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Insulin requirement of simple and complex carbohydrate foods in type 1 (insulin-dependent) CSII-treated diabetic subjects, obtained by Biostator. Correlation with glycaemic index

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The aim of this work was to observe whether different types of carbohydrates might require different insulin doses. Five type 1 CSII-treated diabetic subjects (age 39±4 years), C-peptide negative and in optimal metabolic control (HbA1c 7.5±0.2) were selected for the study. They were connected to the Biostator 6 times with an interval of 4–10 days between sessions and fed a meal containing 75 g of carbohydrates of different types: bread, pasta, potatoes, apples, oranges and sucrose. The following net (above basal) insulin requirement for the 30 meals were found (IU-mean+SD): bread 9.15±1.97; pasta 6.00±1.37; potatoes 7.05±2.58; apples 4.54±1.42; oranges 6.21±2.62; sucrose 7.83±2.33. A statistically significant difference was found by ANOVA among insulin requirements for foods (p<0.05). Single comparisons between bread and the other foods showed a statistically significant difference only between bread and apple (p<0.05). Mean coefficient of variation was 33.9% for the subjects and 30.7% for the meals. A significant correlation was found between Jenkins’ glycaemic index and insulin requirement (r=0.897; p<0.001). In conclusion, the high intraindividual variability of insulin requirement does not advice the use of the glycaemic index during optimized insulin therapy.

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Authors and Affiliations

  1. Istituto di Medicina Interna, Università degli Studi di Chieti, Piazza Mons. Venturi, 30, 66100, Chieti, Italy

    Fabio Capani, Giuseppe Casalini, Agostino Consoli, Agostino D’Emilio, Gianfranco La Nave, Mariarosa Loragno, Ester Vitacolonna & Giuseppe Zappone

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  1. Fabio Capani
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  2. Giuseppe Casalini
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  3. Agostino Consoli
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  4. Agostino D’Emilio
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  5. Gianfranco La Nave
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  6. Mariarosa Loragno
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  7. Ester Vitacolonna
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  8. Giuseppe Zappone
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Capani, F., Casalini, G., Consoli, A. et al. Insulin requirement of simple and complex carbohydrate foods in type 1 (insulin-dependent) CSII-treated diabetic subjects, obtained by Biostator. Correlation with glycaemic index. Acta diabet. lat 28, 47–53 (1991). https://doi.org/10.1007/BF02732113

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  • DOI: https://doi.org/10.1007/BF02732113

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