Summary
Seven continuous primate cell lines were tested in three systems (nude mice, muscle organ culture, and soft agarose) for their ability to express characteristics usually associated with malignant cell lines. Five of the seven cell lines failed to produce tumors in nude mice, failed to show a tumor-like pattern of growth in muscle organ culture, and failed to produce colonies in soft agarose. The remaining two cell lines showed different degrees of tumorigenicity in nude mice, and gave frankly positive results in the twoin vitro assays. In addition, one of these lines appeared to progress from potential to overt tumorigenicity. We conclude that acquisition of infinite life in primate cell lines is not invariably equivalent to the ability to form tumors.
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Petricciani, J.C., Levenbook, I.S., Wierenga, D.E. et al. Early passage primate cell immortality is independent of tumorigenicity. In Vitro Cell Dev Biol 23, 523–526 (1987). https://doi.org/10.1007/BF02628424
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DOI: https://doi.org/10.1007/BF02628424