Abstract
Neopterin levels have been reported elevated in diseases with changed cellular immune response. The study reported here was designed to examine whether serum neopterin (S-neopterin) could be a marker of activity in sarcoidosis.
S-neopterin was measured by radioimmunoassay in 37 patients with inactive and 34 patients with active sarcoidosis and in 38 controls. The levels were significantly elevated in both sarcoid groups and increased in stage III compared to I and II. S-neopterin levels were significantly correlated to levels of serum angiotensin-converting enzyme (SACE) and immunoglobulins IgG and IgA. The results indicate that S-neopterin may be a marker of activity in sarcoidosis.
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References
Bergström K, Lefvert AK (1980) An automated turbidometric immunoassay for plasma proteins. Scand J Clin Lab Invest 40:637–640
Crystal RG, Hunninghake GW, Gadek JE, Keogh BA, Rennard SI, Bitterman PB (1983) State of the art: the pathogenesis of sarcoidosis. In: Chrétien J, Marsac J, Saltiel JC (eds) Ninth international conference on sarcoidosis and other granulomatous disorders. Pergamon Press, Paris: pp 13–35
Daniele RP (1983) Abnormalities of the humoral immune system in sarcoidosis. In: Fanburg BL (ed) Sarcoidosis and other granulomatous diseases of the lung. Marcel Dekker, New York, pp 225–242
Daniele RP, Dauber JH, Rossman MD (1980) Immunologic abnormalities in sarcoidosis. Ann Intern Med 92:406–416
DuBois RM, Turner-Warwick M (1983) Bronchoalveolar macrophages in sarcoidosis. In: Chrétien J, Marsac J, Saltiel JC (eds) Ninth international conference on sarcoidosis and other granulomatous disorders. Pergamon Press, Paris, pp 55–62
Fanburg BL (1983) Serum angiotensin-1-converting enzyme in the diagnosis and determination of activity of sarcoidosis. In: Fanburg BL (ed) Sarcoidosis and other granulomatous diseases of the lung. Marcel Dekker, New York, pp 263–272
Fuchs D, Hausen A, Kofler M, Kosanowski H, Reibnegger G, Wachter H (1984) Neopterin as an index of immune response in patients with tuberculosis. Lung 162:337–346
Huber C, Batchelor R, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J, Wachter H (1984) Immune response-associated production of neopterin: release from macrophages primarily under control of interferon-gamma. J Exp Med 160:310–316
Huber C, Fuchs D, Hausen A, Margreiter R, Reibnegger G, Spielberger M, Wachter H (1983) Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. J Immunol 130:1047–1050
Hunninghake GW, Crystal RG (1981) Pulmonary sarcoidosis. A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 305:429–434
Hunninghake GW, Fulmer JD, Young RC Jr, Gadek JE, Crystal RG (1979) Localization of the immune response in sarcoidosis. Am Rev Respir Dis 120:49–57
Kern P, Rokos, Dietrich M (1984) Raised serum neopterin levels and imbalances of T-lymphocyte subsets in viral diseases, acquired immune deficiency and related lymphadenopathy syndromes. Biomed Pharmacother 38:407–411
Lieberman J (1975) Elevation of serum angiotensin-converting enzyme level in sarcoidosis. Am J Med 59:365–372
Margreiter R, Fuchs D, Hausen A, Huber C, Reibnegger G, Spielberger M, Wachter H (1983) Neopterin as a new biochemical marker for diagnosis of allograft rejection: experience based upon evaluation of 100 consecutive cases. Transplantation 36:650–653
Nakamura M, Manser T, Pearson GDN, Daley MJ, Gefter ML (1984) Effect of IFN-γ on the immune response in vivo and on gene expression in vitro. Nature 307:381–382
Rocklin RE (1983) Cell-mediated immunity in sarcoidosis. In: Fanburg BL (ed) Sarcoidosis and other granulomatous diseases of the lung. Marcel Dekker, New York, pp 203–224
Ryan JW, Ryan US, Schultz DR, Whitaker C, Chung A, Dorer FC (1975) Subcellular localization of pulmonary angiotensin-converting enzyme (kininase II). Biochem J 146:497–499
Sidman CL, Marshall JD, Shultz LD, Gray PW, Johnson HM (1984)γ-Interferon is one of several direct B cell-maturing lymphokines. Nature 309:801–803
Silverstein E, Pertschuk LP, Friedland J (1979) Immunofluorescent localization of angiotensin-converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc Natl Acad Sci 76 (12):6646–6648
Venet A, Hance AJ, Saltini C, Robinson BWS, Crystal RB (1985) Enhanced alveolar macrophage-mediated antigen-induced T lymphocyte proliferation in sarcoidosis. J Clin Invest 75:293–301
Wachter H, Hausen A, Grassmayr K (1979) Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases. Hoppe-Seylers Z Physiol Chem 360:1957–1960
Ziegler I, Hamm U, Berndt J (1983) Participation of pterins in the control of lymphocyte stimulation and lymphoblast proliferation. Cancer Res 43:5356–5359
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Eklund, A., Blaschke, E. Elevated serum neopterin levels in sarcoidosis. Lung 164, 325–332 (1986). https://doi.org/10.1007/BF02713657
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DOI: https://doi.org/10.1007/BF02713657