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Dendritic cells and the immunopathogenesis of systemic lupus erythematosus

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Abstract

Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function, the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored.

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  1. Division of Rheumatology, University of Michigan, 5520 MSRBI, 1150 W. Medical Center Drive, BOX 0680, 48109, Ann Arbor, MI

    Seetha Monrad & Mariana J. Kaplan MD

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Monrad, S., Kaplan, M.J. Dendritic cells and the immunopathogenesis of systemic lupus erythematosus. Immunol Res 37, 135–145 (2007). https://doi.org/10.1007/BF02685895

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