Abstract
We report a case of unilateral primary adrenal cortical hyperplasia associated with hyperaldosteronism in a 39-yr-old Chinese man. The patient presented with hypertension, hypokalemia, primary hyperaldosteronism, suppressed renin activity, and was complicated with aortic dissection. The aortic dissection required emergency realignment while unilateral laparoscopic adrenalectomy was performed subsequently. Pathologic examination of the adrenal lesion revealed multiple cortical nodules (up to 1.4 cm in diameter). No telomerase activity was detected in the adrenal lesion. A review of the literature showed that unilateral adrenal cortical hyperplasia has a predilection for the left side occurring more often in males. We conclude that unilateral adrenal cortical hyperplasia is a rare but unique entity and that unilateral adrenalectomy is the treatment of choice.
Similar content being viewed by others
References
Lam KY. Adrenal tumors in Chinese. Virchows Arch A 421:13–16, 1992.
Lo CY, Tam PC, Kung AWC, Lam KSL, Wong J. Primary aldosteronism: results of surgical treatment. Ann Surg 224:125–130, 1996.
Ross EJ. Conn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomy. Am J Med 39:994–1002, 1965.
Weinberger MH, Grim CE, Hollifield JW, Kem DC, Ganguly A, Kramer NJ, et al. Primary aldosteronism: diagnosis, localization, and treatment. Ann Intern Med 90:386–395, 1979.
Ganguly A, Zager PG, Luetscher JA. Primary aldosteronism due to unilateral adrenal hyperplasia. J Clin Endocrinol Metab 51:1190–1194, 1980.
Mendlowitz M. A case of predominantly unilateral pseudoprimary hyperaldosteronism. Mt Sinai J Med 49:76–77, 1982.
Ganguly A, Yum MN, Pratt JH, Weinberger MH, Grim CE, Yune HY, et al. Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Clin Exp Hypertens A 5:635–658, 1983.
Oberfield SE, Levine LS, Firpo A, Lawrence D Sr, Stoner E, Levy DJ, et al. Primary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia: case report. Hypertension 6:75–84, 1984.
Kem DC, Tang K, Hanson CS, Brown RD, Painton R, Weinberger MH, et al. The prediction of anatomical morphology of primary aldosteronism using serum 18-hydroxycorticosterone levels. J Clin Endocrinol Metab 60:67–73, 1985.
Lim RC Jr, Nakayama DK, Biglieri EG, Schambelan M, Hunt TK. Primary aldosteronism: changing concepts in diagnosis and management. Am J Surg 152:116–121, 1986.
Dye NV, Litton NJ, Varma M, Isley WL. Unilateral adrenal hyperplasia as a cause of primary aldosteronism. South Med J 82:82–86, 1989.
Sasagawa I, Nakada T, Hashimoto T, Kato T, Suzuki H, Ishigooka M, et al. Unilateral diffuse adrenal hyperplasia masquerading as aldosterone-producing adenoma in primary hyperaldosteronism. Urol Int 50:218–222, 1993.
Pignatelli D, Falcao H, Coimbra-Peixoto A, Cruz F. Unilateral adrenal hyperplasia. South Med J 87:664–667, 1994.
Edwards CRW. Primary mineralcorticoid excess syndrome. In: DeGroot LJ, Besser M, Burger HG, Jameson JL, Loriaux DL, Marsahall JC, Odell WD, Potts JT Jr, Rubenstein AH, eds. Endocrinology, 3rd ed. Philaldelphia: WB Saunders, 1775–1803, 1995.
Abdelhamid S, Muller-Lobeck H, Pahl S, Remberger K, Bonhof JA, Walb D, et al. Prevalence of adrenal and extra-adrenal Conn syndrome in hypertensive patients. Arch Intern Med 156:1190–1195, 1996.
Chen LG, Lee TI, Lin HD, Wang HC, Liu WY, Tang KT. Primary aldosteronism due to unilateral adrenal hyperplasia: a case report. Chin Med J Taipei 59:114–120, 1997.
Siren J, Valimaki M, Huikuri K, Sivula A, Voutilainen P, Haapiainen R Adrenalectomy for primary aldosteronism: long-term follow-up study in 29 patients. World J Surg 22:418–21, 1998.
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015, 1994.
Lam AKY, Chan ACL. Aortic aneurysm at autopsy: a five year survey in Hong Kong. Am J Cardiovasc Pathol 4:31–40, 1992.
Winfield HN, Hamilton BD, Bravo EL, Novick AC, Laparoscopic adrenalectomy: the preferred choice? A comparison to open adrenalectomy. J Urol 160:325–329, 1998.
Ting AC, Lo CY, Lo CM. Posterior or laparoscopic approach for adrenalectomy. Am J Surg 175:488–490, 1998.
Gasman D, Droupy S, Koutani A, Salomon L, Antiphon P, Chassagnon J, et al. Laparoscopic adrenalectomy: the retroperitoneal approach. J Urol 159:1816–1820, 1998.
Heniford BT, Iannitti DA, Hale J, Gagner M. The role of intraoperative ultrasonography during laparoscopic adrenalectomy. Surgery 1997;1068–1073, 1997.
Mercan S, Seven R, Ozarmagan S, Tezelman S. Endoscopic retroperitoneal adrenalectomy. Surgery 118:1071–1075, 1995.
Soria JC, Vielh P, El-Naggar AK. Telomerase activity in cancer: a magic bullet or a mirage? Adv Anat Pathol 5:86–94, 1998.
Autexier C, Greider CW. Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci 21:387–391, 1996.
Cheng AJ, Lin JD, Chang T, Wang TC. Telomerase activity in benign and malignant human thyroid tissues. Br J Cancer 77:2177–2180, 1998.
Saito T, Schneider A, Martel N, Mizumoto H, Bulgay-Moerschel M, Kudo R, et al. Proliferation-associated regulation of relomerase activity in human endometrium and its potential implication in early cancer diagnosis. Biochem Biophys Res Commun 231:610–614, 1997.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lam, KY., Lo, CY. The clinicopathologic significance of unilateral adrenal cortical hyperplasia: Report of an unusual case and a review of the literature. Endocr Pathol 10, 243–249 (1999). https://doi.org/10.1007/BF02738886
Issue Date:
DOI: https://doi.org/10.1007/BF02738886