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Changes in free radicals, trace elements, and neurophysiological function in rats with liver damage induced byD-galactosamine

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Abstract

The changes in trace elements, free radicals, and neurophysiological function were investigated in rats with liver damage induced byd-galactosamine (GalN). The elevated results showed that all the parameters related to free radical metabolism changed after administration of GalN. Relative free radical concentration, malonaldehyde (MDA), and oxidized glutathione (GSSG) elevated, but reduced glutathione (GSH) decreased. Concurrently, zinc, copper, manganese, and selenium contents in liver were significantly reduced, whereas iron was elevated. In rats with hepatic encephalopathy (HE) owing to fulminant hepatic failure (FHF) induced by a high dosage of GalN, the latencies of VEPs were delayed. Moreover, there is a correlation between Zn content of brain and the latencies of VEPs. The results of this study suggested that lipid peroxidation by free radicals might be responsible for GalN-induced liver damage in which trace elements were involved, and that change in brain Zn might play a role in the neural inhibition of HE owing to FHF.

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Authors and Affiliations

  1. Department of Nutrition, Institute of Infectious Diseases, 26 Fengtai Road, 100039, Beijing, P. R. China

    Heng-Long Hu & Ren-Dun Chen

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  1. Heng-Long Hu
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  2. Ren-Dun Chen
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Hu, HL., Chen, RD. Changes in free radicals, trace elements, and neurophysiological function in rats with liver damage induced byD-galactosamine. Biol Trace Elem Res 34, 19–25 (1992). https://doi.org/10.1007/BF02783894

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  • DOI: https://doi.org/10.1007/BF02783894

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