Riassunto
1) Nei soggetti normali, la somministrazione orale di caffè normale e di caffeina determina aumento dei livelli plasmatici dei NEFA, senza modificare la glicemia, l’insulinemia, la cortisolemia e la somatotropinemia; 2) questo effetto mobilizzante i NEFA, esercitato dal caffè normale e dalla caffeina, non si osserva nei soggetti obesi; 3) nei soggetti normali, la somministrazione di caffeina migliora la tolleranza glicidica e potenzia l’effetto insulinogeno del glucosio p.o.
Résumé
1) Chez les sujets normaux, l’administration orale de café ordinaire ou de caféine entrîne un accroissement du taux des acides gras libres plasmatiques sans modifications de la glycémie, de l’insulinémie, de la cortisolémie et du taux plasmatique de l’hormone de croissance; 2) l’effet lipolytique de la caféine et du café ne s’observe pas chez les sujets obèses; 3) chez les sujets normaux, l’administration de caféine ameliore la tolérance glucidique et potentialise l’effet insulinogénique du glucose administré par voie orale.
Resumen
1) En individuos normales el suministro oral de café normal y de cafeína detérmina un aumento de los NEFA sin modificar la glucemia, la insulinemia, la cortisolemia y la somatotropinemia; 2) en los individuos obesos no se observa el efecto movilizador de los NEFA, ejercido por el café normal y por la cafeína; 3) en los individuos normales el suministro de cafeína mejora la tolerancia glucídica y potencia el efecto insulinógeno de la glucosa p.o.
Zusammenfassung
1) Bei Normalpersonen verursacht die Verabreichung von gewöhnlichem Kaffee oder von Koffein eine Steigerung der NEFA-Konzentration im Plasma ohne Blutzucker-, Plasmainsulin-, Kortisol- oder Wachstumshormonspiegel zu beeinflussen; 2) die lipolytische Wirkung des Koffeins und des Kaffees wird bei Adipösen nicht beobachtet; 3) bei Normalpersonen verbessert die Verabreichung von Koffein die Glukosetoleranz und potenziert den insulinogenen Effekt oral verabreichter Glukose.
Summary
1) In normal subjects, oral administration of regular coffee and of caffeine increases NEFA plasma concentration without modifying blood glucose, plasma insulin, cortisol and growth hormone concentration; 2) this NEFA mobilizing effect of caffeine and regular coffee is not observed in obese people; 3) in normal subjects, caffeine administration improves oral glucose tolerance and potentiates the insulinogenic effect of orally administered glucose.
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Chargé de Recherches du Fonds National de la Recherche Scientifique.
Traduzione a cura di G. U.
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Daubresse, JC., Luyckx, A., Demey-Ponsart, E. et al. Effects of coffee and caffeine on carbohydrate metabolism, free fatty acid, insulin, growth hormone and cortisol plasma levels in man. Acta diabet. lat 10, 1069–1084 (1973). https://doi.org/10.1007/BF02590703
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DOI: https://doi.org/10.1007/BF02590703