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6-Hydroxychroman-2-carboxylic acids: Novel antioxidants

  • Technical
  • Published:
Journal of the American Oil Chemists Society

Abstract

6-Hydroxychroman-2-carboxylic acids (I) have been found to be effective antioxidants in animal fats, vegetable oils, and emulsion systems. Two new

syntheses of these compounds have been developed. Structure-activity correlations for I with various substitutents at C2, C5, C7, and C8 in various test systems have been obtained. In addition, the homologous chroman acetic acids, which are also antioxidants, and a number of other derived compounds have been synthesized. The most effective antioxidant in this series is the tetramethyl compound I (R2=R5=R7=R8=CH3). This compound has activity which compares well with the better commercial antioxidants.

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Author information

Authors and Affiliations

  1. Chemical Research Department, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey

    John W. Scott

  2. Food and Agricultural Products Division, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey

    Winifred M. Cort & Hampton Harley

  3. Chemical Research Department, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey

    David R. Parrish & Gabriel Saucy

Authors
  1. John W. Scott
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  2. Winifred M. Cort
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  3. Hampton Harley
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  4. David R. Parrish
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  5. Gabriel Saucy
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Scott, J.W., Cort, W.M., Harley, H. et al. 6-Hydroxychroman-2-carboxylic acids: Novel antioxidants. J Am Oil Chem Soc 51, 200–203 (1974). https://doi.org/10.1007/BF02632894

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  • DOI: https://doi.org/10.1007/BF02632894

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