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A clinical study of docetaxel with or without 5′DFUR as a second-line chemotherapy for advanced gastric cancer

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Abstract

We conducted a clinical pilot study to evaluate the efficacy and safety of the combination of docetaxel and 5′DFUR as a second-line chemotherapy for gastric cancer. Twenty-four patients were divided into two groups by simple randomization: group A (60 mg/m2 of docetaxel, every 3 wk) and group B (regimen A + 600 mg/body of 5′DFUR). The response rate was 17% and 42% in group A and B, respectively (p<0.05). The MST from the start of the first-line was 17 mo in group B. The major adverse event was leukopenia in both groups.

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Authors and Affiliations

  1. Department of Surgery, Iida Municipal Hospital, Japan

    Manabu Hiraguri

  2. Department of Surgery, Hokushin General Hospital, Japan

    Yoshiro Fujimori

  3. Department of Surgery, Nagano National Hospital, Japan

    Fumiaki Shimizu

  4. Department of Surgery, Nagano Prefectural Kiso Hospital, Japan

    Shigeyoshi Kumeda

  5. Department of Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Fukuto Maruta MD, PhD, Satoshi Ishizone & Shinichi Miyagawa

Authors
  1. Fukuto Maruta MD, PhD
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  2. Satoshi Ishizone
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  3. Manabu Hiraguri
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  4. Yoshiro Fujimori
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  5. Fumiaki Shimizu
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  6. Shigeyoshi Kumeda
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  7. Shinichi Miyagawa
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Corresponding author

Correspondence to Fukuto Maruta MD, PhD.

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Maruta, F., Ishizone, S., Hiraguri, M. et al. A clinical study of docetaxel with or without 5′DFUR as a second-line chemotherapy for advanced gastric cancer. Med Oncol 24, 71–75 (2007). https://doi.org/10.1007/BF02685905

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  • DOI: https://doi.org/10.1007/BF02685905

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