Summary
Sixteen insulin-dependent diabetic children and adolescents were studied on intenisifed insulin treatment (3II) and during continuous subcutaneous insulin infusion (CSII). Mean blood glucose, M-value and 24-h glycosuria were similar in both types of treatment. Symptomatic hypoglycemia occurred more often in patients on 3II than CSII. With 3II we observed blood glucose peaks early in the morning confirming that better overnight control can be achieved by CSII.
References
Bojsen J., Deckert T., Kørlendorf K., Lørup B.: Patient-controlled portable insulin infusion pump in diabetics — Diabetes28, 974, 1979.
Kølendorf K., Bojsen J., Lørup B.: Improvement of glucose homeostasis in insulin-dependent diabetics using a miniature insulin infusion pump with a fixed profile — Diabetologia18, 141, 1980.
Nelson J. D., Albisser A. M., Marliss E. B., Zinman B.: Role of continuous component in subcutaneous ‘open-loop’ insulin delivery — Lanceti, 1383, 1980.
Pickup J. C., Keen H., Parsons J. A., Alberti K. G. M. M.: Continuous subcutaneous insulin infusion: an approach to achieve normoglycaemia — Brit. Med. J.i, 204, 1978.
Pickup J. C., Keen H., Parsons J. A., Alberti K. G. M. M.: Continuous subcutaneous insulin infusion: good blood glucose control for up to 4 days — Diabetologia16, 385, 1979.
Pickup J. C., Keen H., Parsons J. A., Alberti K. G. M. M., Rowe A. S.: Continuous subcutaneous insulin infusion: improved blood-glucose and intermediary metabolite control in diabetics — Lanceti, 1255, 1979.
Pickup J. C., Keen H., Parsons J. A., White M., Alberti K. G. M. M.: Long-term continuous subcutaneous insulin infusion in diabetics at home — Lanceti, 870, 1979.
Rizza R., Gerich J., Haymond M., Westland K., Hall L., Clemens A., Service J.: Control of blood sugar in insulin dependent diabetics: comparison of an endocrine pancreas, continuous subcutaneous insulin infusion and intensified conventional insulin therapy — New Engl. J. Med.303, 1313, 1980.
Schlichtkrull J., Munck O., Jersild M.: The M-value, an index of blood sugar control in diabetics — Acta med. scand.177, 95, 1965.
Service J., George M., Rosevear J., Ackerman E., Gatewood L., Taylor W.: Mean amplitude of glucose excursions, a measure of diabetic instability — Diabetes19, 644, 1970.
Tamborlane W. V., Sherwin R. S., Genel M., Felig P.: Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump — New Engl. J. Med.300, 573, 1979.
Tamborlane W. V., Sherwin R. S., Genel M., Felig P.: Restoration of normal lipid and amino acid metabolism in diabetic patients treated with a portable insulin-infusion pump — Lanceti, 1258, 1979.
Tamborlane W. V., Sherwin R. S., Genel M., Felig P.: Outpatient treatment of juvenileonset diabetes with a preprogrammed portable subcutaneous insulin infusion system — Amer. J. Med.68, 190, 1980.
Viberti G. C., Pickup J., Phil D., Jarrett R. J., Keen H.: Effect of control of blood glucose on urinary excretion of albumin and beta microglobulin in insulin-dependent diabetes — New Engl. J. Med.303, 638, 1979.
Author information
Authors and Affiliations
Additional information
Supported byConsiglio Nazionale delle Ricerche, Grant No. 80.00410.
Rights and permissions
About this article
Cite this article
Meschi, F., Beccaria, L., Vanini, R. et al. Short-term subcutaneous insulin infusion in diabetic children. Comparison with three daily insulin injections. Acta diabet. lat 19, 371–375 (1982). https://doi.org/10.1007/BF02629260
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02629260