Summary
The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients. At three different times during the cycle (first, tenth and twentieth days) each subject received an i.v. infusion of 240 mg theophylline.
Significant changes were found in the kinetics of theophylline according to the menstrual cycle. The maximum plasma drug concentration, minimum mean residence time, and minimum elimination half-life were observed at mid-cycle. The lowest clearance was observed at D 20. The AUC and volume of distribution did not vary significantly during the cycle.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Backstrom P, Jorpes P (1979) Serum phenytoin, phenobarbital, car- bamazepine albumin and plasma estradiol progesterone concen- trations during the menstrual cycle in women with epilepsy. Acta Neurol Scand 58:63–71
Blaive B, Lapalus P, Lemoigne F, Bugnas B (1981) Theophylline: parametres pharmacocindtiques individuels. Application à la determination d’une posologie individuelle efficace. Clin Resp Physio1 17:413–416
Brandstetter V, Kaplanski J, Leibson V, Ben-Zvi Z (1986) The ef- fects of estrus cycle on drug metabolism in the rat. Eur J Drug Metabol Pharmacokinet 11:251–254
Bruguerolle B (1986) Modifications de la pharmacocindtique des mddicaments au cours du cycle menstruel. Thérapie 41:11–17
Bruguerolle B (1986) Modifications de la pharmacocinétique de la theophylline au cours du cycle oestral chez la ratte. Pathol Bio1 35: 181–183
Charpin J (1980) Allergologie. Flammarion, Paris
Gardner MJ, Tornatore KM, Jusko WJ, Kanarkowski R (1983) Ef- fect of tobacco smoking and oral contraceptive use on theo- phylline disposition. Br J Clin Pharmaco1 16:271–280
Jones BM, Jones MK (1976) Alcool effects in women during the menstrual cycle. Ann N Y Acad Sci 273:576–587
Jochemsen R, Van Der Graaf M, Boeijinga JK, Breimer DD (1982) Influence of sex, menstrual cycle and oral contraception on the disposition of nitrazepam. Br J Clin Pharmaco1 13: 319–324
Jonkman JH, Upton RA (1984) Pharmacokinetic drug interactions with theophylline. Clin Pharmacokinet 9: 309–334
Jusko W, Gardner MJ, Mangione A, Schantag JJ, Koup JR, Vance JW (1979) Factors affecting theophylline clairance: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contra- ceptives, benzodiazepines, barbiturates and ethanol. J Pharm Sci 68:1358–1366
Kellerman G, Luyten-Kellerman M, Horning MG, Stafford DM (1976) Elimination of antipyrine and benzo(a)pyrène metabolism in cultured human lymphocytes. Ctin Pharmacol Ther 20:72–80
Miaskewicz SL, Shivelly CA, Vesell ES (1982) Sex differences in ab- sorption kinetics of sodium salicylate. Clin Pharmacol Ther 31: 30–37
Nayak VK, Kshirsagar NA, Desai NK, Satoskar S (1988) Influence of menstrual cycle on antipyrine pharmacokinetics in healthy in- dian female volunteers. Br J Clin Pharmaco1 26:604–606
Roberts RK, Grice J, Mac Muffle C, Heilbronn L (1983) Oral con- traceptive steroids impair the elimination of theophylline. J Lab Clin Med 101:821–825
Shavit G, Lerman P, Korcsyn A (1984) Phenytoin pharmacokinetics in catamenial epilepsy. Neurology 34:959–961
Tornatore KM, Kanarkowski R, Mac Carty TL, Gardner RJ, Yurchak AM, Jusko WJ (1982) Effect of chronic oral contraceptive steroids on theophylline disposition. Eur J Clin Pharmacol 23: 129–134
Wagner JG (1975) Fundamentals of clinical pharmacokinetics. Drug Intelligence, Washington, pp 75–119
Wilson K, Oram M, Horth CE, Burnett D (1982) The influence of the menstrual cycle on the metabolism and clearance of metha- qualone. Br J Clin Pharmaco1 14:333–339
Wojcicki B, Gawronska-Szklarz B, Kaziemier-Czykz B (1979) Com- parative pharmacokinetics of paracetamol in man and women considering follicular and lutheal phases. Arzneim Forsch 29: 350–352
Yamaoka K, Noganawa T, Uno T (1978) Statistical moments in phar- macokinetics. J Pharmacokinet Biopharm 6:547–558
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bruguerolle, B., Toumi, M., Faraj, E. et al. Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics . Eur J Clin Pharmacol 39, 59–61 (1990). https://doi.org/10.1007/BF02657059
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02657059