Abstract
Jacalin has been found to agglutinate Ehrlich ascites cells. The agglutination was inhibited by α-glycosides of D-Gal and β -D-Gal(1 → 3)-D-GalNAc suggesting that the lectin-ascites interaction was carbohydrate-specific. There was 21.8% inhibition of tumour (ascites) cell growthin vivo in mice administered 50μg of jacalin by injection for 6 days following intraperitoneal injection of ascites cells. Administration of 100, 150 and 200μg jacalin resulted in 40.2, 57.5 and 83% inhibition respectively. Thein vivo inhibition of tumour cells growth by jacalin was due to its preferential binding with D-Gal-α -(1 → 6) present as terminal residues in the glycoprotein on tumour cell surface.
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Abbreviations
- EAC:
-
Ehrlich ascites cell
- i.p.:
-
intraperitoneal
- GS:
-
Griffonia simplicifolia
- JFL:
-
jackfruit lectin
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Ahmed, H., Chatterjee, B.P. & Debnath, A.K. Interaction andin vivo growth inhibition of Ehrlich ascites tumor cells by jacalin. J. Biosci. 13, 419–424 (1988). https://doi.org/10.1007/BF02703454
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DOI: https://doi.org/10.1007/BF02703454