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Implementation of an osteoporosis research program with a mobile dual-energy X-ray absorptiometry unit: The Montana/Wyoming experience

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Abstract

To expedite recruitment, and subject participation, for a large clinical osteoporosis therapy trial utilizing the bisphosphonate ibandronate, an integrated network of 13 satellite clinical sites was developed, linked by a mobile clinic vehicle transporting a dual-energy X-ray absorptiometry (DXA) unit. A predominantly rural area of the United States (Montana, northern Wyoming) was accessed for the project, due to the large pool of potential subjects living in this area who were not yet involved in osteoporosis clinical studies. The results of the project to date (through 10 months) confirm the feasibility of such a study design, with 1774 subjects screened by DXA for the study, and 280 (15.8%) accepted. The mobile DXA unit has functioned according to specifications for a stationary DXA machine, with the stability of spine phantom measurements over 10 months assessed as a coefficient of variation of 0.46%. The success of the project validates the concept of performing clinical osteoporosis therapy trials in previously underutilized rural community settings, facilitated by a satellite site network and mobile clinic.

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References

  1. Riggs BL, Melton LJ. Involutional osteoporosis. N Engl J Med 1986;14:1676–86.

    Article  Google Scholar 

  2. Notelovitz M. Osteoporosis: screening, prevention, and management. Fertil Steril 1993;59:707–25.

    PubMed  CAS  Google Scholar 

  3. Pak CY, Sakhace K, Adams-Huet B, Piziak V, Peterson RD, Poindexter JR. Treatment of postmenopausal osteoporosis with slow-release sodium fluoride: final report of a randomized controlled trial. Ann Intern Med 1995;123:401–8.

    PubMed  CAS  Google Scholar 

  4. Chesnut CH III, McClung MR, Ensrud KE, et al. Alendronate treatment of the postmenopausal osteoporotic woman: effect of multiple dosages on bone mass and bone remodelling. Am J Med 1995;99:144–52.

    Article  PubMed  CAS  Google Scholar 

  5. Liberman UA, Weiss SR, Broll JB, et al. Effect of oral alendronate on bone mineral density and the incidence of fractures on postmenopausal osteoporosis. N Engl J Med 1995;333:1437–43.

    Article  PubMed  CAS  Google Scholar 

  6. English S, Hamilton C, Carlson-Fisher B, Leitheiser J, Browning M, Chesnut C III. Feasibility of collaborations between university academic centers in the performance of osteoporosis clinical trials. In: Christiansen C, editor. Proceedings of the 4th International Symposium on Osteoporosis. Hong-Kong: Gardiner-Caldwell Communications, 1993:128.

    Google Scholar 

  7. Chesnut CH III. Noninvasive methods for bone mass measurement. In: Avioli LN, editor. The osteoporotic syndrome, 3rd ed. New York: Wiley-Liss, 1993:77–87.

    Google Scholar 

  8. Mazess R, Chesnut CH III, McClung M, Genant HK. Enhanced precision with dual-energy X-ray absorptiometry. Calcif Tissue Int 1992;51:14–7.

    Article  PubMed  CAS  Google Scholar 

  9. Steiger P, Cummings SR, Genant HK, Weiss H. Morphometric x-ray absorptiometry of the spine: correlation in vivo with morphometric radiography. Osteoporos Int 1994;4:238–44.

    Article  PubMed  CAS  Google Scholar 

  10. Lang T, Takada M, Gee R, et al. A preliminary evaluation of the Lunar Expert-XL for bone densitometry and vertebral morphometry. J Bone Miner Res 1997;12:136–43.

    Article  PubMed  CAS  Google Scholar 

  11. Swaddiwudhipong W, Chaovakiratipong C, Nguntra P, Mahsakpan P, Lerdlukanavonge P, Koonchote S. Effect of a mobile unit on changes in knowledge and use of cervical cancer screening among rural Thai women. Int J Epidemiol 1995;24:493–8.

    Article  PubMed  CAS  Google Scholar 

  12. Thompson CJ, Leese GP. The evaluation of mobile screening for diabetic retinopathy. Scot Med J 1995;40:5–7.

    PubMed  CAS  Google Scholar 

  13. Turnbull D, Irwig L, Simpson JM, Donnelly N, Mock P. A prospective cohort study investigating psychosocial predictors of attendance at a mobile breast screening service. Aust J Public Health 1995;19:172–6.

    Article  PubMed  CAS  Google Scholar 

  14. McCoy CB, Khoury EL, Hermanns LS, Bankston L. Mobile mammography: a model program for medically underserved women. Womens Health Issues 1992;2:196–203.

    Article  PubMed  CAS  Google Scholar 

  15. Takeda I, Nishinaka M, Hirooka S, Onoue Y, Yamada M, Imose K. Mass screenings for osteoporosis using computed X-ray densitometry (CXD) in a mobile unit. Jpn J Public Health 1995;42:379–84.

    CAS  Google Scholar 

  16. Wapniarz M, Lchmann R, Randerath O, et al. Precision of dual X-ray absorptiometry and peripheral computed tomography using mobile densitometry units. Calcif Tissue Int 1994;54:219–23.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Osteoporosis Research Group, University of Washington Medical Center, 1959 N.E. Pacific Street, Box 356113, 98195-6113, Seattle, WA, USA

    U. Ulrich & C. H. Chesnut MD, FACP

  2. Deaconess Research Institute, Billings, Montana, USA

    M. Browning & E. V. Gaffney

  3. Boehringer Mannheim GmbH, Mannheim, Germany

    K. -H. Schöter

Authors
  1. U. Ulrich
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  2. M. Browning
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  3. E. V. Gaffney
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  4. K. -H. Schöter
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  5. C. H. Chesnut MD, FACP
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Ulrich, U., Browning, M., Gaffney, E.V. et al. Implementation of an osteoporosis research program with a mobile dual-energy X-ray absorptiometry unit: The Montana/Wyoming experience. Osteoporosis Int 7, 583–588 (1997). https://doi.org/10.1007/BF02652566

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  • DOI: https://doi.org/10.1007/BF02652566

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