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Long term prophylaxis of febrile seizures

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Abstract

Four different prophylactic regimen were tried in a group of 120 children, admitted for first attack of febrilc seizures, and followed up for a period of 5–6 years. The most effective regimen found to be, was with antipyretic and diazepam during the period of febrile illness. Continuous, as well as intermittent phenobarbitone therapy was found to be ineffective in preventing recurrence.

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References

  1. Ouellette EM: The child who convulses with fever. Pediatr Clin North Am 21: 467, 1974

    PubMed  CAS  Google Scholar 

  2. Frantzen E, Lennox-Buchthal M, Nygarrd A: A genetic study of febrile convulsions. Neurol 20: 909, 1970

    CAS  Google Scholar 

  3. Lennox-Buchthal M: Febrile convulsions, a reappraisal, EEG Clin. Neurophysiol suppl 32: 138, 1973

    Google Scholar 

  4. Ramakrishnan K, Mathew KN, Kurian Thomas: Causes of fever in febrile seizures. Indian J Pediatr 49: 367, 1982

    Google Scholar 

  5. Livingston S: Febrile convulsions, comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C Thomas, Springfield, Illinois, 1972 p 16

    Google Scholar 

  6. Millichap JG: Febrile convulsions. New York, Mac Millan, 1968

    Google Scholar 

  7. Livingston S: Infantile febrile convulsions. Devel Med Child Neurol 10: 374, 1968

    Article  CAS  Google Scholar 

  8. Faero O: Kastrup KW, Nelsen EL et al.: Successful prophylaxis of febrile convulsions with phenobarbital. Epilepsia 13: 279, 1972

    Article  PubMed  CAS  Google Scholar 

  9. Buchthal F, Lennox-Buchthal MA: Phenobarbital, relation of serum concentrations to control of seizures. In woodsburry DM ed: Antiepileptic drugs. NY, Ravenpress, 1972, p 335

    Google Scholar 

  10. Svenmark O, Buchthal F: Diphenyl hydantion and phenobarbital serum level in children. Amer J Dis Child 108: 82, 1964

    Google Scholar 

  11. Wallace J, Aldrige Smith J: Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone. Br Med J 280: 353, 1980

    Article  PubMed  CAS  Google Scholar 

  12. Heckmatt JZ, Houstom AB, Clow BJ et al: Failure of phenobarbitone to prevent febrile convulsions. Br Med J 1: 559, 1976

    PubMed  CAS  Google Scholar 

  13. Bacon CJ, Mucklow JC, Rawlins MD et al: Placebo controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions. Lancet Sept. 19, p 600, 1981

  14. Vanden Berg BJ, Yeru Shalmy J: Studies on convulsive disorders in young children. J Pediat 79: 1004, 1971

    Article  Google Scholar 

  15. Hoppu K, Santavuori P: Diazepam rectal solution for home treatment of acute seizures in children. Acta Paediatr Scand 70: 369, 1981

    PubMed  CAS  Google Scholar 

  16. Knudsen FU: Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and Children. Arch Dis Child 54: 855, 1979.

    PubMed  CAS  Google Scholar 

  17. Knudsen FU, Vestermark S: Prophylactic diazepam or phenobarbitone in febrile convulsions, a prospective controlled study. Arch Dis Child 53: 660, 1978

    PubMed  CAS  Google Scholar 

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Ramakrishnan, K., Thomas, K. Long term prophylaxis of febrile seizures. Indian J Pediatr 53, 397–400 (1986). https://doi.org/10.1007/BF02760422

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