Summary
Two cases of chronic ulcerative colitis occurring in brothers who ultimately developed cancer of the large bowel are presented. These are the first cases of this kind that the authors have been able to discover in medical literature. The possibility of hereditary predisposition to both ulcerative colitis and cancer is discussed.
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References
Bacon, H. E.: Ulcerative Colitis. Philadelphia, J. B. Lippincott Company, 1958, 395 pp.
Banks, B. M., B. I. Korelitz and L. Zetzel: The course of nonspecific ulcerative colitis: Review of twenty years’ experience and late results. Gastroenterology.32: 983, 1957.
Bicks, R. O., J. B. Kirsner and W. L. Palmer: Serum proteins in ulcerative colitis. I. Electrophoretic patterns in active disease. Gastroenterology.37: 256, 1959.
Brown, C. H., J. R. Haserick and E. K. Shirey: Chronic ulcerative colitis with systemic lupus erythematosus. Cleveland Clin. Quart.23: 43, 1956.
Cattell, R. B. and E. J. Boehme: The importance of malignant degeneration as a complication of chronic ulcerative colitis. Gastroenterology.8: 695, 1947.
Counsell, P. B. and C. E. Dukes: The association of chronic ulcerative colitis and carcinoma of the rectum and colon. Brit. J. Surg.39: 485, 1952.
Doll, R. and T. D. Kellock: The separate inheritance of gastric and duodenal ulcers. Ann. Eugenics.16: 231, 1951.
Gardner, E. J.: The Principles of Genetics. New York, John Wiley & Sons, Inc., 1960, pp. 107, 307.
Graham, S. and A. M. Lilienfeld: Genetic studies of gastric cancer in humans: An appraisal. Cancer.11: 945, 1958.
Houghton, E. A. W. and J. M. Naish: Familial ulcerative colitis and ileitis. Gastroenterologia.89: 65, 1958.
Jackman, R. J., J. A. Bargen and H. F. Helmholz: Life histories of ninety-five children with chronic ulcerative colitis: A statistical study based on comparison with a whole group of eight hundred and seventy-one patients. Am. J. Dis. Child.59: 459, 1940.
Karnofsky, D. A.: Principles of neoplasia. In: Principles of Internal Medicine. Ed. 3, New York, McGraw-Hill Book Company, Inc., 1958, p. 421.
Kelley, M. L., Jr. and V. W. Logan: Erythema nodosum in association with chronic ulcerative colitis. Gastroenterology.31: 285, 1956.
Kirsner, J. B. and M. B. Goldgraber: Hypersensitivity, auto-immunity, and the digestive tract. Gastroenterology.38: 536, 1960.
Lagercrantz, R.: Follow-up investigation of children with ulcerative colitis: With special reference to indications for surgical therapy. Acta paediat.44: 302, 1955.
Lyons, A. S. and J. H. Garlock: The relationship of chronic ulcerative colitis to carcinoma. Gastroenterology.18: 170, 1951.
Lyons, C. K. and R. W. Postlethwait: Chronic ulcerative colitis in twins: Case report. Gastroenterology.10: 545, 1948.
McConnell, R. B.: Heredity in gastroenterology: A review. Gut.1: 273, 1960.
Ransom, H. K.: Quoted by Sandweiss, D. J. and M. H. Sugarman (Ref. 20).
Sandweiss, D. J. and M. H. Sugarman: What is new in the treatment of ulcerative colitis? J. Michigan M. Soc.55: 1461, 1956.
Sloan, W. P., Jr., J. A. Bargen and R. P. Gage: Life histories of patients with chronic ulcerative colitis: A review of 2,000 cases. Gastroenterology.16: 25, 1950.
Spriggs, E. I.: Chronic ulceration of the colon. Quart. J. Med.3: 549, 1934.
Svartz, N. and T. Ernberg: Cancer coli in cases of colitis ulcerosa. Acta med. scandinav.135: 444, 1949.
Webb, L. R., Jr.: The occurrence of chronic ulcerative colitis in twin males. Gastroenterology.15: 523, 1950.
Wheelock, F. C., Jr. and R. E. Warren: Ulcerative colitis: Follow-up studies. New England J. Med.252: 421, 1955.
Woolf, C. M.: A genetic study of carcinoma of the large intestine. Am. J. Human Genet.10: 42, 1958.
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Gazzaniga, A.B., Gazzaniga, D.A. Carcinoma of the colon following chronic ulcerative colitis. Dis Colon Rectum 5, 437–443 (1962). https://doi.org/10.1007/BF02616647
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DOI: https://doi.org/10.1007/BF02616647