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Creatine kinase reaction rates in rat brain during chronic ischemia

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Abstract

Creatine kinase reaction rates were measured by magnetisation transfer technique in the brain of healthy adult and aged rats and in the rats with mild or severe chronic cerebral ischemia. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the case of chronic brain ischemia in aged rats. In contrast, occlusion of both carotid arteries in adult rats produced a slight increase in the reaction rate 4 weeks after occlusion. At the same time, corresponding conventional phosphorus magnetic resonance spectra showed negligible changes in signal intensities.

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Authors and Affiliations

  1. Department of Radiology, Dérer Faculty Hospital, Limbová 5, 833 05, Bratislava, Slovak Republic

    V. Mlynárik & V. Belan

  2. NMR Laboratory, Slovak Technical University, Bratislava, Slovak Republic

    S. Kašparová & T. Liptaj

  3. Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic

    D. Dobrota

  4. Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic

    J. Horecký

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  1. V. Mlynárik
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  2. S. Kašparová
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  3. T. Liptaj
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  4. D. Dobrota
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  5. J. Horecký
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  6. V. Belan
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Correspondence to V. Mlynárik.

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Mlynárik, V., Kašparová, S., Liptaj, T. et al. Creatine kinase reaction rates in rat brain during chronic ischemia. MAGMA 7, 162–165 (1998). https://doi.org/10.1007/BF02591333

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  • DOI: https://doi.org/10.1007/BF02591333

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