Abstract
The topic of this article is the relation between bottom-up and top-down, reductionist and “holistic” approaches to the solution of basic biological problems. While there is no doubt that the laws of physics apply to all events in space and time, including the domains of life, understanding biology depends not only on elucidating the role of the molecules involved, but, to an increasing extent, on systems theoretical approaches in diverse fields of the life sciences. Examples discussed in this article are the generation of spatial patterns in development by the interplay of autocatalysis and lateral inhibition; the evolution of integrating capabilities of the human brain, such as cognition-based empathy; and both neurobiological and epistemological aspects of scientific theories of consciousness and the mind.
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References
Crick F and Koch C 1998 Consciousness and neuroscience;Cereb. Cortex 8 97–107
Dehaene S, Kerszberg M and Changeux J P 1998 A neuronal model of a global workspace in effortful cognitive tasks;Proc. Natl. Acad. Sci. USA 95 14529–14534
Eichler E E 2001 Recent duplication, domain accretion and the dynamic mutation of the human genome;Trends Genet. 17 661–669
Gallese V and Goldman A 1998 Mirror neurons and the simulation theory of mind-reading;Trends Cognitive Sci. 2 493–501
Gierer A and Meinhardt H 1972 A theory of biological pattern formation;Kybernetik 12 30–39
Gierer A 1981 Generation of biological patterns and form: Some physical, mathematical and logical aspects;Prog. Biophys. Mol. Biol. 37 1–47
Gierer A 1983 Relation between neurophysiological and mental states: Possible limits of decodability;Naturwissenschaften 70 282–287
Gierer A 1998 Networks of gene regulation, neural development and the evolution of general capabilities, such as human empathy;Z. Naturforsch. 53C 716–722
Granero M I, Porati A and Zanacca D 1977 A bifurcation analysis of pattern formation in a diffusion governed morphogenetic field;J. Math. Biol. 4 21–27
Harrison L G 1993Kinetic theory of living pattern (Cambridge: Cambridge University Press)
Hartline H K, Wagner H G and Ratliff F 1956 Inhibition in the eye of limulus;J. Gen. Physiol. 39 651–673
Kirschfeld B and Reichardt W 1964 Die Verarbeitung stationrer optischer Nachrichten im Komplexauge von Limulus;Kybernetik 2 43–61
Lorenz K 1973Die Rückseite des Spiegels. Versuch einer Naturgeschichte menschlicher Erkenntnis (München: Piper)
Meinhardt H and Gierer A 1980 Generation and regeneration of sequences of structures during morphogenesis;J. Theor. Biol. 85 429–450
Meinhardt H 1982Models of biological pattern formation (London: Academic Press)
Meinhardt H and Gierer A 2000 Pattern formation by local self-activation and lateral inhibition;BioEssays 33 753–760
Murray J D 1989Mathematical biology (Heidelberg: Springer)
Pääbo S 2001 The human genome and our view of ourselves;Science 291 1219–1220
Povinelli D J and Preuss T M 1995 Theory of mind. Evolutionary history of a cognitive specialization;Trends Neurosci. 18 418–424
Reid C 1970Hilbert (Heidelberg: Springer)
Rizzolati G, Fogassi L and Gallese V 2001 Neurophysiological mechanisms underlying the understanding and imitation of action;Nature Rev. Neurosci. 2 661–670
Roe S A 1982Matter life and generation. 18th century embryology and the Haller-Wolff debate (Cambridge: Cambridge University Press)
Trembley A 1744Mémoires pour servir à l’histoire d’un genre de polypes d’eau douce à bras en forme de cornes (Leiden: Jean and Herman Verbeek)
Turing A 1952 The chemical basis of morphogenesis;Philos. Trans. R. Soc. London Ser. B 237 37–72
Wolff C F 1759Theoria generationis (Halle)
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Gierer, A. Theoretical approaches to holistic biological features: Pattern formation, neural networks and the brain-mind relation. J Biosci 27, 195–205 (2002). https://doi.org/10.1007/BF02704909
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DOI: https://doi.org/10.1007/BF02704909