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An elemental correlation study in cancerous breast tissue by total reflection x-ray fluorescence

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Abstract

The total reflection x-ray fluorescence method (TRXRF) has been employed to determine of P, S, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Se, Rb, Sr, and Pb concentration in the benign breast tumor tissue from 68 women and in the cancerous breast tissue from 26 women. Concentrations of most of elements show enhancement in cancerous breast tissue. Examined elements compete for binding sites in the cell, change its enzymatic activity, and exert direct or indirect action on the carcinogenic process accelerating the growth of rumors. Inhibition of enzymatic activity caused by variation in trace element concentrations results in immunological breakdown of the body system. An attempt has been made to correlate measured trace element concentrations with the clinical stage of cancer. Physical bases of used analytical method, experimental setup, and the procedure of sample preparation are described.

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Authors and Affiliations

  1. Holy cross Cancer Center, 25-734 Kielce, Artwińskiego 3, Poland

    Urszula Majewska, Janusz Braziewicz, Dariusz BanaŚ, Aldona Kubala-KukuŚ, Stanisław Góźdź, Jolanta Smok & Antoinette CJrbaniak

  2. Institute of Physics, Pedagogical University, 25-509 Kielce, Lesna 16, Poland

    Urszula Majewska, Janusz Braziewicz, Dariusz BanaŚ, Aldona Kubala-KukuŚ & Marek Pajek

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  1. Urszula Majewska
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  2. Janusz Braziewicz
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  3. Dariusz BanaŚ
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  4. Aldona Kubala-KukuŚ
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  5. Stanisław Góźdź
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  6. Marek Pajek
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  7. Jolanta Smok
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  8. Antoinette CJrbaniak
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Majewska, U., Braziewicz, J., BanaŚ, D. et al. An elemental correlation study in cancerous breast tissue by total reflection x-ray fluorescence. Biol Trace Elem Res 60, 91–100 (1997). https://doi.org/10.1007/BF02783312

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  • DOI: https://doi.org/10.1007/BF02783312

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