Skip to main content
SpringerLink
Log in

Re-operations of supratentorial anaplastic astrocytomas

  • Clinical Articles
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

Results of re-operations of 99 adult patients with recurrent supratentorial lobar glioblastomas (60 patients) and anaplastic astrocytomas (39 patients) have been reviewed. In all cases both surgical interventions were performed at the same institute. Age of patients with glioblastoma varied between 19 and 64 and with anaplastic astrocytoma between 21 and 68 years, with a mean value of 48 and 36 years, respectively. The median interval between the first and second operations was 47 weeks for patients with glioblastoma and 83 weeks with anaplastic astrocytoma. The mortality rate of the re-operations was 3%. Following re-operation radio-and/or chemotherapy was applied in most of the cases. Median survival time after re-operation was 18.5 weeks in patients with glioblastoma and 55 weeks with anaplastic astrocytoma. Survival curves were calculated according to Kaplan-Meier method and for statistical evaluation the generalized Wilcoxon test and multiple linear regression method were used.

Histologically lower grade tumour at the first operation and longer interval between the two operations proved to influence positively and differentiation of the primary tumour negatively the survival time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Áfra D, Müller W, Benoist G, Schröder R (1978) Supratentorial recurrences of gliomas. Results of reoperation on astrocytomas and oligodendrogliomas. Acta Neurochir (Wien) 43: 217–227

    Article  Google Scholar 

  2. Áfra D, Norman D, Levin VA (1980) Cysts in malignant gliomas: identification by computerized tomography. J Neurosurg 43: 821–825

    Google Scholar 

  3. Áfra D (1982) Treatment of supratentorial glioma recurrencies with reoperation and chemotherapy. In: Brock M (ed) Modern neurosurgery, 1. Springer, Berlin Heidelberg New York, pp 137–143

    Google Scholar 

  4. Áfra D, Müller W (1991) Recurrent low-grade gliomas: dedifferentiation and prospects of reoperation. In: Karim ABMF, Laws ER, Jr (eds) Glioma. Principles and practice in neurooncology. Springer, Berlin Heidelberg New York Tokyo, pp 189–204

    Google Scholar 

  5. Ammirati M, Galicich JH, Arbit E, Liao Y (1987) Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 21: 607–613

    PubMed  CAS  Google Scholar 

  6. Berger MS, Tucker A, Spence A, Winn HR (1992) Reoperation for glioma. Clin Neurosurg 39: 172–186

    PubMed  CAS  Google Scholar 

  7. Finkmeyer H, Kramer W, Pfingst E, Tzonos T (1965) Malignität und Rezidiv bei hirneigenen Tumoren. Zbl Neurochir 25: 281–299

    Google Scholar 

  8. Fusek I, Vorreith M (1976) Indikationen zur Reoperation von Hirngliomen. Zbl Neurochir 37: 45–50

    CAS  Google Scholar 

  9. Gehan EA (1965) A generalized Wilcoxon test for comparing arbitrarily singly censorod samples. Biometrika 52: 203–222

    PubMed  CAS  Google Scholar 

  10. Harsh IV GR, Levin VA, Gutin PhH, Seager M, Silver BA, Wilson ChB (1987) Reoperation for recurrent glioblastoma and anaplastic astrocytoma. Neurosurgery 21: 615–621

    Article  PubMed  Google Scholar 

  11. Kaplan EM, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Statist Assoc 53: 457–481

    Article  Google Scholar 

  12. Kleihues P, Burger PC, Scheithauer BW (1993) World Health Organization. International histological classification of tumours. Histological typing of tumours of the central nervous system, 2nd Ed. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  13. Lorenz R (1967) Zur Frage der Rezidivoperationen bei Gliomen. Zbl Neurochir 28: 27–34

    CAS  Google Scholar 

  14. Moser RP (1988) Surgery for glioma relapse. Factors that influence a favorable outcome. Cancer 62: 381–390

    Article  PubMed  CAS  Google Scholar 

  15. Pool JL (1969) The management of recurrent gliomas. Clin Neurosurg 15: 265–287

    Google Scholar 

  16. Ransohoff J, Lieberman AN (1978) Surgical treatment of primary malignant brain tumour. Clin Neurosurg 25: 403–411

    PubMed  CAS  Google Scholar 

  17. Ray S (1964) Surgery of recurrent intracranial tumours. Clin Neurosurg 10: 1–30

    PubMed  CAS  Google Scholar 

  18. Rostomily RC, Spence AM, Duong D, McCormick K, Bland M, Berger MS (1994) Multimodality management of recurrent adult malignant gliomas: results of a phase II multiagent chemotherapy study and analysis of cytoreductive surgery. Neurosurgery 35: 378–388

    Article  PubMed  CAS  Google Scholar 

  19. Rubinstein LJ (1972) Tumours of the central nervous system. Atlas of tumour pathology, Second series, Fascicle 6. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  20. Salcman M, Kaplan RS, Ducker TB, Abdo H, Montgomery E (1982) Effect of age and reoperation on survival in the combined modality treatment of malignant astrocytoma. Neurosurgery 10: 454–463

    Article  PubMed  CAS  Google Scholar 

  21. Salcman M, Scholtz H, Kaplan RS, Kulik S (1994) Long-term survival in patients with malignant astrocytoma. Neurosurgery 34: 213–220

    Article  PubMed  CAS  Google Scholar 

  22. Vick NA, Ciric IS, Eller TW, Cozzens JW, Walsh A (1989) Reoperation for malignant astrocytoma. Neurology 39: 430–432

    PubMed  CAS  Google Scholar 

  23. Wallner KE, Galicich JH, Krol G, Arbit E, Malkin MG (1989) Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Oncol Biol Phys 16: 1405–1409

    PubMed  CAS  Google Scholar 

  24. Wallner KE, Galicich JH, Malkin MG, Arbit E, Krol G, Rosenblum MK (1989) Inability of computed tomography appearance of recurrent malignant astrocytoma to predict survival following reoperation. J Clin Oncol 7: 1492–1496

    PubMed  CAS  Google Scholar 

  25. Wigner MJ, MacDonald DR, Cairncross JG (1989) Supratentorial anaplastic gliomas in adults. J Neurosurg 71: 487–493

    Google Scholar 

  26. Young B, Oldfield EH, Markesberry WR, Haack D, Tibbs PA, McCombs P, Chin HW, Maruyama Y, Meacham WF (1981) Reoperation for glioblastoma. J Neurosurg 55: 917–921

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Neurosurgery, Amerikai út 57, H-1145, Budapest, Hungary

    L. Sipos & D. Áfra

Authors
  1. L. Sipos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Áfra
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sipos, L., Áfra, D. Re-operations of supratentorial anaplastic astrocytomas. Acta neurochir 139, 99–104 (1997). https://doi.org/10.1007/BF02747187

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02747187

Keywords

Search

Navigation