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Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells

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International Journal of Clinical and Laboratory Research

Summary

Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that non-hematopoietic cells, including endothelial cells, respond to these cytokines. In this review we describe their effects on endothelial cells, underlining their role in the behavior and survival of the microenvironment of bone marrow, in the angiogenesis process related to the progression of solid tumors and of vascular tumors, and in the homing of lymphocytes.

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Authors and Affiliations

  1. Dipartimento di Genetica, Biologia e Chimica Medica, Via Santena 5 bis, I-10126, Turin, Italy

    Federico Bussolino, Elena Bocchietto & Antonella Guglielmetti

  2. Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy

    Francesco Colotta & Alberto Mantovani

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  1. Federico Bussolino
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  2. Francesco Colotta
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  3. Elena Bocchietto
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  4. Antonella Guglielmetti
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  5. Alberto Mantovani
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Bussolino, F., Colotta, F., Bocchietto, E. et al. Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells. Int J Clin Lab Res 23, 8–12 (1993). https://doi.org/10.1007/BF02592273

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