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Metabolism ofortho-alkylbenzenealkanoic acid in rats

  • Technical
  • Published:
Journal of the American Oil Chemists Society

Abstract

Aromatic fatty acids with 18 C-atoms, as isolated from cyclized linseed oil, were labeled with3H in the aromatic ring by isotopic exchange. Doses of 50 mg/kg body weight were almost quantitatively absorbed by rats and excretion of metabolites via the urine was rapid (up to 95% within 30 hr). The retention curve consisted of two branches, which indicates that part of the aromatic acids are taken up into the lipid pool. This was confirmed by analysis of body lipids. The metabolic pathways involved in the degradation of the aromatic fatty acids are β-oxidation, ω-oxidation and (ω-1)-oxidation.

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Authors and Affiliations

  1. Unilever Research Laboratory, Vlaardingen, The Netherlands

    H. Van Tilborg, J. De Bruijn, J. J. Gottenbos & G. K. Koch

Authors
  1. H. Van Tilborg
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  2. J. De Bruijn
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  3. J. J. Gottenbos
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  4. G. K. Koch
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Additional information

Presented in part at the Ninth ISF-Congress, Rotterdam, September 1968.

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Van Tilborg, H., De Bruijn, J., Gottenbos, J.J. et al. Metabolism ofortho-alkylbenzenealkanoic acid in rats. J Am Oil Chem Soc 47, 430–437 (1970). https://doi.org/10.1007/BF02632960

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  • DOI: https://doi.org/10.1007/BF02632960

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