Skip to main content
SpringerLink
Log in

Prevention by sodium 4,5-dihydroxybenzene1,3-disulfonate (tiron) of vanadium-induced behavioral toxicity in rats

  • Original Articles
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Recent studies have shown that oral vanadate (V5+) administration results in behavioral toxicity in rats. The chelating agent Tiron (sodium 4,5-dihydroxybenzene-l,3-disulfonate) is an effective antidote in the removal of vanadium from vanadium-loaded rats. In this study, the protective activity of Tiron on vanadate-induced behavioral toxicity was evaluated in adult rats. Intraperitoneal treatment with Tiron at 235 or 470 mg/kg was initiated after 6 wk of oral sodium metavanadate administration (16 mg/kg/d) and continued for 2 wk. Although vanadate exposure did not result in a significant reduction in the general activity of the animals in an open field, a lower active avoidance acquisition could be observed. However, the vanadate-induced behavioral deficit was reverted by Tiron administration at 470 mg/kg. The present results suggest that Tiron may protect, at least in part, against metavanadate-induced behavioral toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. K. Hope, A global biogeochemical budget for vanadium,Sci. Total Environ. 141, 1–10 (1994).

    Article  PubMed  CAS  Google Scholar 

  2. J. O. Nriagu and J. M. Pacyna, Quantitative assessment of worldwide contamination of air, water and soils by trace metals,Nature 333, 134–139 (1988).

    Article  PubMed  CAS  Google Scholar 

  3. D. J. Sanchez, A. Ortega, J. L. Domingo, and J. Corbella, Developmental toxicity evaluation of orthovanadate in the mouse,Biol. Trace Element Res. 30, 219–226 (1991).

    CAS  Google Scholar 

  4. J. L. Domingo, Vanadium: a review of the reproductive and developmental toxicity,Reprod. Toxicol. 10, 175–182 (1996).

    Article  PubMed  CAS  Google Scholar 

  5. M. H. Oster, J. M. Llobet, J. L. Domingo, J. B. German, and C. L. Keen, Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects,Toxicology 83, 115–130 (1993).

    Article  PubMed  CAS  Google Scholar 

  6. H. Zaporowska and W. Wasilewski, Hematological effects of vanadium on living organisms,Comp. Biochem. Physiol. 102C, 223–231 (1992).

    CAS  Google Scholar 

  7. M. A. Al-Bayati, S. N. Giri, O. G. Raabe, L. S. Rosenblatt, and M. Shifrine, Time and dose-response study of the effects of vanadate on rats: morphological and biochemical changes in organs,J. Environ. Pathol. Toxicol. Oncol. 9, 435–39 (1989).

    PubMed  CAS  Google Scholar 

  8. J. L. Domingo, M. Gomez, D. J. Sanchez, J. M. Llobet, J. Corbella, and C. L. Keen, The marked improvement of glucose homeostasis by oral vanadate or vanadyl treatment in streptozotocin-induced diabetic rats may be related to the anorexic effects of vanadium,Trace Element Electr. 11, 16–22 (1994).

    CAS  Google Scholar 

  9. C. E. Heyliger, A. G. Tahiliani, and J. H. McNeill, Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats,Science 227, 1474–1477 (1985).

    Article  PubMed  CAS  Google Scholar 

  10. A. M. Kordowiak, R. Trzos, and R. Grybos, Insulin-like effects on liver Golgi membrane preparations of bis(oxalato)oxovanadate(IV) complex ion, a new vanadate compound,Horm. Metab. Res. 29, 101–105 (1997).

    PubMed  CAS  Google Scholar 

  11. A. K. Srivastava, Potential use of vanadium compounds in the treatment of diabetes mellitus,Exp. Opin. Invest. Drugs 4, 525–536 (1995).

    CAS  Google Scholar 

  12. E. Tsiani and I. G. Fantus, Vanadium compounds. Biological actions and potential as pharmacological agents,Trends Endocrinol. Metab. 8, 51–58 (1997).

    Article  CAS  PubMed  Google Scholar 

  13. J. Yao, M. L. Battell, and J. H. McNeill, Acute and chronic response to vanadium following two methods of streptozotocin-diabetes induction,Can. J. Physiol. Pharmacol. 75, 83–90 (1997).

    Article  PubMed  CAS  Google Scholar 

  14. J. L. Domingo, M. Gomez, J. M. Llobet, J. Corbella, and C. L. Keen, Oral vanadium administration to streptozotocin-diabetic rats has marked negative side effects which are independent of the form of vanadium used,Toxicology 66, 279–287 (1991).

    Article  PubMed  CAS  Google Scholar 

  15. J. L. Domingo, M. Gomez, J. M. Llobet, J. Corbella, and C. L. Keen, Improvement of glucose homeostasis by oral vanadyl or vanadate treatment in diabetic rats is accompanied by negative side effects,Pharmacol. Toxicol. 68, 249–253 (1991).

    PubMed  CAS  Google Scholar 

  16. J. L. Domingo, M. Gomez, D. J. Sanchez, J. M. Llobet, and C. L. Keen, Toxicology of vanadium compounds in diabetic rats: the action of chelating agents on vanadium accumulation,Mol. Cell. Biochem. 153, 233–240 (1995).

    Article  PubMed  CAS  Google Scholar 

  17. G. J. Naylor and A. H. W. Smith, Defective control of sodium-pump density in manic depresive psychosis,Psychol. Med. 11, 257–263 (1981).

    Article  PubMed  CAS  Google Scholar 

  18. G. J. Naylor, A. H. W. Smith, D. Bryce-Smith, and N. I. Ward, Elevated vanadium content of hair and mania,Biol. Psychiat. 19, 759–764 (1984).

    PubMed  CAS  Google Scholar 

  19. G. J. Naylor and A. H. W. Smith, Vanadium: a possible etiological factor in manic depressive illness,Psychol. Med. 11, 249–256 (1981).

    Article  PubMed  CAS  Google Scholar 

  20. G. J. Naylor, F. M. Corrigan, A. H. W. Smith, P. Conelly, and N. I. Ward, Further studies of vanadium in depressive psychosi,Br. J. Psychiat. 150, 656–661 (1987).

    CAS  Google Scholar 

  21. D. J. Sanchez, M. T. Colomina, and J. L. Domingo, Effects of vanadium on activity and learning in rats,Physiol. Behav. 63, 345–350 (1998).

    Article  PubMed  CAS  Google Scholar 

  22. B. R. Nechay, Mechanisms of action of vanadium,Ann. Rev. Pharmacol. Toxicol. 24, 501–524 (1984).

    Article  CAS  Google Scholar 

  23. J. M. Llobet and J. L. Domingo, Acute toxicity of vanadium compounds in rats and mice,Toxicol. Lett. 23, 227–231 (1984).

    Article  PubMed  CAS  Google Scholar 

  24. M. Gomez, J. L. Domingo, J. M. Llobet, and J. Corbella, Effectiveness of some chelating agents on distribution and excretion of vanadium in rats after prolonged oral administration,J. Appl. Toxicol. 11, 195–198 (1991).

    Article  PubMed  CAS  Google Scholar 

  25. M. Gomez, J. L. Domingo, J. M. Llobet, and J. Corbella, Evaluation of the efficacy of various chelating agents on urinary excretion and tissue distribution of vanadium in rats,Toxicol. Lett. 57, 227–234 (1991).

    Article  PubMed  CAS  Google Scholar 

  26. Z. Zhu, M. Tepel, and W. Zidek, Vanadate inhibits actions on Ca2+ handling in vascular smooth muscle cells,Trace Element Electr. 13, 109–113 (1996).

    CAS  Google Scholar 

  27. C. M. Vescina, V. C. Salice, A. M. Cortizo, and S. B. Etcheverry, Effect of vanadium compounds on acid phosphatase activity,Biol. Trace Element Res. 53, 185–191 (1996).

    Article  CAS  Google Scholar 

  28. G. J. Naylor, Vanadium and affective disorders,Biol. Psychiat. 18, 103–112 (1983).

    PubMed  CAS  Google Scholar 

  29. D. S. G. Kay, G. J. Naylor, A. H. W. Smith, and C. Greenwood, The therapeutic effect of ascorbic acid and EDTA in manic-depressive psychosis: double-blind comparisons with standard treatments,Psychol. Med. 14, 533–539 (1984).

    PubMed  CAS  Google Scholar 

  30. D. Witkowska and J. Brzezinski, Alteration of brain noradrenaline, dopamine and 5-hydroxytryptamine levels during vanadium poisoning,Polish J. Pharmacol. Pharm. 31, 393–398 (1979).

    CAS  Google Scholar 

  31. J. L. Domingo, M. A. Bosque, M. Luna, and J. Corbella, Prevention by Tiron (sodium 4,5-dihydroxybenzene-l,3-disulfonate) of vanadate-induced developmental toxicity in mice,Teratology 48, 133–138 (1993).

    Article  PubMed  CAS  Google Scholar 

  32. J. L. Domingo, M. Gomez, D. J. Sanchez, J. M. Llobet, and C. L. Keen, Tiron administration minimizes the toxicity of vanadate but not its insulin mimetic properties in diabetic rats,Life Sci. 50, 1311–1318 (1992).

    Article  PubMed  CAS  Google Scholar 

  33. J. L. Domingo, D. J. Sanchez, M. Gomez, J. M. Llobet, and J. Corbella, Oral vanadate and Tiron treatment of diabetes mellitus in rats: Improvement of glucose homeostasis and negative side effects,Vet. Hum. Toxicol. 35, 495–500 (1993).

    PubMed  CAS  Google Scholar 

  34. A. Ortega, D. J. Sanchez, J. J. Domingo, J. M. Llobet, and J. Corbella, Developmental toxicity evaluation of Tiron (sodium 4,5-dihydroxybenzene-l,3-disulfonate) in mice,Res. Commun. Chem. Pathol. Pharmacol. 73, 97–106 (1991).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Toxicology and Environmental Health, School of Medicine, “Rouira i Virgili” University, San Lorenzo 21, 43201, Reus

    Domenec J. Sanchez, Jose L. Domingo & Jacint Corbella

  2. Psychobiology Unit, “Rovira i Virgili” University, 43007, Tarragona, Spain

    M. Teresa Colomina

Authors
  1. Domenec J. Sanchez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Teresa Colomina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jose L. Domingo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jacint Corbella
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sanchez, D.J., Colomina, M.T., Domingo, J.L. et al. Prevention by sodium 4,5-dihydroxybenzene1,3-disulfonate (tiron) of vanadium-induced behavioral toxicity in rats. Biol Trace Elem Res 69, 249–259 (1999). https://doi.org/10.1007/BF02783877

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02783877

Index entries

Search

Navigation