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Speculations on the nature of the metabolic defects in Tay-Sachs, Niemann-Pick, Gaucher’s and Alzheimer’s diseases, and metachromatic leucodystrophy

  • Technical
  • 15th Annual Summer Program Symposium On Quantitative Methodology In Lipid Research. Part II
  • Published:
Journal of the American Oil Chemists Society

Abstract

It is concluded that the defect in Tay-Sachs disease is for an enzyme degrading a monosialoganglioside, in Niemann-Pick disease for an enzyme degrading sphingomyelin or possibly ceramide, in chronic Gaucher’s disease for an enzyme degrading a glucocerebroside, and in metachromatic leucodystrophy for an enzyme for degradation of sulfatide. Alzheimer’s disease does not appear to involve any specific changes in lipid composition. An hypothesis to explain the findings in Alzheimer’s disease is presented.

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Authors and Affiliations

  1. Department of Biochemistry, City of Hope Medical Center, Duarte, California

    George Rouser, Gene Kritchevsky & Claudio Galli

Authors
  1. George Rouser
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  2. Gene Kritchevsky
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  3. Claudio Galli
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Rouser, G., Kritchevsky, G. & Galli, C. Speculations on the nature of the metabolic defects in Tay-Sachs, Niemann-Pick, Gaucher’s and Alzheimer’s diseases, and metachromatic leucodystrophy. J Am Oil Chem Soc 42, 412–416 (1965). https://doi.org/10.1007/BF02635578

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  • DOI: https://doi.org/10.1007/BF02635578

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