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Paraneoplastic pemphigus associated with fludarabine use

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Abstract

Paraneoplastic pemphigus is a severe mucocutaneous disease associated with B-cell lymphoproliferative disorders. A 51-yr-old man presented to the oncology clinic with mucocutaneous skin lesions after six cycles of fludarabine for non-Hodgkin’s lymphoma. A punch biopsy from the skin showed suprabasal acantholysis and blister formation in the epidermis and upper dermis. Direct immunofluorescence demonstrated intercellular IgG deposition in all epidermal layers and complement (C3) at the basement membrane. The indirect immunofluorescence on rat bladder showed intercellular binding of IgG. These findings were consistent with paraneoplastic pemphigus associated with fludarabine use. The temporal association between fludarabine use and paraneoplastic pemphigus suggests there is an etiopathological link between these two entities.

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Authors and Affiliations

  1. Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Medical Oncology, Istanbul University, Istanbul, Turkey

    Ozcan Yildiz, Mustafa Ozguroglu MD, M. Teoman Yanmaz, Hande Turna, Sabiha Gokcen Kursunoglu & Evin Buyukunal

  2. Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul University, Istanbul, Turkey

    Meltem Antonov & Server Serdaroglu

  3. Cerrahpasa Medical Faculty, Department of Pathology, Istanbul University, Istanbul, Turkey

    Cuyan Demirkesen

Authors
  1. Ozcan Yildiz
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  2. Mustafa Ozguroglu MD
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  3. M. Teoman Yanmaz
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  4. Hande Turna
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  5. Sabiha Gokcen Kursunoglu
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  6. Meltem Antonov
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  7. Server Serdaroglu
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  8. Cuyan Demirkesen
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  9. Evin Buyukunal
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Corresponding author

Correspondence to Mustafa Ozguroglu MD.

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Yildiz, O., Ozguroglu, M., Yanmaz, M.T. et al. Paraneoplastic pemphigus associated with fludarabine use. Med Oncol 24, 115–118 (2007). https://doi.org/10.1007/BF02685912

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  • DOI: https://doi.org/10.1007/BF02685912

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