Abstract
Standard cytotoxic regimens have failed to prolong survival in patients with recurrent cervical cancer; therefore, new agents or combinations of agents are necessary to improve outcome. Cisplatin and 5-fluorouracil are one of the most active regimens currently available for recurrent cervical cancer. Interferon-α can potentiate thein vitro andin vivo activity of both agents. Therefore, we sought to define the feasibility and activity of adding interferon-α to the cisplatin-5-fluorouracil regimen. Patients with histologically proven recurrent cervical carcinoma received interferon-α (5×106 units/m2/day for 5 days) combined with cisplatin (75 mg/m2 on day 1) plus 5-fluorouracil (500 mg/m2/day for 5 days) in recurrent cervical cancer. Twenty-six patients were included in this study and received a total of 95 courses of therapy. All 26 had prior radiotherapy and five had prior chemotherapy. This regimen was relatively well tolerated as toxicity was comparable to that of cisplatin plus 5-fluorouracil alone. Major response occurred in 8 patients (31%) and 5 (19%) had complete responses. The median response duration was 6 months (range, 2–34 months) and the median survival duration was 9 months (range, 2–38 months).
The addition of interferon-α to cisplatin plus 5-fluorouracil is feasible. Further studies will be necessary to determine if the addition of interferon-α to this regimen is superior to cisplatin plus 5-fluorouracil alone.
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Gonzales-de Léon, C., Lippman, S.M., Kudelka, A.P. et al. Phase II study of cisplatin, 5-fluorouracil and interferon-α in recurrent carcinoma of the cervix. Invest New Drugs 13, 73–76 (1995). https://doi.org/10.1007/BF02614224
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DOI: https://doi.org/10.1007/BF02614224