Abstract
The antioxidative effects of spermine, spermidine and putrescine were determined by measurement of primary and secondary oxidation products of polyunsaturated fatty acids, using gas and liquid chromatography as well as spectrophotometric recordings. It was demonstrated that polyamines inhibit the oxidation of polyunsaturated fatty acids,α-tocopherol and carotenoid pigments. Both linear and nonlinear dose/response relationships have been observed. The efficiency of a given polyamine was correlated with the number of amine groups in the molecule. Spermine was, thus, more efficient than spermidine, which in turn had a higher efficiency than putrescine. The relative antioxidative effect was as follows: spermine (100.0), spermidine (61.0), putrescine (23.0), ethoxyquin (27.6), ascorbyl palmitate (18.3), octyl gallate (7.9), tert butylhydroquinone (6.3), butylated hydroxyanisole (3.6) andα-tocopherol (3.4).
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References
Labuza, T.P.,CRC Crit. Rev. Food Techn. October:355 (1971).
Ames, B.N.,Science 221:1256 (1983).
Lundberg, W.O., inLipids and Their Oxidation, edited by H.W. Schultz, E.A. Day and R.O. Sinnhuber, Avi Publishing Company, Westport, CT, 1962, p. 31.
Pryor, W.A., inFree Radicals in Biology, Vol. 1, edited by W.A. Pryor, Academic Press, New York, NY, 1976, p. 1.
Butler, J., W.H. Koppenol and E. Margoliash,J. Biol. Chem. 257(18):10141 (1982).
Steelhammer, J.C., I.D. Morrison and L.S. Wittenbrook, U.S. pa- tent 4310438 (1982).
Silverstein, R.M., U.S. patent 3382186 (1968).
Chenicek, J.A., and R.H. Rosenwald, U.S. patent 2738281 (1956).
Chenicek, J.A., U.S. patent 2856292 (1958).
Zürcher, K.,Mitt. Gebiete Lebensm. Hyg. 65:90 (1974).
Dahle, L.K., E.G. Hill and R.T. Holman,Arch. Biochem. Biophys. 98:253 (1962).
Vyncke, W,Fette-Seifen-Anstrichm. 72:1084 (1970).
Draper, H.H., and M. Hadley,Methods Enzymol. 186:421 (1990).
Løvaas, E., and F. Palmieri,Proceedings of 12th FEBS Meeting, Dresden, Germany, Abstr. no. 3302 (1978).
Smith, J.G.M., R. Hardy and K. Young, inProceedings of SAAFOST Symposium: Foods and Their Fats, Pretoria, South Africa, 1972, p. 79.
Bird, R.P., and H.H. Draper, inMethods in Enzymology, Vol. 105, edited by L. Orlando Packer, Academic Press, New York, NY, 1984, p. 299.
Sinnhuber, R.O., and T.C. Yu,J. Food Sci. 23:626 (1958).
Chow, C.K.,Am. J. Clin. Nutr. 32:1066 (1979).
Vyncke, W,Fette-Seifen-Anstrichm. 76:239 (1974).
Chan, H.W.-S., and G. Levett,Lipids 12:99 (1977).
Reyftmann, J.P., R. Santus, P. Morlière and E. Kohen,Photobiochemistry and Photobiophysics 11:191 (1986).
Evans, E.A., B. Vennesland and J.J. Schneider,Proc Soc. Exptl. Biol. Med. 42:467 (1939).
Tadolini, B.,Biochem. J. 249:33 (1988).
Tadolini, B., L. Cabrini, L. Landi, E. Varani and P. Pasquali,Biogenic Amines 3(2):97 (1985).
Mizui, T., N. Shimono and M. Doteuchi,Japan J. Pharmacol 44:43 (1987).
Kitada, M., Y. Naito, K. Igarashi, S. Hirose, Y. Kanakubo and H. Kitagawa,Res. Commun. Chem. Pathol. Pharmacol 33(3):487 (1981).
Kafy, A.M.L., and D.A. Lewis,Agents and Actions 24:145 (1988).
Kafy, A.M.L., CG. Haigh and D.A. Lewis, Ibid. (1986).
Drolet, G., E.B. Dumbroff, R.L. Legge and J.E. Thompson,Phytochemistry 25(2):361 (1986).
Cohen, S.S., inAdvances in Polyamine Research, Vol. 1, edited by R.A. Campell, D.R. Morris, D. Bartos, G. Doyle Daves Jr. and F. Bartos, Raven Press, New York, NY, 1978, p. 1.
Lovaas, E., EP patent 86850257 (1986).
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Løvaas, E. Antioxidative effects of polyamines. J Am Oil Chem Soc 68, 353–358 (1991). https://doi.org/10.1007/BF02663749
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DOI: https://doi.org/10.1007/BF02663749