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The effect of asphyxia on gut blood flow in term neonates

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Abstract

Transcutaneous Doppler ultrasound measurements were made of the superior mesenteric artery of 25 term infants to correlate the intestinal blood flow with neonatal acid-base status as measured in umbilical artery blood and newborn condition as reflected by Apgar score. Compared with the babies whose umbilical artery pH was higher than 7.20 (peak systolic velocity: 84.1 cn/sn, mean velocity 48.6 cm/sn), the blood flow of superior mesenteric artery was significantly decreased in the newborn babies whose umbilical artery pH was less than 7.20 (peak systolic velocity 48.8 cm/sn, mean velocity=32.6 cm/sn). Although no such relationship existed between Apgar scores and superior mesenteric artery blood flow indices, a significant linear correlation between superior mesenteric artery blood flow and umbilical artery pH was noted.

A reduction of intestinal circulation was observed during umbilical cord blood acidemia and hypoxemia.

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References

  1. Hackett GA, Campbell S, Gamsu H, Cohen-Overbeek T, Pearce JMK. Doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, hemorrhage and neonatal morbidity.Br Med. J. 1987; 13: 294.

    Google Scholar 

  2. Deeg KH, Geistner R, Bundacherer F, Harar G, Singer H, Gutheil H. Doppler sonographic detection of reduced flow velocities in the truncus coeliacus in infants with patent ductus arteriosus Botalli in comparison to a healthy control group.Monsschr Kinderheilkd 1987; 135: 24–29.

    CAS  Google Scholar 

  3. Brown JK, Purvis RJ, Forfar JO, Cockloum F. Neurological aspects of perinatal asphyxia.Dev Med Child Neurol 1974; 16: 567–580.

    Article  PubMed  CAS  Google Scholar 

  4. Taylor KJW, Burns PN, Woodcock JP, Wells PNT. Blood flow in deep abdominal and pelvic vessels: ultrasonic pulsed-Doppler analysis.Radiology 1985; 154: 487–493.

    PubMed  CAS  Google Scholar 

  5. Qamar MI, Read AE, Skidmore R, Evans JM, Wells PNT. Transcutaneous Doppler Ultrasound measurement of superior mesenteric artery blood flow in man.Gut 1986; 27: 100–105.

    Article  PubMed  CAS  Google Scholar 

  6. Van Bel F, Van Zuieten PHT, Guit L, Schipper I. Superior Mesenteric Artery blood flow velocity and estimated volume flow. Duplex Doppler US. Study of preterm and term neonates.Pediatr Radiol 1990; 174: 165–169.

    Google Scholar 

  7. Leiding E. Doppler analysis of superior mesnteric artery blood flow in preterm infants.Arch Dis Child. 1989; GI: 476–480.

    Google Scholar 

  8. Kempley ST, Gamou HR, Vyas S, Nicolaides K. Effects of intrauterine growth retardation on postnatal visceral and cerebral blood flow velocity.Arch Dis Child 1991; 66: 1115–1118.

    Article  PubMed  CAS  Google Scholar 

  9. Coombo RC, Morgan Med, Durbin GM, Booth IW, McNeish AS. Gut blood flow velocities in the newborn: effects of patent ductus arterious and parenteral indomethacin.Arch Dis Child 1990; 65: 67–71.

    Google Scholar 

  10. Kempley ST, Gamsu HR. Superior mesenteric artery blood flow velocity in necrositing enterocolitis.Arch Dis Child 1992; 792–796.

  11. Gilstrap LC, Leveno KJ, Burris J, Williams ML, Little BB. Diagnosis of birth asphyxia on the basis of fetal pH, Apgar scores and newborn cerebral dysfunction.Am J Obstet Gynecol 1989; 161: 825–830.

    PubMed  Google Scholar 

  12. Winkler CL, Hault JC, Turker JM, Owen I, Brunfield LG. Neonatal complications at term as term is related to the degree of umbilical artery acidemia.Am J Obstet Gynecol 1991; 164: 637–641.

    PubMed  CAS  Google Scholar 

  13. Szabo JS, Storestreet BS, Olt W. Effects of hypoxemia on gastrointestinal blood flow and gastric emptying in the newborn piglet.Pediatr Res 1985; 19: 446–471.

    Article  Google Scholar 

  14. Yu VYH, Joseph R, Bajukk Bet al. Perinatal risk factors for necrotising enterocolitis.Arch Dis Child 1984; 59: 430–434.

    PubMed  CAS  Google Scholar 

  15. Touloukian RJ, Posch JN, Spencer R. The pathogenesis of ischemic gastroenterocolitis of the neonate: selective gut mucosal ischaemia in asphyxiated neonatal piglets.J Pediatr Surg 1972; 7: 194–205.

    Article  PubMed  CAS  Google Scholar 

  16. Edelstone DF, Holzman F. Gastrointestinal tract O2 uptake and regional blood flows during digestion in conscious newborn lambs.Am J Physiol 1981; G289.

  17. Nowicki PT, Miller RR, Hansen NB, Oh Wet al. Gastrointestinal blood flow and O2 uptake in piglets: recovery from hypoxemia.Pediatr Res 1985; 19: 1197–1200.

    Article  PubMed  CAS  Google Scholar 

  18. Nowicki PT, Hansen NB, Olt Wet al. Gastrointestinal blood flow and oxygen consumption in the newborn lamb: effect of chronic anemia and acute hypoxia.Pediatr Res 1984; 18: 420–425.

    Article  PubMed  CAS  Google Scholar 

  19. Loombo RC, Mongan METF, Durbin GMet al. Doppled assessment of human neonatal gut blood flow velocities: Postnatal adaptation and response to feeds.J Pediatr Gastrointesterol Nutr 1992; 15: 6–12.

    Article  Google Scholar 

  20. Gladman G, Jims DG, Chiswick ML. Gastrointestinal blood flow velocity after the first feed.Arch Dis Child 1991; 66: 17–20.

    PubMed  CAS  Google Scholar 

  21. Szabo JJ, Mayfield SR, Olt W, Stonestreet BJ. Postprandial gastrointestinal blood flow and oxygen consumption: effects of hypoxemia in neonatal piglets.Pediatr Res 1987; 21: 93–98.

    Article  PubMed  CAS  Google Scholar 

  22. Özkan H, Ören H, Erdaĝ N, Çevik N. Breast milk versus infant formulas: effects on intestinal blood flow in neonates.Indian J Pediatr 1994; 61/62: 703–709.

    Article  PubMed  Google Scholar 

  23. Qamar MI, Read AE. Effects of ingestion of carbohydrate, fat, protein and water on mesenteric blood flow in man.Scand J Gastroenterol 1988; 23: 26–30.

    PubMed  CAS  Google Scholar 

  24. Thorp JA, Jampson JE, Parisi VM, Creany RK. Routine umbilical cord blood gas determinations.Am J Obstet Gynecol 1989; 161: 600–605.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Gazi University School of Medicine, Hatir sok 15/2, Gaziosmanpaşa 06700, Ankara, Turkey

    Esin Koç

  2. Ankara University School of Medicine, Hatir sok 15/2, Gaziosmanpaşa 06700, Ankara, Turkey

    Saadet Arsan & Fadil Ertogan

  3. Department of Radiology, Ankara University School of Medicine, Hatir sok 15/2, Gaziosmanpaşa 06700, Ankara, Turkey

    Hasan Özcan & Iihan Erdem

  4. Neonatalogy Unit, Dr. Sami Ulus Children's Hospital, Hatir sok 15/2, Gaziosmanpaşa 06700, Ankara, Turkey

    Ayşegül Zenciroglu

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  1. Esin Koç
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  2. Saadet Arsan
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  4. Ayşegül Zenciroglu
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  5. Iihan Erdem
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  6. Fadil Ertogan
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Koç, E., Arsan, S., Özcan, H. et al. The effect of asphyxia on gut blood flow in term neonates. Indian J Pediatr 65, 297–302 (1998). https://doi.org/10.1007/BF02752307

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