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Subfamily structure and evolution of the human L1 family of repetive sequences

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Summary

Comparative analysis of the available 3′-portions of the human L1 (LINE-1) family of repeated sequences indicates that all the sequences can be classified in two major subfamilies. The division is based on patterns of diagnostic bases shared within L1 subfamilies of sequences but differing between them. The overall ratio of replacement to synonymous positions, occupied by the diagnostic bases in the large open reading frame of the L1 sequence, is 1.15. This indicates that both subfamilies were obtained from genes coding for functional proteins. The L1 subfamilies appear to be of different ages and may represent a “fossil record” of the same active gene at different times in the history of primates. The younger subfamily can be split further into at least two closely related branches of sequences. The above facts combined with the recent data for the Alu subfamily structure show that LINE and SINE families of interspersed repeats share discontinuous patterns in their evolution. These data are consistent with the model that both Alu and L1 families, as well as other pseudogene families, contain active genes producing discrete layers of pseudogenes throughout the history of primates. Models of evolutionary processes that could generate these discontinuities are discussed together with the possible biological role of Alu and L1 genes.

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  1. Linus Pauling Institute of Science and Medicine, 440 Page Mill Road, 94306, Palo Alto, California, USA

    Jerzy Jurka

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  1. Jerzy Jurka
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Jurka, J. Subfamily structure and evolution of the human L1 family of repetive sequences. J Mol Evol 29, 496–503 (1989). https://doi.org/10.1007/BF02602921

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  • DOI: https://doi.org/10.1007/BF02602921

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