Skip to main content
Log in

Neopterin as an index of immune response in patients with tuberculosis

  • Original Articles
  • Published:
Lung Aims and scope Submit manuscript

Abstract

Urinary neopterin levels were measured by high-performance liquid chromatography in 55 patients with pulmonary tuberculosis. A positive correlation between mean neopterin levels, extent and activity of disease was apparent. Neopterin levels reflect changes of disease course earlier than other currently available procedures. Neopterin levels are valuable for the management of pulmonary tuberculosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bichler A, Fuchs D, Hausen A, Hetzel H, Reibnegger G, Wachter H (1983) Measurement of urinary neopterin in normal, pregnant and non-pregnant women and in women with benign and malignant genital tract neoplasms. Arch Gynecol 233:121–130

    Article  PubMed  CAS  Google Scholar 

  2. Clot J, Charmasson E, Brochier J (1972) Age-dependent changes of human blood lymphocyte subpopulations. Clin Exp Immunol 32:346–351

    Google Scholar 

  3. Collins FM (1982) The immunology of tuberculosis. Am Rev Respir Dis 125:42–49

    PubMed  CAS  Google Scholar 

  4. El-Naggar AK, Higaschi GJ (1982) In vivo and in vitro cell mediated immunity in tuberculosis meningitis. J Clin Lab Immunol 8:37–42

    PubMed  CAS  Google Scholar 

  5. Forschback G (1982) Die postprimäre pulmonale Tuberkulose. In: Hein J, Ferlinz R (eds) Lungentuberkulose. Thieme, Stuttgart New York, pp 4.1–4.104

    Google Scholar 

  6. Fuchs D, Hausen A, Huber Ch, Margreiter R, Reibnegger G, Spielberger M, Wachter H (1982) Pteridine secretion as marker for the proliferation of allo-antigen-induced lymphocytes. Hoppe-Seyler’s Z Physiol Chem 363:661–664

    PubMed  CAS  Google Scholar 

  7. Fuchs D, Hausen A, Reibnegger G, Wachter H (1982) Automatized routine estimation of neopterin in human urine by HPLC on reversed phase. In: Wachter H, Curtius HCh, Pfleiderer W (eds) Biochemical and clinical aspects of pteridines. de Gruyter, Berlin New York, pp 67–79

    Google Scholar 

  8. Goldstein RA, Ang UH, Foellmer JW, Janicki BW (1976) Rifampicin and cell-mediated immune responses in tuberculosis. Am Rev Respir Dis 113:197–202

    PubMed  CAS  Google Scholar 

  9. Hausen A, Fuchs D, Wachter H (1981) Determination of creatinine in urine by high performance liquid chromatography (HPLC). J Clin Chem Clin Biochem 19:365–378

    Google Scholar 

  10. Hausen A, Fuchs D, Grünewald K, Huber H, König K, Wachter H (1981) Urinary neopterin as marker for haematological neoplasias. Clin Chim Acta 117:297–305

    Article  PubMed  CAS  Google Scholar 

  11. Hausen A, Fuchs D, König K, Wachter H (1982) Determination of neopterin in human urine by reversed phase high performance liquid chromatography. J Chromatogr 227:61–70

    Article  PubMed  CAS  Google Scholar 

  12. Hausen A, Fuchs D, Grünewald K, Huber H, König K, Wachter H (1982) Urinary neopterin in the assessment of lymphoid and myeloid neoplasia, and neopterin levels in haemolytic anaemia and benign monoclonal gammopathy. Clin Biochem 15:34–37

    Article  PubMed  CAS  Google Scholar 

  13. Hausen A, Wachter H (1982) Pteridines in the assessment of neoplasia. J Clin Chem Clin Biochem 20:593–602

    PubMed  CAS  Google Scholar 

  14. Huber Ch, Fuchs D, Hausen A, Margreiter R, Reibnegger G, Spielberger M, Wachter H (1983) Pteridines as a new marker to detect human T-cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. J Immunol 130:1047–1050

    PubMed  CAS  Google Scholar 

  15. Huber Ch, Batchelor R, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J, Wachter H (1984) Immune response associated production of neopterin: release from macrophages primarily under control of interferon-gamma. J Exp Med 160:310–316

    Article  PubMed  CAS  Google Scholar 

  16. Joffe MJ, Rabson AR (1981) Suppression of LIF production but not blastogenesis in patients with tuberculosis meningitis. Clin Immunol Immunopathol 18:245–253

    Article  PubMed  CAS  Google Scholar 

  17. Kostron-Krainz Ch, Fuchs D, Hausen A, Reibnegger G, Wachter H (1982) Urinary neopterin evaluation in malignant diseases in childhood. In: Wachter H, Curtius HCh, Pfleiderer W (eds) Biochemical and clinical aspects of pteridines. de Gruyter, Berlin New York, pp 157–171

    Google Scholar 

  18. Lefford M (1975) Delayed hypersensitivity and immunity in tuberculosis. Am Rev Respir Dis 111:243–245

    PubMed  CAS  Google Scholar 

  19. Lenzini L, Rottoli L (1979) The spectrum of human tuberculosis. Clin Exp Immunol 27:230–237

    Google Scholar 

  20. Lieberman GJ (1958) Tables for one sided statistical tolerance limits. Industrial Quality Control 14:7–9

    Google Scholar 

  21. Malaviya AN, Sehgal KL, Kumar R, Dingley HB (1975) Factors of delayed hypersensitivity in pulmonary tuberculosis. Am Rev Respir Dis 112:49–52

    PubMed  CAS  Google Scholar 

  22. Margreiter R, Fuchs D, Hausen A, Huber Ch, Reibnegger G, Spielberger M, Wachter H (1983) Neopterin as a new biochemical marker for early diagnosis of allograft rejection: experience based upon evaluation of 100 consecutive cases. Transplantation 36:650–653

    Article  PubMed  CAS  Google Scholar 

  23. Murray DN, Echeverri A (1978) Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am Rev Respir Dis 118:827–834

    Google Scholar 

  24. Smith JA, Reichman LB (1972) Lymphocyte transformation. An aid in the diagnosis of tuberculosis in patients with nonreactive skin tests. Am Rev Respir Dis 106:194–201

    PubMed  CAS  Google Scholar 

  25. Wachter H, Hausen A, Grassmayr K (1979) Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases. Hoppe-Seyler’s Z Physiol Chem 360:1957–1960

    PubMed  CAS  Google Scholar 

  26. Wachter H, Fuchs D, Hausen A, Reibnegger G (1982) Importance of pteridines for regulation of growth. In: Wachter H, Curtius HCh, Pfleiderer W (eds) Biochemical and clinical aspects of pteridines. de Gruyter, Berlin New York, pp 277–281

    Google Scholar 

  27. Wachter H, Fuchs D, Hausen A, Reibnegger G (1983) The role of pteridines in regulation of growth. In: Blair JA (ed) Chemistry and biology of pteridines. de Gruyter, Berlin New York, pp 403–407

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fuchs, D., Hausen, A., Kofler, M. et al. Neopterin as an index of immune response in patients with tuberculosis. Lung 162, 337–346 (1984). https://doi.org/10.1007/BF02715666

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02715666

Key words

Navigation