Lipid profile in the progeny of parents with ischemic heart disease

Abstract

Lipid profile of 50 offsprings of parents with ischemic heart disease and 15 control children aged 5–16 years was studied. The children in both the groups were categorized into 3 sub groups, 5–10, 11–15 & >15 years. The Serum total cholesterol levels (mean ±S.D.) (in mg/dl) in the test group were 169.8±15.13, 173.34±33.56, 177.4±27.89 respectively for the 3 age subgroups. The Serum LDL cholesterol levels (mean ±S.D) (in mg/dl) in the test group were 102.2±15.25, 95.13±30.38, 101.09±26.96 respectively. The serum total cholesterol levels (mean ±S.D) (in mg/dl) in the control group were 123±1.33, 118±7.51 and 127.4±5.77 respectively for the 3 age subgroups. The serum LDL cholesterol levels (mean +S.D) (in mg/dl) in the control group were 56.64±8.75, 43.36±6.10 and 45.16±6.78 respectively. The serum total cholesterol and LDL cholesterol levels in the test group were significantly higher as compared to controls (p>0.05). Among test subjects, 54% had elevated total cholesterol (>170 mg/dl) and 38% had elevated LDL cholesterol (>110 mg/dl). These cases had a significant correlation with elevated parental total cholesterol and LDL cholesterol levels (p>0.05). Thus, a selective screening of the offsprings of parents with premature ischemic heart disease and hypercholesterolemia is advocated.