Abstract
Four different prophylactic regimen were tried in a group of 120 children, admitted for first attack of febrilc seizures, and followed up for a period of 5–6 years. The most effective regimen found to be, was with antipyretic and diazepam during the period of febrile illness. Continuous, as well as intermittent phenobarbitone therapy was found to be ineffective in preventing recurrence.
Similar content being viewed by others
References
Ouellette EM: The child who convulses with fever. Pediatr Clin North Am 21: 467, 1974
Frantzen E, Lennox-Buchthal M, Nygarrd A: A genetic study of febrile convulsions. Neurol 20: 909, 1970
Lennox-Buchthal M: Febrile convulsions, a reappraisal, EEG Clin. Neurophysiol suppl 32: 138, 1973
Ramakrishnan K, Mathew KN, Kurian Thomas: Causes of fever in febrile seizures. Indian J Pediatr 49: 367, 1982
Livingston S: Febrile convulsions, comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C Thomas, Springfield, Illinois, 1972 p 16
Millichap JG: Febrile convulsions. New York, Mac Millan, 1968
Livingston S: Infantile febrile convulsions. Devel Med Child Neurol 10: 374, 1968
Faero O: Kastrup KW, Nelsen EL et al.: Successful prophylaxis of febrile convulsions with phenobarbital. Epilepsia 13: 279, 1972
Buchthal F, Lennox-Buchthal MA: Phenobarbital, relation of serum concentrations to control of seizures. In woodsburry DM ed: Antiepileptic drugs. NY, Ravenpress, 1972, p 335
Svenmark O, Buchthal F: Diphenyl hydantion and phenobarbital serum level in children. Amer J Dis Child 108: 82, 1964
Wallace J, Aldrige Smith J: Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone. Br Med J 280: 353, 1980
Heckmatt JZ, Houstom AB, Clow BJ et al: Failure of phenobarbitone to prevent febrile convulsions. Br Med J 1: 559, 1976
Bacon CJ, Mucklow JC, Rawlins MD et al: Placebo controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions. Lancet Sept. 19, p 600, 1981
Vanden Berg BJ, Yeru Shalmy J: Studies on convulsive disorders in young children. J Pediat 79: 1004, 1971
Hoppu K, Santavuori P: Diazepam rectal solution for home treatment of acute seizures in children. Acta Paediatr Scand 70: 369, 1981
Knudsen FU: Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and Children. Arch Dis Child 54: 855, 1979.
Knudsen FU, Vestermark S: Prophylactic diazepam or phenobarbitone in febrile convulsions, a prospective controlled study. Arch Dis Child 53: 660, 1978
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ramakrishnan, K., Thomas, K. Long term prophylaxis of febrile seizures. Indian J Pediatr 53, 397–400 (1986). https://doi.org/10.1007/BF02760422
Issue Date:
DOI: https://doi.org/10.1007/BF02760422