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Sugar amino acids and related molecules: Some recent developments

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Abstract

To meet the growing demands for the development of new molecular entities for discovering new drugs and materials, organic chemists have started working on many new concepts that can help to assimilate knowledge-based structural diversities more efficiently than ever before. Emulating the basic principles followed by Nature to build its vast repertoire of biomolecules, organic chemists are developing many novel multifunctional building blocks and using them to create ‘nature-like’ and yet unnatural organic molecules. Sugar amino acids constitute an important class of such polyfunctional scaffolds where the carboxyl, amino and hydroxyl termini provide an excellent opportunity to organic chemists to create structural diversities akin to Nature’s molecular arsenal. In recent years, sugar amino acids have been used extensively in the area of peptidomimetic studies. Advances made in the area of combinatorial chemistry can provide the necessary technological support for rapid compilations of sugar amino acidbased libraries exploiting the diversities of their carbohydrate frameworks and well-developed solid-phase peptide synthesis methods. This perspective article chronicles some of the recent applications of various sugar amino acids, furan amino acids, pyrrole amino acids etc. and many other related building blocks in wide-ranging peptidomimetic studies

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Authors and Affiliations

  1. Indian Institute of Chemical Technology, 500 007, Hyderabad, India

    Tushar Kanti Chakraborty, Pothukanuri Srinivasu, Subhasish Tapadar & Bajjuri Krishna Mohan

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  1. Tushar Kanti Chakraborty
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  2. Pothukanuri Srinivasu
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  3. Subhasish Tapadar
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  4. Bajjuri Krishna Mohan
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Chakraborty, T.K., Srinivasu, P., Tapadar, S. et al. Sugar amino acids and related molecules: Some recent developments. J Chem Sci 116, 187–207 (2004). https://doi.org/10.1007/BF02708268

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  • DOI: https://doi.org/10.1007/BF02708268

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