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Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients

  • Clinical and Epidemiological Studies
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Summary

The plasma levels of HIV-1 RNA, tumor necrosis factor alpha (TNF-α), soluble receptors type II of TNF-α (sTNF-α RII), soluble receptors of interleukin-4 (sR IL-4), interleukin-6 (IL-6), soluble receptors of interleukin-6 (sR IL-6), granulocyte macrophage colony stimulating factor (GM-CSF), soluble receptors of GM-CSF (sR GM-CSF), RANTES, MIP-1α and MIP-1β were measured in 80 HIV-infected patients. All patients had not been treated previously with antiretroviral drugs and did not present a recent history of opportunistic infection. A statistically significant correlation was found between HIV-1 RNA and TNF-α (p=0.005) or sTNF-α RII levels (p<0.001). RANTES and MIP-1α levels did not correlate with HIV-1 RNA. MIP-1β levels were correlated with plasma RNA titers in patients with CD4+ T cells <200 × 106/l (p=0.03). MIP-1α and sR IL-4 levels were significantly different according to the CD4+ T cell range (p=0.003 and p=0.0002, respectively). GM-CSF and sR GM-CSF were undetectable in each case. These data confirm that HIV-1 replication in the plasma is correlated with TNF-α levels, but do not show a clear correlation with levels of the chemokines studied.

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References

  1. Poli, G., Fauci, A. S.: Cytokine cascades in HIV infection. In: Gupta, S. (ed.), Immunology of HIV infection. Plenum Press, New York 1996, pp. 285–301.

    Google Scholar 

  2. Wyakarnam, A., McKeating, J., Meager, A., Beverley, P. C.: Tumour necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication. AIDS 4 (1990) 21–27.

    Article  Google Scholar 

  3. Cocchi, F., DeVico, A. L., Garzino-Demo, A., Arya, S. K., Gallo, R. C., Lusso, P.: Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8_ T cells. Science 270 (1995) 1811–1815.

    Article  PubMed  CAS  Google Scholar 

  4. Cohen, J.: Chemokines share center stage with drug therapies. Science 273 (1996) 302–303.

    PubMed  Google Scholar 

  5. Thea, D. M., Porat, R., Nagimbi, K., Baangi, M., St. Louis, M. E., Kaplan, G., Dinarello, C. A., Keusch, G. T.: Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann. Intern. Med. 124 (1996) 757–762.

    PubMed  CAS  Google Scholar 

  6. Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Detsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn B. H., Saag, M. S., Shaw, G. M.: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373 (1995) 117–122.

    Article  PubMed  CAS  Google Scholar 

  7. Mellors, J. W., Kingsley, L. A., Rinaldo, C. R., Todd, J. A., Hoo, B. S., Kokka, R. P., Gupta, P.: Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann. Intern. Med. 122 (1995) 573–579.

    PubMed  CAS  Google Scholar 

  8. Zanussi, S., D'Andrea, M., Simonelli, C., Tirelli, U., De Paoli, P.: Serum levels of RANTES and MIP-1α in HIV-positive long-term survivors and progressor patients. AIDS 10 (1996) 1431–1432.

    Article  PubMed  CAS  Google Scholar 

  9. Salazar-Gonzalez, J. F., Martinez-Maza, O., Aziz, N., Kolberg, J. A., Yeghiazarian, T., Shen, L.-P., Fahey, J. L.: Relationship of plasma HIV-RNA levels and levels of TNF-α and immune activation products in HIV infection. Clin. Immunol. Immunopathol. 84 (1997) 36–45.

    Article  PubMed  CAS  Google Scholar 

  10. Barcellini, W., Rizzardi, G. P., Poli, G., Tambussi, G., Velati, C., Meroni, P. L., Lazzarin, A.: Cytokines and soluble receptor changes in the transition from primary to early chronic HIV type 1 infection. AIDS Res. Hum. Retroviruses 12 (1996) 325–331.

    PubMed  CAS  Google Scholar 

  11. Gotfried, M. H., van der Pol, T., Weverling, G. J., Mulder, J. W., Jansen, J., Van Deventer, S. J., Sauerwein, H. P.: Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection. J. Infect. Dis. 169 (1994) 739–745.

    Google Scholar 

  12. Bilello, J. A., Stellrecht, K., Drusano, G. L., Stein, D. S.: Soluble tumor necrosis factor-α receptor type II (sTNF-α RII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients. J. Infect. Dis. 173 (1996) 464–467.

    PubMed  CAS  Google Scholar 

  13. Cremoni, L., Vaira, L. L., D'Amico, P., Grassi, M. G., Milazo, F.: Does zidovudine reduce tumour necrosis factor-α in HIV-positive patients? AIDS 7 (1993) 128–129.

    Article  PubMed  CAS  Google Scholar 

  14. Li, Q., Gebhard, K., Schacker, T., Henry, K., Haase, A. T.: The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue. J. Virol. 71 (1997) 7080–7082.

    PubMed  CAS  Google Scholar 

  15. Klausner, J. D., Makonkawkeyoon, S., Akarasewi, P., Nakata, K., Kasinrerk, W., Corral, L., Dewar, R. L., Lane, H. C., Freedman, V. H., Kaplan, G.: The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 andMycobacterium tuberculosis infection. J. Acquir. Immune Defic. Syndr. 11 (1996) 247–257.

    CAS  Google Scholar 

  16. Walker, R. E., Spooner, K. M., Kelly, G., McCloskey, R. V., Woody, J. N., Falloon, J., Baseler, M., Piscitelli, S. C., Davey, R. T. Jr.,Polis, M. A., Kovacs, J. A., Masur, H., Lane, H. C.: Inhibition of immunoreactive tumor necrosis factor-α by a chimeric antibody in patients infected with human immunodeficiency virus type 1. Infect. Dis. 174 (1996) 63–68.

    CAS  Google Scholar 

  17. Navikas, V., Link, J., Persson, C., Olsson, T., Hojeberg, B., Ljungdahl, A., Link, H., Wahren, B.: Increased mRNA expression of IL-6, IL-10, TNF-alpha, and perforin in blood mononuclear cells in human HIV infection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 9 (1995) 484–489.

    PubMed  CAS  Google Scholar 

  18. Bisset, L. R., Rothen, M., Joller-Jemelka, H. I., Dubs, R. W., Grob, P. J., Opravil, M.: Changes in circulating levels of the chemokines macrophage inflammatory proteins 1 α and 1 β, RANTES, monocyte chemotactic protein-1 and interleukin-16 following treatment of severely immunodeficient HIV-infected individuals with indinavir. AIDS 11 (1997) 485–491.

    Article  PubMed  CAS  Google Scholar 

  19. Cook, D. N.: The role of MIP-1 alpha in inflammation and hematopoiesis. J. Leukoc. Biol. 59 (1996) 61–66.

    PubMed  CAS  Google Scholar 

  20. Zhou, Z., Kim, Y. T., Pollok, K., Hurtado, J., Lee, J. K., Broxmeyer, H. E., Kwon, B. S.: Macrophage inflammatory protein-1 alpha rapidly modulates its receptors and inhibits the anti-CD3 mAb-mediated proliferation of T lymphocytes. J. Immunol. 151 (1993) 4333–4341.

    PubMed  CAS  Google Scholar 

  21. Klinger, M. H., Wilhelm, D., Bubel, S., Sticherling, M., Schroder, J. M., Kuhnel, W.: Immunocytochemical localization of the chemokines RANTES and MIP-1 alpha within human platelets and their release during storage. Int. Arch. Allergy Immunol. 104 (1995) 541–546.

    Article  Google Scholar 

  22. Blazevic, V., Heino, M., Jussila, T., Krohn, K. J. E.: RANTES, MIP and interleukin-16 in HIV infection. AIDS 10 (1996) 1435–1436.

    PubMed  CAS  Google Scholar 

  23. Smith, M. W., Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Lomb, D. A., Goedert, J. J., O'Brien, T. R., Jacobson, L. P., Kaslow, R., Buchbinder, S., Vittinghoff, E., Vlahov, D., Hoots, K., Hilgartner, M. W., Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort, O'Brien, S. J.: Contrasting genetic influence ofCCR2 andCCR5 variants on HIV-1 infection and disease progression. Science 277 (1997) 959–965.

    Article  PubMed  CAS  Google Scholar 

  24. Pantaleo, G.: How immune-based interventions can change HIV therapy. Nature Med. 3 (1997) 483–486.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Infectious Diseases, Hôpital chalucet, F-83056, Toulon, France

    G. Hittinger M. D. & A. Lafeuillade M. D.

  2. Laboratory of Virology, Hôpital Chalucet, F-83056, Toulon, France

    C. Poggi Ph.D. & N. Profizi Ph.D.

  3. Laboratory of Biology, Hôpital Chalucet, F-83056, Toulon, France

    E. Delbeke M. D.

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  1. G. Hittinger M. D.
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  2. C. Poggi Ph.D.
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  3. E. Delbeke M. D.
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  4. N. Profizi Ph.D.
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Hittinger, G., Poggi, C., Delbeke, E. et al. Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients. Infection 26, 100–103 (1998). https://doi.org/10.1007/BF02767768

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  • DOI: https://doi.org/10.1007/BF02767768

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