Abstract
Treatment with bovine surfactant (SF-RI 1) was shown to be efficacious in improving pulmonary function and in increasing survival rate without BPD in very premature infants. Surfactant therapy did not affect the risk of major complications of prematurity.
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Hallman M, Merritt TA, Jarvenpaa AL, Boynton B, Mannino F, Gluck L, Moore T, Edwards D (1985) Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective clinical trial. J Pediatr 106:963–969
Merritt TA, Hallman M, Bloom BT, Berry C, Benirschke K, Sahn D, Key T, Edwards D, Jarvenpaa AL, Pohjavuori M, Kankaanpaa K, Kunnas M, Paatero H, Rapola J, Jaaskelainen J (1986) Prophylactic treatment of very premature infants with human surfactant. N Engl J Med 315:785–790
Enhorning G, Shennan A, Possmayer F, Dunn M, Chen CP, Milligan J (1985) Prevention of neonatal respiratory distress syndrome by tracheal installation of surfactant: a randomized clinical trial. Pediatrics 76:145–153
Kwong MS, Egan EA, Notter RH, Shapiro DL (1985) Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants. Pediatrics 76:585–592
Gitlin JD, Soll RF, Parad RB, Horbar JD, Feldmann HA, Lucey JF, Taeusch HW (1987) Randomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease. Pediatrics 79:31–37
Raju TNK, Vidyasagar D, Bhat R, Sobel D, McCulloch KM, Anderson M, Maeta H, Levy PS, Furner S (1987) Double-blind controlled trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease. Lancet I:651–656
Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL, Sinkin RA, Wood BP, Shapiro DL (1988) Surfactant replacement therapy at birth: Final analysis of a clinical trial and comparisons with similar trials. Pediatrics 82:756–762
Horbar JD, Soll RF, Sutherland JM, Kotagal U, Philip AGS, Kessler DL, Little GA, Edwards WH, Vidyasagar D, Raju TNK, Jobe AH, Ikegami M, Mullett MD, Myerberg DZ, McAufliffe TL, Lucey JF (1989) A multicenter randomized, placebo-controlled trial of surfactant therapy for respiratory distress syndrome. N Engl J Med 320:959–965
Collaborative European Multicenter Study Group (1988) Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Pediatrics 82:683–691
Merritt TA, Hallman M (1988) Surfactant replacement. A new era with many challenges for neonatal medicine. Am J Dis Child 142:1333–1339
Disse B, Gortner L, Weller E, Eberhardt H, Ziegler H (1988) Efficacy and standardisation of SF-RI 1: a preparation from bovine lung surfactant. In: Lachmann B, ed. Surfactant replacement therapy in neonatal and adult respiratory distress syndrome. Berlin, Heidelberg, New York: Springer-Verlag, pp 37–41
Gortner L, Pohlandt F, Disse B, Weller E (in press) Effects of tracheal instillation of bovine surfactant (SF-RI 1) in premature lambs. Eur J Pediatr
Gortner L, Pohlandt F, Bartmann P, Disse B (1990) Die Behandlung des Atemnotsyndroms (RDS) sehr kleiner Frühgeborener mit natürlichem Surfactant. Monatsschr Kinderheilk 138:8–12
Toce SS, Farrell PM, Leavitt LA, Samuels DP, Edwards DK (1984) Clinical and roentgenographic scoring systems for assessing bronchopulmonary dysplasia. Am J Dis Child 138:581–585
Jobe A, Ikegami M (1987) Surfactant for the treatment of respiratory distress syndrome. Am Rev Respir Dis 136:1256–1275
Heicher DA, Kasting DS, Harrod JR (1981) Prospective clinical comparison of two methods for mechanical ventilation of neonates. Rapid rate and short inspiratory time versus slow rate and long inspiratory time. J Pediatr 98:957–961
Shankaran S, Slovis TL, Bedard MP, Poland RL (1982) Sonographic classification of intracranial hemorrhage. A prognostic indicator of mortality, morbidity, and short-term neurologic outcome. J Pediatr 100:469–475
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Gortner, L., Bernsau, U., Hellwege, H.H. et al. A multicenter randomized controlled clinical trial of bovine surfactant for prevention of respiratory distress syndrome. Lung 168 (Suppl 1), 864–869 (1990). https://doi.org/10.1007/BF02718221
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DOI: https://doi.org/10.1007/BF02718221