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Lipid peroxidation in bronchial asthma

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Abstract

Objective: To study the levels of free oxygen radicals in children with bronchial asthma during an attack and symptom free interval.Methods: Serum Malondiadehyde (MDA) levels were studied in 25 children between the age of 6 years-14 years who presented with an acute attack of bronchial asthma. In each patient, serum MDA levels were measured at the time of admission, 24–48 hours after good response to treatment and after a symptom free interval of 3 weeks. Results were compared with control group.Results: In study group serum MDA levels were highest at the time of admission, which decreased significantly at 24–48 hours with treatment. After a 3 weeks symptom free interval serum MDA levels had decreased further but were still higher than healthy control group.Conclusion: Lipid peroxidation is increased in bronchial asthma during an acute attack and symptom free period.

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References

  1. Sedgwick JB, Geiger KM, Busse WW. Superoxide generation by hypodense eosinophils from patients with asthma.Am Rev Respir Dis 1990; 142:120–125.

    PubMed  CAS  Google Scholar 

  2. Zakharian AK, Amatuni VG. The interconnection of changes in the levels of prostaglandins, catecholamines and lipid peroxidation of membrane lipids in patients with bronchial asthma.Vopr Med Khim 1991; 37(3): 45–47.

    PubMed  CAS  Google Scholar 

  3. Neijens HJ, Raatgeep RE, Dejenhart HJ, Duiverman EJ, Kerrebijan KF. Altered leukocyte response in relation to the basic abnormality in children with asthma and bronchial hyper responsiveness.Am Rev Respir Dis 1984; 130: 744–747.

    PubMed  CAS  Google Scholar 

  4. Chanez P, Dent G, Yukawa T, Barnes PJ, Chung KF. Generatio of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester.Eur Respir /1990; 3:1002–1007.

    CAS  Google Scholar 

  5. Cross CE, Halliwell B. Biological consequences of general environmental contaminants. In Crystal RG, West JB, eds.The Lung Scientific Foundations. New York; Raven Press, 1991; 1875–1980.

    Google Scholar 

  6. Parson PE, Warthen GS, Henson PM. Injury from inflammatory cells. In Crystals RG, West JB, eds.The Lung Scientific Foundation. New York; Raven Press, 1991; 1981–1992.

    Google Scholar 

  7. Crystal RG. Oxidant and respiratory tract epithelial injury: Pathogenesis and strategies for therapeutic intervention.Am J Med 1991; 91 (Suppl 36): 39–44.

    Article  Google Scholar 

  8. The International Study of Asthma-Allerges in childhood (ISAAC) Steering Committee. World wide variatio in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema; ISAAC.Lancet 1998; 351:1225–1232.

    Article  Google Scholar 

  9. Chesseman KH. Mechanism and effects of lipid peroxidation.Molec Aspects Med 1993; 14:191–197.

    Article  Google Scholar 

  10. Babior BM. The respiratory burst of phagocytes.J Clin Invest 1984; 73:599–601.

    Article  PubMed  CAS  Google Scholar 

  11. Meneely GR, Renzetti AD, Steek JD, Wyatt JP, Harsis HW. American Thoracic Society.Thorax 1960; 15 (132): 762–768.

    Google Scholar 

  12. Placer ZA, Cushmann LL, Johnson BC. Estimation of production of lipid peroxidation (malondialdehyde) in biochemical assay.Anal Biochemistry 1966; 16:359–364.

    Article  CAS  Google Scholar 

  13. Vachier I, Damon M, Doucen CLet al. Increased oxygen species generation in blood monocytes of asthmatic patients.Am Rev Respir Dis 1992; 146:1161–1166.

    PubMed  CAS  Google Scholar 

  14. Ouzel M, Damon M, Chanez Pet al. Enhanced alveolar cell luminol-dependent Chemiluminescence in asthma.J Allergy Clin Immunol 1987; 80:195–201.

    Article  Google Scholar 

  15. Chanez P, Dent G, Yukawa T, Barnes PJ, Chung KF. Generation of oxygen free radicals from blood eosinophils from asthma patients after stimullation with PAF or phorbol ester.Eur Respir J 1990; 3:1002–1007.

    PubMed  CAS  Google Scholar 

  16. Kanazawa H, Kurihara N, Hirata K, Takeda T. The role of free radicals in airways obstruction in asthmatic children.Chest 1991; 100:1319–1322.

    PubMed  CAS  Google Scholar 

  17. Novak Z, Nemeth I, Gyurkovits K, Varga SI, Matkovics B. Examination of the role of oxygen free radicals in bronchial asthma in childhood.Clinical Chemica Acta 1991; 201:247–252.

    Article  CAS  Google Scholar 

  18. Boljevic S, Daniljak IG, Kogan AH. Changes in free radicals and possibility of their correction in patients with bronchial asthma.Vojnosanit Pregl 1993; 50(1): 3–18.

    PubMed  CAS  Google Scholar 

  19. Daniliak IG, Koagan AH, Bolevich S. The generation of active forms of oxygen by the blood leukocytes, lipid peroxidation and antiperoxide protection in bronchial asthma patients.Ter Arkh 1992; 64:54–57.

    PubMed  CAS  Google Scholar 

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  1. Anita Sharma

    Present address: Department of Pediatrics, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

Authors and Affiliations

  1. Department of Biochemistry, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

    R. K. Nagpal

  2. Department of Pediatrics, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

    Satish Bansal & R. K. Nagpal

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  1. Anita Sharma
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  2. Satish Bansal
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Correspondence to Anita Sharma.

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Sharma, A., Bansal, S. & Nagpal, R.K. Lipid peroxidation in bronchial asthma. Indian J Pediatr 70, 715–717 (2003). https://doi.org/10.1007/BF02724313

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