional information

NCFR patients were with diagnoses: TBC of kidneys, chronic glomerulonephritis, chronic pyelonephritis, and polycystic kidneys.

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Mihailović, M., Lindberg, P., Jovanović, I. et al. Selenium status of patients with Balkan endemic nephropathy. Biol Trace Elem Res 33, 71–77 (1992). https://doi.org/10.1007/BF02783994

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  • DOI: https://doi.org/10.1007/BF02783994

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