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Structure, function and expression of voltage-dependent sodium channels

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Abstract

Voltage-dependent sodium channels control the transient inward current responsible for the action potential in most excitable cells. Members of this multigene family have been cloned, sequenced, and functionally expressed from various tissues and species, and common features of their structure have clearly emerged. Site-directed mutagenesis coupled with in vitro expression has provided additional insight into the relationship between structure and function. Subtle differences between sodium channel isoforms are also important, and aspects of the regulation of sodium channel gene expression and the modulation of channel function are becoming topics of increasing importance. Finally, sodium channel mutations have been directly linked to human disease, yielding insight into both disease pathophysiology and normal channel function. After a brief discussion of previous work, this review will focus on recent advances in each of these areas.

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Authors and Affiliations

  1. Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA

    Roland G. Kallen, Sidney A. Cohen & Robert L. Barchi

  2. Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Roland G. Kallen

  3. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Sidney A. Cohen

  4. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Robert L. Barchi

  5. Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA

    Roland G. Kallen, Sidney A. Cohen & Robert L. Barchi

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Kallen, R.G., Cohen, S.A. & Barchi, R.L. Structure, function and expression of voltage-dependent sodium channels. Mol Neurobiol 7, 383–428 (1993). https://doi.org/10.1007/BF02769184

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