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Selective inhibitors of dihydrofolate reductase

  • Nobel Lectures in Physiology or Medicine—1988
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References

  1. C. H. Fiske and Y. Subbarow,Science,70, 381 (1929).

    Article  CAS  PubMed  Google Scholar 

  2. G. H. Hitchings, Dissertation, Harvard University (1933).

  3. D. D. Woods,Brit. J. Exptl. Path.,21, 74 (1940).

    CAS  Google Scholar 

  4. P. Fildes,Lancet I, 955 (1940).

    Article  CAS  Google Scholar 

  5. G. H. Hitchings, E. A. Falco and M. B. Sherwood,Science,102, 251 (1945).

    Article  CAS  PubMed  Google Scholar 

  6. E. A. Falco, G. H. Hitchings, P. B. Russell and H. Vander Werff,Nature,164, 107 (1949).

    CAS  PubMed  Google Scholar 

  7. G. H. Hitchings, G. B. Elion, H. Vander Werff and E. A. Falco,J. Biol. Chem.,174, 765 (1948).

    CAS  PubMed  Google Scholar 

  8. J. H. Burchenal, D. A. Karnofsky, E. M. Kingsley-Pillers, C. M. Southam, W. P. Laird Meyers, G. C. Escher, L. F. Craver, H. W. Dargeon and C. P. Rhoads,Cancer,4, 549 (1951).

    Article  PubMed  CAS  Google Scholar 

  9. G. H. Hitchings,Drug Intell. Clin. Pharn.,16, 843 (1982).

    CAS  Google Scholar 

  10. G. H. Hitchings and J. J. Burchall,Adv. Enzymol.,27, 417 (1965).

    PubMed  CAS  Google Scholar 

  11. G. H. Hitchings and S. L. Smith,Adv. Enzyme Reg.,18, 349 (1980).

    Article  CAS  Google Scholar 

  12. G. H. Hitchings and B. Roth, inEnzyme Inhibitors as Drugs, Ed. by M. Sandler, Baltimore University Park Press, pp. 263–280 (1980).

    Google Scholar 

  13. G. H. Hitchings, E. A. Falco, G. B. Elion, S. Singer, G. B. Waring, D. J. Hutchinson and J. H. BurchenalArch. Biochem. Biophys.,40, 479 (1952).

    Article  PubMed  CAS  Google Scholar 

  14. G. H. Hitchings, inDrugs, Parasites and Hosts, Ed. by L. G. Goodwin and R. H. Nimmo-Smith Boston, Little-Brown, pp. 196–210 (1962).

    Google Scholar 

  15. A. C. Y. Chang, J. H. Nunberg, R. J. Kaufman, H. A. Erlich, R. T. Schimke and S. N. Cohen,Nature,275, 617 (1978).

    Article  PubMed  CAS  Google Scholar 

  16. S. RichardsonAdv. Protein Chem. 34, 167 (1981).

    Article  PubMed  CAS  Google Scholar 

  17. D. A. Matthews, S. L. Smith, D. P. Baccanari, J. J. Burchall, S. J. Oatley and J. Kraut,Biochemistry 25, 4194 (1986).

    Article  PubMed  CAS  Google Scholar 

  18. J. Burchall, Wellcome Scientist Lecture (1983).

  19. S. R. M. Bushby, inTrimethoprim-sulfamethoxazole, Microbiological, Pharmacological and Clinical Considerations, Ed. by M. Finland and E. H. Kass, pp. 10–30 (1973).

  20. G. B. Elion, S. Singer and G. H. Hitchings,Antibiot. Chemother.,10, 556 (1960).

    CAS  Google Scholar 

  21. S. Farber et alN. Engl. J. Med.,238, 787 (1948).

    Article  CAS  PubMed  Google Scholar 

  22. B. Roth, E. Bliss, and C. R. Beddell, inMolecular Aspects of Anti-Cancer Drug Action, Ed. by S. Neidle and M. J. Waring, London, Macmillan, pp. 363–393 (1983).

    Google Scholar 

  23. D. A. Matthews, J. T. Bolin, J. M. Burridge, D. J. Filman, K. W. Volz, B. T. Kaufman, C. R. Beddell, J. N. Champness, D. K. Stammers and J. Kraut,J. Biol. Chem.,260, 381 (1985).

    PubMed  CAS  Google Scholar 

  24. J. E. Villafranca, E. H. Howell, D. H. Voet, M. S. Strobel, R. C. Ogden, J. N. Abelson and J. Kraut,Science,222, 782 (1983).

    Article  PubMed  CAS  Google Scholar 

  25. J. J. McGuire and J. K. Coward, inFolates and Pterins, Vol 1, Ed. by R. L. Blakley and S. J. Benkovic, New York, Wiley, pp. 135–190 (1984).

    Google Scholar 

  26. C. J. Allegra, J. C. Drake, J. Jolivet and B. A. Chabner, inProceedings of the Second Workshop on Folyl and Antifolyl Polyglutamates, Ed. by I. D. Goldman, New York, Praeger, pp. 348–359 (1985).

    Google Scholar 

  27. C. R. Beddell, inX-ray Crystallography and Drug Action, Ed. by A. S. Horn and C. J. DeRanter, Oxford, Oxford Univ. Press, 169–193 (1984).

    Google Scholar 

  28. L. F. Kuyper, B. Roth, D. P. Baccanari, R. Ferone, C. R. Beddell, J. N. Champness, D. K. Stammers, J. G. Dann, F. E. Norrington and D. J. Baker,J. Med. Chem.,28, 303 (1985).

    Article  PubMed  CAS  Google Scholar 

  29. J. H. Chan, L. F. Kuyper and B. Roth,189th Am. Chem. Soc. Meeting Abstracts, MEDI 87 (1985).

  30. J. T. Lin and J. R. Bertino,J. Clin. Oncol.,5, 2032 (1987).

    PubMed  CAS  Google Scholar 

  31. C. J. Allegra, B. A. Chabner, C. U. Tuazon, D. Ogata-Arakaki, B. Baird, J. C. Drake, J. T. Simmons, E. E. Lack, J. H. Shelhamer, F. Balis, R. Walker, J. A. Kovacs, H. C. Lane and H. Masur,N. Engl. J. Med.,317, 978 (1987).

    Article  PubMed  CAS  Google Scholar 

  32. F. Aruajo, D. R. Guptill and J. S. Remington,J. Infect. Dis.,156, 828 (1987).

    Google Scholar 

  33. D. J. Fernandes, J. R. Bertino and J. B. Hynes,Cancer Res.,43, 1117 (1983).

    PubMed  CAS  Google Scholar 

  34. G. H. Hitchings, inDiscoveries, Ed. by A. Burgen, Cambridge, Cambridge University Press, in press.

  35. G. H. Hitchings,Cancer Res.,29, 1895 (1969).

    PubMed  CAS  Google Scholar 

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The Nobel Foundation 1989.

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Hitchings, G.H. Selective inhibitors of dihydrofolate reductase. In Vitro Cell Dev Biol 25, 303–310 (1989). https://doi.org/10.1007/BF02624591

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