Abstract
New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.
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Abbreviations
- HOBt:
-
1-hydroxybenzotriazole
- LPO:
-
lipid peroxidation
- MDA:
-
malondialdehyde
- NTB:
-
Nitrotetrazolium Blue
- P-Fe:
-
ferric porphyrinate
- TPP:
-
tetraphenylporphyrin
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Rozhkova, E.A., Lysko, A.I., Kuleshov, K.V. et al. The synthesis and antioxidant activity of azole derivatives of hemin. Russ J Bioorg Chem 26, 419–422 (2000). https://doi.org/10.1007/BF02758671
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DOI: https://doi.org/10.1007/BF02758671