Skip to main content
SpringerLink
Log in

Minimally invasive follicular carcinoma

  • Clinical Research
  • Published:
Endocrine Pathology Aims and scope Submit manuscript

Abstract

The criteria for the diagnosis of follicular carcinoma of the thyroid and in particular of the “minimally invasive” variant are discussed. The introduction of a new terminology reflecting the indolent behavior of most of the thyroid neoplasms morphologically resembling follicular adenomas, and currently diagnosed as carcinomas on the sole basis of capsular invasion, is recommended.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chen KTK, Rosai J. Follicular variant of papillary carcinoma: a clinicopathologic study of six cases. Am J Surg Pathol 1:123–130, 1977.

    Google Scholar 

  2. Rosai J, Zampi G, Carcangiu ML. Papillary carcinoma of the thyroid. Am J Surg Pathol 7:809–817, 1983.

    PubMed  CAS  Google Scholar 

  3. Carcangiu ML, Zampi G, Rosai J. Papillary thyroid carcinoma: a study of its many morphologic expression and clinical correlates. Pathol Annu 20:1–43, 1985.

    PubMed  Google Scholar 

  4. Sakamoto A, Kasai N, Sugano H. Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas. Cancer 52:1849–1855, 1983.

    Article  PubMed  CAS  Google Scholar 

  5. Carcangiu ML, Zampi G, Rosai J. Poorly differentiated (insular) thyroid carcinoma. A reinterpretation of Langhans' “wuchernde Struma.” Am J Surg Pathol 8:655–668, 1984.

    Article  PubMed  CAS  Google Scholar 

  6. Papotti M, Botto-Micca F, Favero A, Palestini N, Bussolati G. Poorly differentiated thyroid carcinomas with primordial cell component: a group of aggressive lesions sharing insular, trabecular and solid patterns. Am J Surg Pathol 17:291–301, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Sobrinho-Simoes M. Poorly differentiated carcinoma of the thyroid. Endocrine Pathol 7:99–102, 1996.

    Google Scholar 

  8. Carcangiu ML, Zampi G, Pupi A, Castagnoli A, Rosai J. Papillary carcinoma of the thyroid. A clinico-pathologic study of 241 cases treated at the University of Florence, Italy. Cancer 55:805–828, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. LiVolsi VA, Asa SL. The demise of follicular carcinoma of the thyroid gland. Thyroid 4:233, 1994.

    Article  PubMed  CAS  Google Scholar 

  10. Hedinger CE, Williams ED, Sobin LH. Histological typing of thyroid tumors. In: Hedinger CE, ed. International histological classification of tumours. vol 11. Berlin: Springer-Verlag, 1988; 7, 8.

    Google Scholar 

  11. Meissner W, Warren S. Tumors of the Thyroid Gland. Atlas of Tumor Pathology, 2nd ser., fascicle 3. Washington, DC, Armed forces Institute of Pathology, 1969.

    Google Scholar 

  12. Harness JK, Thompson NW, McLeod MK, Eckhauser FE, Lloyd RV. Follicular carcinoma of the thyroid gland: trends and treatment. Surgery 96:972–980, 1984.

    PubMed  CAS  Google Scholar 

  13. Carcangiu ML, Bianchi S, Savino D, Voynick IM, Rosai J. Follicular Hurthle cell tumors of the thyroid gland. Cancer 68:1944–1953, 1991.

    Article  PubMed  CAS  Google Scholar 

  14. Franssila KO, Ackerman LV, Brown CL, Hedinger CE. Follicular carcinoma. Semin Diagn Pathol 2:101–122, 1985.

    PubMed  CAS  Google Scholar 

  15. Yamashina M. Follicular neoplasms of the thyroid. Total circumferential evaluation of the fibrous capsule. Am J Surg Pathol 16:392–400, 1992.

    Article  PubMed  CAS  Google Scholar 

  16. Evans HL. Follicular neoplasms of the thyroid. A study of 44 cases followed for a minimum of 10 years, with emphasis on differential diagnosis. Cancer 54:535–540, 1984.

    Article  PubMed  CAS  Google Scholar 

  17. Kahn NF, Perzin KH. Follicular carcinoma of the thyroid: an evaluation of the histologic criteria used for diagnosis. Pathol Annu 18:221–253, 1983.

    PubMed  Google Scholar 

  18. Rosai J, Carcangiu ML, DeLellis RA. Tumors of the Thyroid Gland. Atlas of Tumor Pathology, 3rd ser., Fascicle 5, Washington, DC, Armed Forces Institute of Pathology, 1993.

    Google Scholar 

  19. Harach HR, Jasani B, Williams ED. Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid. J Clin Pathol 36:1050–1054, 1983.

    Article  PubMed  CAS  Google Scholar 

  20. Stephenson TJ, Griffiths DW, Mills PM. Comparison of Ulex europaeus I lectin binding and factor VIII-related antigen as markers of vascular endothelium in follicular carcinoma of the thyroid. Histopathology 10:251–260, 1986.

    Article  PubMed  CAS  Google Scholar 

  21. Young RL, Mazzaferri EL, Rahe AJ, Dorfman SG. Pure follicular thyroid carcinoma: impact of therapy in 214 patients. J Nucl Med 21:733–737, 1980.

    PubMed  CAS  Google Scholar 

  22. Schröder S, Pfannschmidt N, Dralle H, Arps H, Böcker W. The encapsulated follicular carcinoma of the thyroid. Virchows Arch [Pathol Anat] 402:259–273, 1984.

    Article  Google Scholar 

  23. Brennan MD, Bergstralh EJ, van Heerden JA, McConahey WM. Follicular thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy, and outcome. Mayo Clin Proc 66:11–22, 1991.

    PubMed  CAS  Google Scholar 

  24. Clark OH. Total thyroidectomy: the treatment of choice for patients with differentiated thyroid cancer. Ann Surg 196:361–370, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Woolner LB, Beahrs OH, Black BM, McConahey WM, Keating FR Jr. Classification and prognosis of thyroid carcinoma. Am J Surg 102:354–387, 1961.

    Article  PubMed  CAS  Google Scholar 

  26. Lang W, Choritz H, Hundeshagen H. Risk factors in follicular thyroid carcinoma. A retrospective follow-up study covering a 14-year period with emphasis on morphological findings. Am J Surg Pathol 10:246–255, 1986.

    Article  PubMed  CAS  Google Scholar 

  27. Schmidt RJ, Wang C. Encapsulated follicular carcinoma of the thyroid: diagnosis, treatment, and results. Surgery 100:1068–1075, 1986.

    PubMed  CAS  Google Scholar 

  28. Iida F. Surgical significance of capsule invasion of adenoma of the thyroid. Surg Gynecol Obstet 144:710–712, 1977.

    PubMed  CAS  Google Scholar 

  29. Cady B, Rossi R, Silverman M, Wool M. Further evidence of the validity of risk group definition in differentiated thyroid carcinoma. Surgery 98:1171–1178, 1985.

    PubMed  CAS  Google Scholar 

  30. van Heerden JA, Hay ID, Goellner JR, Salomao D, Ebersold JR, Bergstralh EJ, Grant CS. Follicular thyroid carcinoma with capsular invasion alone: a nonthreatening malignancy. Surgery 112:1130–1138, 1992.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, PO Box 208070, 06520-8070, New Haven, CT

    Maria L. Carcangiu MD

Authors
  1. Maria L. Carcangiu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carcangiu, M.L. Minimally invasive follicular carcinoma. Endocr Pathol 8, 231–234 (1997). https://doi.org/10.1007/BF02738790

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02738790

Key Words

Search

Navigation