Skip to main content
SpringerLink
Log in

Comparison of the effects of three haemodialysis membranes on vancomycin disposition

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Polysulfone (PSF) and polyacrylonitrile (PAN) were recently introduced haemodialysis (HD) membranes. The effect of each on vancomycin disposition was compared with cuprophan (SCE) in 12 chronic HD patients who received 14 infusions. Vancomycin (1 g) was infused over 1 hour, followed by three 4-hour HD sessions over 5 days, beginning 1 hour after the end of infusion. The intradialytic clearances of vancomycin were 73, 54 and 15 ml/min for PSF, PAN and SCE, respectively. At the end of the third HD session, vancomycin concentration dropped to subtherapeutic level (<7.5 μg/ml) only in patients dialysed with PSF and PAN. The corresponding elimination half-lives (t1/2β) were 61, 60 and 86 hours for the three membranes, respectively. According to these findings, vancomycin should be given every three HD sessions for PSF and PAN. The dosage interval should be extended up to every 5 HD sessions for patients on SCE. The peak (mean±S.D.) obtained one hour after the end of infusion was 34.2±11.4 μg/ml, which is within the therapeutic range.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bierman, M. H., Needham-Walker, C. A., Hammeke, M., Egan, J. D.: Vancomycin therapy for serious staphylococcal infections in chronic hemodialysis patients.J. Dialysis, 4, 179 (1980).

    Article  CAS  Google Scholar 

  2. Matzke, G. R., Zhanel, G. G., Guay, D. R. P.: Clinical pharmacokinetics of vancomycin.Clin. Pharmacol., 11, 257 (1986).

    Article  CAS  Google Scholar 

  3. Eykyn, S., Phillips, I., Evans, J.: Vancomycin for staphylococcal shunt site infections in patients on regular hemodialysis.Br. Med. J., 3, 80 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Masur, H., Francioli, P., Ruddy, M., Murray, H. W.: Vancomycin serum levels and toxicity in chronic hemodialysis patiens with Staphylococcus aureus bacteremia.Clin. Nephrol., 20, 85 (1983).

    CAS  PubMed  Google Scholar 

  5. Cunha, B. A., Quintiliani, R., Deglin, J. M., Izard, M. W., Nightingale, C. H.: Pharmacokinetics of vancomycin in anuria.Rev. Infect Dis., 3 (Suppl.), S269 (1981).

    Article  CAS  Google Scholar 

  6. Basile, C., Drueke, T.: Dialysis membranes biocompatibility.Nephron, 52, 113 (1989).

    Article  CAS  PubMed  Google Scholar 

  7. Bastani, B., Spyker, D. A., Minocha, A., Cummings, R., Westervelt, F. B.: In vivo comparison of three different hemodialysis membranes for vancomycin clearance Cuprophan, Cellulose acetate and Polyacrylonitrile.Dial. Transplant., 17, 527 (1988).

    Google Scholar 

  8. Lanese, D. M., Alfrey, P. S., Molitoris, B. A.: Markedly increased clearance of vancomycin during hemodialysis using polysulfone dialysers.Kidney Int., 35, 1409 (1989).

    Article  CAS  PubMed  Google Scholar 

  9. Matzke, G. R., Mcgory, R. W., Halstenson, C. E., Keane, W. F.: Pharmacokinetics of vancomycin in patients with various degrees of renal function.Antimicrob. Agent Chemother., 25, 433 (1984).

    Article  CAS  Google Scholar 

  10. Bohler, J., Reetze, P., Keller, E., Kramer, A., Schollmeyer, P. J.: Rebound plasma vancomycin levels after hemodialysis with highly permeable membranes.Eur. J. Clin. Pharmacol., 42, 635 (1992).

    Article  CAS  PubMed  Google Scholar 

  11. Levy, G., Gibson, J. P., Whitman, W., Procknal, J.: Hemodialysis clearance of theophylline.J. Am. Med. Assoc., 237, 1466 (1977).

    Article  CAS  Google Scholar 

  12. Tan, C. C., Lee, H. S., Ti, T. Y., Lee, E. J. C.: Pharmacokinetics of intravenous vancomycin in patients with end-stage renal failure.Ther. Drug Monit., 12, 129 (1990).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

    J. Alwakeel, S. Huraib & H. Abu-Aisha

  2. Department of Clinical Pharmacy College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

    T. A. Najjar

  3. Department of Pharmacology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

    M. J. Al-Yamani & A. Al-Haider

  4. College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    J. Alwakeel, T. A. Najjar, M. J. Al-Yamani, S. Huraib, A. Al-Haider & H. Abu-Aisha

Authors
  1. J. Alwakeel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. A. Najjar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. J. Al-Yamani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Huraib
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Al-Haider
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Abu-Aisha
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alwakeel, J., Najjar, T.A., Al-Yamani, M.J. et al. Comparison of the effects of three haemodialysis membranes on vancomycin disposition. Int Urol Nephrol 26, 223–228 (1994). https://doi.org/10.1007/BF02768291

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02768291

Keywords

Search

Navigation