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Transarterial internal radiation therapy with I-131 lipiodol for multifoca hepatocellular carcinoma: Immediate and long-term results

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Abstract

Transarterial internal radiation with I-131 Lipiodol (TAIR) was performed in 21 patients with multifocal hepatic carcinoma. Eight patients were treated by TAIR alone and 13 by combination of TAIR and intraarterial infusion ofcis-diamminedichloroplatinum (CDDP) and/or adriamycin mitomycin C oil suspension (ADMOS). TAIR was found effective immediately and long-term. Serum α-fetoprotein (AFP) levels dropped to 50% or less in 7 of 14 patients. Eleven of 21 patients (52%) showed 50% or greater decrease in tumor size. The overall 1-year survival rate was 43% and 67% in patients who received 50 Gy or greater tumor dose. Lipiodol distribution pattern of the tumor indicated some difference in the prognosis between the scattered pattern and solid pattern. The solid pattern showed a statistically significant better survival rate. Patients treated with TAIR alone versus those treated with TAIR and chemotherapy showed no difference in their survival rate.

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References

  1. Sato M., Yamada R (1983) Experimental and clinical studies on the hepatic artery embolization for treatment of hepatoma. Nippon Acta Radiol 43:977–1005

    Google Scholar 

  2. Konno T., Maeda H, Iwai K., Maki S., Tashiro S., Uchida M., Miyauchi Y (1984) Selective targeting of anti-cancer drug and simultaneous imaging enhancement in solid tumors by arterially administrated lipid contrast medium. Cancer 54:2367–2374

    Article  PubMed  CAS  Google Scholar 

  3. Phillips R, Murikami K (1960) Primary neuplasms of the liver. Results of radiation therapy.Cancer 13:714–720

    Article  PubMed  CAS  Google Scholar 

  4. Kobayashi H, Nakajo M, Shimabukuro K, Shirono K, Sakata H, Oyama T, Sonoda T, Shinohara S (1984) Possibility of radiotherapy of hepatic cancer by transcatheter arterial embolization with radiactive Lipiodol. Nippon Acta Radiol 44:96–98

    PubMed  CAS  Google Scholar 

  5. Kobayashi H, Hidaka H, Kajiya Y, Tanoue P, Inoue H, Ikeda K Nakajo M, Shinohara S (1986) Treatment of hepatocellular carcinoma by transarterial injection of anticancer agents in iodized oil suspension of radioactive iodized oil solution. Acta Radiol 27:139–147.

    CAS  Google Scholar 

  6. Onohara S, Kobayashi H, Itoh Y, Shinohara S (1988) Intraarterial cis-platinum infusion with sodium thiosulfate protection and angiotensin II induced hypertension for treatment of hepatocellular carcinoma. Acta Radiol 29:197–202

    Article  PubMed  CAS  Google Scholar 

  7. WHO (1979) WHO handbook for reporting results of cancer treatment. WHO Offset Publication No. 48, Geneva, p 7

  8. Liver Cancer Study Group of Japan (1987) The general rules for the clinical and the pathological study of primary liver cancer, 2nd ed. pp 23–24

  9. Contreras MA, Bale WF, Spar IL (1983) Iodine monochloride (ICL) iodination techniques. Meth Enzymol 92: 277–292

    Article  PubMed  CAS  Google Scholar 

  10. Nakajo M, Kobayashi H, Shimabukuro K, Shirono K, Sakata H, Taguchi M, Uchiyama N, Sonoda T, Shinohara S (1988) Biodistribution and in vivo kinetics, of iodine-131 Lipiodol infused via the hepatic artery of patients with hepatic cancer. J Nucl Med 29:1066–1077

    PubMed  CAS  Google Scholar 

  11. Kajiya Y, Kobayashi H, Hidaka H, Onohara S, Maeda T, Ikeda K, Inoue H, Oyama T, Sonoda T, Shinohara S (1984) MMC-oil suspension (MOS) as a new chemoembolic agent. Nippon Acta Radiol 25:624–627

    Google Scholar 

  12. Shyder WS, Ford MR, Warner GC (1975) “S” absorbed dose per unit cumulated activity for selected radionuclides and organs MIRD Pamphlet No. 11, Society of Nuclear Medicine, New York

    Google Scholar 

  13. Macey DJ, Marshall R (1982) Absolute quantitation of radiotracer uptake in the lungs using a gamma camera. J Nucl Med 23:731–735

    PubMed  CAS  Google Scholar 

  14. Japan Society for Cancer Therapy (1986) Assessment of response to chemotherapy in solid tumor. Soc Cancer Ther 21:929–942

    Google Scholar 

  15. Kaplan El, Meier P (1958) Nonparametric estimation for incomplete observation. J Am State Assoc 53:457–481

    Article  Google Scholar 

  16. Ingold JA, Reed GB, Kaplan HS, Bagshow MA (1965) Radiation hepatitis. AJR 93:200–208

    CAS  Google Scholar 

  17. El-Domeiri AA, Huvos AG, Goldsmith HS, Foote FW (1971) Primary malignant tumors of the Liver. Cancer 27:7–11

    Article  PubMed  CAS  Google Scholar 

  18. Mantravadi RVP, Spigos DG, Tan WS, Felix EL (1982) Internal yttrium 90 in the treatment of hepatic malignancy. Radiology 142:783–786

    PubMed  CAS  Google Scholar 

  19. Grady ED (1984) Adjuvant therapy of Dukes' C colon cancer by intra-arterial P-32 colloid for internal radiation therapy of the Liver. Am Surg 50:488–492

    PubMed  CAS  Google Scholar 

  20. Order SE, Stillwagen GB, Klein JL, Leicher PK, Sigelman SS, Fishman EK, Ettinger DS, Haulk T, Kopher K., Finney K, Surdyke M, Self S, Leibel S (1985) iodine 131 antiferritin, a new treatment modality in hepatoma: A radiation therapy oncology group study. J Clin Oncol 3: 1573–1582

    PubMed  CAS  Google Scholar 

  21. Nakakuma K., Tashiro S, Uemura K, Imano T, Tanaka M Yokoyama I (1979) Studies on anti-cancer treatment with an oily anti-cancer drug injected into the ligated hepatic artery for liver cancer (preliminary report). Nichidoku Iho 24:675–682

    Google Scholar 

  22. Kobayashi H, Nakajo M, Yano T, Shimabukuro K, Shinohara S (1985) Transcatheter internal radiation of hepatoma using radioactive iodized oil (I-131 Lipiodol). Nippon Acta Radiol 45:1176–1178

    PubMed  CAS  Google Scholar 

  23. Madsen MT, Park CH, Thakur ML (1988) Dosimetry of iodine 131 etiodol in the treatment of hepatoma. J Nucl Med 29:1038–1044

    PubMed  CAS  Google Scholar 

  24. Yoo HS, Park CH, Suh JH, Lee JT, Kim BS, Madsen MT (1989) Radioiodinated fatty acid esters in the management of hepatocellular carcinoma: Preliminary findings Cancer Chemother Pharmacol 23:54–58

    Article  Google Scholar 

  25. Bretagne JF, Raul JL, Bourget P, Duvauferrier R, Deugnier Y, Faroux R, Ramee A, Herry JY, Gastard J (1988) Hepatic artery injection of I-131 labeled Lipiodol. Part 2. Preliminary results of therapeutic use in patients with hepatocellular carcinoma and liver metastasis. Radiology 168:547–550

    PubMed  CAS  Google Scholar 

  26. Hisada K, Furudate M, Sasaki Y (1968) A new textbook of clinical nuclear medicine. 1st ed. Kanehara Shuppan Ltd. pp 168–180.

  27. Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura H, Nakamura K, Takashima S (1983) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 148:397–401

    PubMed  CAS  Google Scholar 

  28. Takayasu K. Suzuki M., Uesaka K, Muramatsu Y, Moriyama N, Yoshida T, Yoshio M., Okazaki N, Hasegawa H (1989) Hepatic artery embolization for inoperable hepatocellular carcinoma: Prognosis and risk factor. Cancer Chemother Pharmacol 23:123–125

    Article  Google Scholar 

  29. Makuuchi M, Sugihara M, Mori T, Kobayashi J, Yamasaki S, Hasagawa H, Moriyama N, Takayasu K, Hirahashi S (1985) Bile duct necrosis: complication of transcatheter hepatic artery embolization. Radiology 156:331–334

    PubMed  CAS  Google Scholar 

  30. Takayasu K, Moriyama N, Muramatsu Y, Shima Y, Ushio K, Yamada T, Kishi K, Hasegawa H (1985) Gallbladder infarction after hepatic artery embolization, AJR 144:135–138

    PubMed  CAS  Google Scholar 

  31. Nakao N, Miura K, Takayasu Y, Wada T, Takahashi H Hayashi T, Miura T (1984) Indication of transcatheter arterial embolization: Hepatocellular carcinoma with liver cirrhosis evaluated from the liver function tests. Jpn Gastroenterol 81:1995–1999

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-shi, 890, Kagoshima, Japan

    Yoshiki Kajiya, Hisashi Kobayashi & Masayuki Nakajo

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  1. Yoshiki Kajiya
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  2. Hisashi Kobayashi
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  3. Masayuki Nakajo
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Kajiya, Y., Kobayashi, H. & Nakajo, M. Transarterial internal radiation therapy with I-131 lipiodol for multifoca hepatocellular carcinoma: Immediate and long-term results. Cardiovasc Intervent Radiol 16, 150–157 (1993). https://doi.org/10.1007/BF02641884

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