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Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx

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Abstract

Introduction

Basaloid is a rare and poorly-differentiated variant of squamous cell carcinoma of the larynx, with an invasive solid growth of cells in a lobular configuration. Different molecular markers, such as p53, Ki-67 and E-cadherin, have been shown to be prognostic factors in head and neck cancer.

Objective

To evaluate the relationship between the immunoexpression of p53, Ki-67 and E-cadherin in relation to prognosis in basaloid squamous cell carcinoma of the larynx (BSCCL)

Patients and methods

We retrospectively studied 11 cases of BSCCL, all male with a mean age of 62.4 years. Immunohistochemical analyses were performed on paraffin-embedded tissues using p53 (DO-7), Ki-67 (MIB-1) and E-cadherin (56B5) antibodies. Quantitative assessments of the expression and descriptive statistical analyses were performed.

Results

In 72.7% of the cases, clinically advanced stages III–IV were diagnosed. Average survival time was 56.09 months, and 72.7% of patients died as a consequence of the tumour. Immunoreactivity of p53 (>10% of cells) was detected in the 81.8% of the cases. The 72.7% of the cases showed overexpression of Ki-67 (>50% of cells). The cases with low immunoexpression of Ki-67 and p53 had the best clinicopathological data. All cases showed a decreased expression of E-cadherin.

Conclusions

BSCCL is an aggressive variant of the squamous cell carcinoma and has a high expression of p53 and Ki-67 with a low expression of E-cadherin. These results could be related to the aggressiveness of the disease and its poor prognosis.

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Authors and Affiliations

  1. Unidad de Patología Oral y Maxilofacial, Universidad del País Vasco (Euskal Herriko Unibertsitatea-EHU-), Leioa, Vizcaya, España

    María J. Rodríguez Tojo & José M. Aguirre Urízar

  2. Servicio de Otorrinolaringología, Hospital San Millán-San Pedro, Logroño, La Rioja, España

    Francisco J. García Cano & Juan C. Infante Sánchez

  3. Servicio de Anatomía Patológica, Hospital San Millán-San Pedro, Logroño, La Rioja, España

    E. Velázquez Fernández

Authors
  1. María J. Rodríguez Tojo
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  2. Francisco J. García Cano
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  3. Juan C. Infante Sánchez
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  4. E. Velázquez Fernández
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  5. José M. Aguirre Urízar
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Correspondence to José M. Aguirre Urízar.

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Rodríguez Tojo, M.J., García Cano, F.J., Infante Sánchez, J.C. et al. Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. Clin Transl Oncol 7, 110–114 (2005). https://doi.org/10.1007/BF02708743

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  • DOI: https://doi.org/10.1007/BF02708743

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