Abstract
Involvement of pineal and its major hormone, melatonin, in the process of erythropoiesis in a freshwater catfish,Clarias batrachus has been investigated. The study was conducted during four phases, namely preparatory phase, spawning phase, postspawning phase and late postspawning phase of its annual reproductive cycle. During each phase a fish received either melatonin injections or subjected to pinealectomy. In addition, each fish in all the groups, received either iopanoic acid or cyproterone acetate or vehicle in the morning or late afternoon. Results clearly indicate that melatonin stimulates the rate of erythropoiesis inClarias batrachus. It appears that the extent of stimulation depends upon the phase of the annual reproductive cycle. However, in general, the pineal-or melatonin-induced modulation of blood variables is gonad dependent and thyroid seems to play a time of the day dependent subtle role
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References
Agha A K and Joy K P 1987 Effect of pinealectomy on thyroidal131I uptake during different phases of gonadal cycle of the Indian catfish,Heteropneustes fossilis (Bloch);Indian J. Exp. Biol. 25 228–229
Creighton J and Rudeen P K 1989 Effects of melatonin and thyroxine treatment on reproductive organs and thyroid hormone levels in male hamsters;Pineal Res. 6 317–324
Dacie J V and Lewis S M 1977Practical haematology (Edinburgh: ELBS/Churchill Livingstone)
Datta A G 1975 Erythropoietin: Biological role and biosynthesis; inTrends in hematology (eds) N N Sen and A K Basu (Calcutta: J B Chatterjee Memorial Committee and School of Tropical Medicine) pp 323–348
De Vlaming V and Olcese J 1981 The pineal and reproduction in fish, amphibians and reptiles; inThe pineal gland, vol. II, Reproductive effects (ed.) R J Reiter (Florida: CRC Press) pp 1–29
Galton V A 1989 The role of 3,5,3-tri-iodothyronine in the physiological action of thyroxine in the premetamorphic tadpole;Endocrinology 125 2427–2433
Gupta G, Srivastava A and Sethy B S 1989 Effect of antiandrogens on some key enzymes of glycolysis in epididymis and ventral prostate of rat;Indian J. Exp. Biol. 27 324–328
Haldar-Misra C and Thapliyal J P 1981 Response of reptilian gonad to melatonin;Neuroendocrinology 33 328–332
Haus E, Lakatua D, Swoyer J and Sackett-Lundeen L 1983 Chronobiology in hematology and immunology;Am. J. Anat. 168 467–517
Hrushesky W J M, Martynowicz M, Markiewicz M, Von Roemeling R, Wood P A and Sanchez de la Pena S 1992 Chronotherapy of cancer: a major drug delivery challenge;Adv. Drug Delivery Rev. 9 1–83
James W F, Samuels A I and Malager L A 1971 Androgen and erythropoiesis;Israel J. Med. Sci. 7 892–900
Joy K P and Khan I A 1991 Pineal-gonadal relationship in the teleostChanna punctatus (Bloch): Evidence for possible involvement of hypothalamic serotonergic system;J. Pineal Res. 11 12–22
Kaur R J and Thapliyal J P 1975 Hemopoietic response to male hormone in chequered water snake,Natrix piscator;Gen. Comp. Endocrinol. 27 203–208
Laerum O D and Smaaland R 1989 Rhythms in blood and bone marrow: potential therapeutic implications; inChronopharmacology, cellular and biochemical interactions (ed.) B Lemmer (New York: Marcel Dekker) pp 371–393
Leonard J L and Visser T J 1986 Biochemistry of deiodination; inThyroid hormone metabolism (ed.) G Hennemann (New York: Marcel Dekker) pp 189–229
Nayak P K and Singh T P 1987a Effect of melatonin and 5-methoxytryptamine on sex steroids and thyroid hormones during the prespawning phase of the annual reproductive cycle in the freshwater teleost,Clarias batrachus;J. Pineal Res. 4 377–386
Nayak P K and Singh T P 1987b Effect of pinealectomy on thyroid hormone (T 4 andT 3) levels in plasma during annual reproductive cycle in the freshwater catfish,Clarias batrachus;J. Pineal Res. 4 387–394
Nayak P K and Singh T P 1988 Effect of pinealectomy on testosterone, estradiol-17β, estrone, and 17 α-hydroxyprogesterone levels during the annual reproductive cycle in the freshwater catfish,Clarias batrachus;J. Pineal Res. 5 419–426
Pati A K and Gupta G 1992 Late afternoon administration of melatonin is prosomatotrophic and exerts androgen independent effects on erythropoiesis in male house sparrow,Passer domesticus;Indian J. Exp. Biol. 30 173–177
Pati A K and Gupta S 1991 Circadian time dependence of erythropoietic and respiratory responses of Indian garden lizard,Calotes versicolor, to mammalian urinary erythropoietin and thyroxine;Gen. Comp. Endocrinol. 82 345–354
Pati A K and Thapliyal J P 1984 Erythropoietin, testosterone and thyroxine in the erythropoietic response of the snake,Xenochrophis piscator;Gen. Comp. Endocrinol. 53 370–374
Pevet P 1988 The role of the pineal gland in the photoperiodic control of reproduction in diferent hamster species;J. Reprod. Nutr. Dev. 28 443–458
Reiter R J 1980 The pineal and its hormone in the control of reproduction in mammals;Endocr. Rev 1 109–131
Reiter R J (ed.) 1981The pineal gland, Vol II, Reproductive effects (Florida: CRC Press)
Robinzon B and Rogers J G Jr 1979 The effect of gonadal and thyroidal hormones on the regulation of food intake and adiposity, and on various endocrine glands, in the redwinged blackbird(Agelaius phoeniceus);Gen. Comp. Endocrinol. 38 135–147
Rowe J W 1971 Relation of pineal gland and environmental lighting to thyroid function in rat;Neurobiology. 6 247
Shahidi N T 1973 Androgen and erythropoiesis;N. Engl J. Med. 289 272–280
Shedpure M and Pati A K 1993 Melatonin-induced metabolic changes in a freshwater catfish;J. Ravishankar Univ. 6 29–36
Shedpure M and Pati A K 1995a Circannual variation in the effects of melatonin and pinealectomy on erythropoiesis and intermediary metabolism in a catfish;J. Parasit. ApplAnim. Biol. 4 55–72
Shedpure M and Pati A K 1995b The pineal gland: Structural and functional diversity;Indian J. Exp. Biol. 33 625–640
Silva J E, Leonard J L, Crantz F R and Larsen P R 1982 Evidence for two tissue-specific pathways forin vivo thyroxine 5′-deiodination in the rat;J. Clin. Invest. 69 1176–1184
Snedecor G W and Cochran W G 1994Statistical methods 8th edition (New Delhi: Affiliated East-West Press and Iowa: Iowa State University press)
Stebbins R C and Cohen N W 1973 The effect of parietalectomy on the thyroid and gonads in free living western fence lizard,Sceloporus occidentalis;Copeia 662–668
Tews G, Arzt W and Murschedlmayr G 1988 Pregnancy Continued after the ingestion of cyproterone acetate in the first trimester;Gynaekol. Rundsch. 28 193–197
Thapliyal J P 1980 Thyroid in reptiles and birds; inHormones, adaptations and evolution (eds) S Ishii, T Hirano and M Wada (Tokyo: Japan Sci. Soc. Press and Berlin: Springer Verlag) pp 241–250
Thapliyal J P and Kaur R J 1976 Effect of thyroidectomy, 1-thyroxine and temperature on hemopoiesis in the chequered water snake,Natrix piscator;Gen. Comp. Endocrinol. 30 182–188
Thapliyal J P, Pati A K and Gupta B B Pd 1982 The role of erythropoietin, testosterone, and 1-thyroxine in the tissue oxygen consumption and erythropoiesis of spotted munia,Lonchura punctulata;Gen. Comp. Endocrinol. 48 84–88
Turner C D and Bagnara J T 1976General endocrinology (Tokyo: Toppan Company)
Vollrath L 1981The pineal organ (Berlin, Heidelberg, New York: Springer-Verlag)
Vriend J 1983 Pineal-thyroid interactions;Pineal Res. Rev. 1 183–206
White W F, Hedlund M T, Weber G F, Rippel R H. Johnson E S and Wilber J F 1974 The pineal gland: a supplemental source of hypothalamic-releasing hormones;Endocrinology 94 1422–1426
Wide L, Bengtsson C and Birgegard G 1989 Circadian rhythm of erythropoietin in human serum;Br. J. Haematol. 72 85–90
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Shedpure, M., Pati, A.K. Do thyroid and testis modulate the effects of pineal and melatonin on haemopoietic variables inClarias batrachus?. J. Biosci. 21, 797–808 (1996). https://doi.org/10.1007/BF02704721
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DOI: https://doi.org/10.1007/BF02704721