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Unsaturated lipid peroxidation catalyzed by hematin compounds and its inhibition by vitamin E1

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Journal of the American Oil Chemists Society

Abstract

Evidence favoring hematin catalysis over autoxidation as the dominant mechanism of lipid peroxidation in animal tissues is presented. Lipid peroxidation in Erlich ascites tumor cells and isolated electron transport particles has been studied. Random destruction of the cytochromes and a loss of catalytic activity correlate with peroxidation of the electron transport particle.

Mixtures of α-, β-, and γ-tocopherols show no synergistic effect. Synergism with ascorbate and citrate greatly enhance the antioxidant activity of α-tocopherol. A tocopherol-ascorbate-glutathione-triphosphopyridine nucleotide couple could act synergistically to inhibit lipid peroxidation in animal tissues.

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Author notes

  1. W. Duane Brown

    Present address: Institute of Marine Resources, University of California, Berkeley

  2. V. P. Maier

    Present address: U.S.D.A. Fruit and Vegetable Laboratory, Passdena, Calif

Authors and Affiliations

  1. Department of Food Science and Technology, University of California, Davis, California

    A. L. Tappel, W. Duane Brown, H. Zalkin & V. P. Maier

Authors
  1. A. L. Tappel
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  2. W. Duane Brown
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  3. H. Zalkin
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  4. V. P. Maier
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Additional information

Supported in part by the Bureau of Commercial Fisheries.

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Tappel, A.L., Brown, W.D., Zalkin, H. et al. Unsaturated lipid peroxidation catalyzed by hematin compounds and its inhibition by vitamin E1 . J Am Oil Chem Soc 38, 5–9 (1961). https://doi.org/10.1007/BF02633109

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  • DOI: https://doi.org/10.1007/BF02633109

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