Abstract
To find the incidence of PKU in Iran, 8633 neonates from different hospitals in Tehran were screened. Seven of these neonates had minor hyperphenylalaninemia (5 with 6 mg% and 2 with 8 mg%). Only one case with hyperphenylalaninemia (more than 20 mg%) was detected.
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FoilingA: Ueber Ausscheidung von Pheylbrenztraubens aeure in den Harn als Stoffwechsel anomalie in Verbindung mit Imbezillitaet. Hoppe-Seylers Z Physiol Chem 227: 169, 1934
Kaufman S: A new cofactor required for the enzymatic conversion of phenylalanine to tyrosine. J Biol Chem 230: 931, 1958
Jervis GA: The genetics of Phenylpyruvic oligophrenia. J Ment Sci 85: 719, 1939
Woolf LI, Goodwin BL, Cranstou WI, Wade DN, Woolf F, Hadson FP, and McBean MS: A third allele at the phenylalanine-hydroxylase locus in mild phenylketonuria (hyperphenylalaninemia) Lancet 1: 114, 1968
Lenz W; Medizinische Geneti, 4th Edition, G. Thieme Verlang Stuttgart. P 187, 1979
Witkowski R, Prokop O: Genetik erblicher syndrome and Missbildungen. Akad. Verlag, Berlin. P 262, 1974
Bartholome K: Genetics and Biochemistry of the Phenylketonuria-present state. Hum Genet 51: 241, 1979
Guthrie R, Susi A: A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 32 : 338, 1963
Stevenson JS and Kennedy R: Phenylketonuria Screening in Scotland 1965–1977. GBR-Health Bull (Edinburgh) 36/5:227 1978
Novitski E: Human Genetics. Macmillian Pub Co New York. 1. Edition P 395, 1977
Machill G and Knapp A: On the population genetics of phenylketonuria in the GDR, Humangenetik 31 : 107, 1976
Mekanandha V and Santawanpas S: The gene frequency of Phylketonuria among Thai population-a preliminary report. J Med Assoc Thailand 59 : 359, 1976
Wamberg E: Incidence and distribution of PKU-cases in Denmark. Ir Med J 69 : 395, 1976
Pitt D, Francies I, Wilcken B, Hill G, Masters P, Cusick E, Raby J and McFarlane J: Genetic Screening of the new-born in Australia. Med J Aust 2 : 579, 1977
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Farhud, D.D., Kabiri, M. Incidence of phenylketonuria (PKU) in Iran. Indian J Pediatr 49, 685–688 (1982). https://doi.org/10.1007/BF02752654
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DOI: https://doi.org/10.1007/BF02752654