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Strontium-calcium discriminationin vitro by rat tissues

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Abstract

Uptake of89Sr and45Ca by 15 soft tissues of adult rat was studiedin vitro to assess the extent of discrimination between Sr and Ca. While brain, kidney, placenta and uterus have lower uptake of89Sr and 45 Ca that of diaphragm, lactating mammary gland, skeletal muscle, skin, spleen and testes is higher. Tissues with medium range uptake are heart, small intestine, liver, lung, non-lactating mammary gland and ovary. The 6 tissues displaying discriminating ability, as expressed by89Sr/45Ca (tissue/medium), in the decreasing order are: small intestine, kidney, lactating mammary gland, placenta, diaphragm and heart. Non-lactating mammary gland and the other tissues did not differentiate between Sr and Ca. The efect of several enzyme inhibitors, compounds influencing Sr-Ca metabolism and other factors was studied in terms of the nature and mechanism of Sr-Ca discrimination.

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Abbreviations

DNP:

2-4-Dinitrophenol

OR:

observed ratio

References

  • Comar, C. L. (1955)Radioisotopes in biology and agriculture (New York: McGraw Hill) p. 191, 303

    Google Scholar 

  • Comar, C. L. (1963) inThe transfer of calcium and strontium across the biological membranes (ed. R. H. Wasserman) (New York, London: Academic Press) p. 405.

    Google Scholar 

  • Comar, C. L. and Wasserman, R. H. (1964) inThe mineralmetabolism–an advanced treatise (eds C. L. Comar and F. Bronner) (London, New York: Academic Press) Vol. 2, Part A, p. 523.

    Google Scholar 

  • Comar, C. L., Wasserman, R. H. and Nold, M. M. (1956)Proc. Soc. Exp. Biol. Med.,92, 859.

    PubMed  CAS  Google Scholar 

  • Catsch, A. (1957)Naturwissenschaften,44, 94.

    Article  CAS  Google Scholar 

  • Della Rosa, R. J., Smith, F. A. and Stannard, J. N. (1961)Int. J. Radiat. Biol.,3, 557.

    Article  PubMed  CAS  Google Scholar 

  • Ebashi, S. and Lipmann, F. (1962)J. Cell. Biol.,14, 389.

    Article  CAS  Google Scholar 

  • Kimberg, D. V., Schachter, D. and Schenker, H. (1961)Am. J. Physiol.,200, 1256.

    PubMed  CAS  Google Scholar 

  • Kshirsagar, S. G. (1976a)J. Nutr.,106, 1475.

    PubMed  CAS  Google Scholar 

  • Kshirsagar, S. G. (1976b)Indian J. Exp. Biol.,14, 424.

    PubMed  CAS  Google Scholar 

  • Kshirsagar, S. G. (1977a)Int. J. Radiat. Biol.,32, 561.

    Article  CAS  Google Scholar 

  • Kshirsagar, S. G. (1977b)Indian J. Exp. Biol.,15, 447.

    PubMed  CAS  Google Scholar 

  • Kshirsagar, S. G., Lloyd, E. and Vaughan, J. (1966)Br. J. Radiol.,39, 131.

    Article  Google Scholar 

  • Lengemann, F. W. (1960)J. Biol. Chem.,233, 1859.

    Google Scholar 

  • Menczel, J. and Mor, E. (1972) inSecond International Conference on Strontium Metobolism, USAEC report, Conf720818, p. 273.

  • Martonosi, A., Pucell, A. G. and Halpin, R. A. (1971) inCellular mechanisms for calcium transfer and homeostasis (eds G. Nichols Jr and R. H. Wasserman) (New York, London: Academic Press) p. 175.

    Google Scholar 

  • Olson, E. J. and Cazart, R. J. (1969)J. Gen. Physiol.,33, 311.

    Article  Google Scholar 

  • Schachter, D., Dowdle, E. B. and Schenker, H. (1960)Am. J. Physiol.,198, 275.

    PubMed  CAS  Google Scholar 

  • Schachter, D., Kimberg, D. V. and Schenker, H. (1961)Am. J. Physiol.,200, 1263.

    PubMed  CAS  Google Scholar 

  • Schubert, J. and Lindenbaum, A. (1952)Am. Chem. Soc. J.,74, 3529.

    Article  CAS  Google Scholar 

  • Shane, A. M. (1963) inThe transfer of calcium and strontium across the biological membranes (ed. R. H. Wasserman) (New York, London: Academic Press) p. 359.

    Google Scholar 

  • Taylor, D. M. (1964) inAbstracts VIII of the 6th International Congress on Biochemistry, New York, Abstract No. 104.

  • Taylor, D. M. (1967) inStrontium metabolism (eds J. M. A. Lenihan, J. F. Loutit and J. H. Martin) (London, New York: Academic Press) p. 175.

    Google Scholar 

  • Twardock, A. R. (1963) inThe transfer ofcalcium and strontium across the biological membranes (ed. R. H. Wasserman) (New York, London: Academic Press) p. 327.

    Google Scholar 

  • Twardock, A. R., Prinz, W. H. and Comar, C. L. (1960)Arch. Biochem. Biophys.,89, 309.

    Article  PubMed  CAS  Google Scholar 

  • Walser, M. and Robinson, B. H. B. (1963) inThe transfer of calcium and strontium across the biological membranes (ed. R. H. Wasserman) (New York, London: Academic Press) p. 305.

    Google Scholar 

  • Wasserman, R. H. (1960)Proc. Soc. Exp. Biol. Med.,104, 92.

    PubMed  CAS  Google Scholar 

  • Wasserman, R. H. (1964)Nature (London),201, 997.

    Article  CAS  Google Scholar 

  • Wasserman, R. H., Corradino, R. A. and Taylor, A. N. (1968)J. Biol. Chem.,243, 3978.

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Biochemistry Division, Bhabha Atomic Research Centre, 400 085, Bombay, India

    S. G. Kshirsagar

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  1. S. G. Kshirsagar
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Kshirsagar, S.G. Strontium-calcium discriminationin vitro by rat tissues. Journal of Biosciences 9, 129–135 (1985). https://doi.org/10.1007/BF02702687

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  • DOI: https://doi.org/10.1007/BF02702687

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